ID A0A0M9X635_9ACTN Unreviewed; 3457 AA.
AC A0A0M9X635;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 09-DEC-2015, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE SubName: Full=Polyketide synthase {ECO:0000313|EMBL:KOT31017.1};
GN ORFNames=ADK41_31505 {ECO:0000313|EMBL:KOT31017.1};
OS Streptomyces caelestis.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=36816 {ECO:0000313|EMBL:KOT31017.1, ECO:0000313|Proteomes:UP000037773};
RN [1] {ECO:0000313|EMBL:KOT31017.1, ECO:0000313|Proteomes:UP000037773}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NRRL B-24567 {ECO:0000313|EMBL:KOT31017.1,
RC ECO:0000313|Proteomes:UP000037773};
RA Noorani M.;
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC Evidence={ECO:0000256|ARBA:ARBA00001957};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KOT31017.1}.
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DR EMBL; LGCN01000238; KOT31017.1; -; Genomic_DNA.
DR PATRIC; fig|36816.3.peg.6821; -.
DR OrthoDB; 9778690at2; -.
DR Proteomes; UP000037773; Unassembled WGS sequence.
DR GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR GO; GO:0033068; P:macrolide biosynthetic process; IEA:UniProt.
DR CDD; cd08952; KR_1_SDR_x; 1.
DR CDD; cd08956; KR_3_FAS_SDR_x; 1.
DR CDD; cd00833; PKS; 2.
DR Gene3D; 3.30.70.3290; -; 2.
DR Gene3D; 3.40.47.10; -; 2.
DR Gene3D; 6.10.140.1830; -; 1.
DR Gene3D; 1.10.1200.10; ACP-like; 2.
DR Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 2.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR Gene3D; 3.10.129.110; Polyketide synthase dehydratase; 1.
DR InterPro; IPR001227; Ac_transferase_dom_sf.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR014043; Acyl_transferase.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR018201; Ketoacyl_synth_AS.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR032821; PKS_assoc.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR041618; PKS_DE.
DR InterPro; IPR042104; PKS_dehydratase_sf.
DR InterPro; IPR020807; PKS_DH.
DR InterPro; IPR049551; PKS_DH_C.
DR InterPro; IPR049552; PKS_DH_N.
DR InterPro; IPR013968; PKS_KR.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR015083; Polyketide_synth_docking.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR43775:SF51; PHENOLPHTHIOCEROL_PHTHIOCEROL POLYKETIDE SYNTHASE SUBUNIT E; 1.
DR Pfam; PF00698; Acyl_transf_1; 2.
DR Pfam; PF08990; Docking; 1.
DR Pfam; PF16197; KAsynt_C_assoc; 2.
DR Pfam; PF00109; ketoacyl-synt; 2.
DR Pfam; PF02801; Ketoacyl-synt_C; 2.
DR Pfam; PF08659; KR; 2.
DR Pfam; PF18369; PKS_DE; 1.
DR Pfam; PF21089; PKS_DH_N; 1.
DR Pfam; PF00550; PP-binding; 2.
DR Pfam; PF14765; PS-DH; 1.
DR SMART; SM00827; PKS_AT; 2.
DR SMART; SM00826; PKS_DH; 1.
DR SMART; SM00822; PKS_KR; 2.
DR SMART; SM00825; PKS_KS; 2.
DR SMART; SM00823; PKS_PP; 2.
DR SMART; SM01294; PKS_PP_betabranch; 2.
DR SUPFAM; SSF47336; ACP-like; 2.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 2.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 4.
DR SUPFAM; SSF55048; Probable ACP-binding domain of malonyl-CoA ACP transacylase; 2.
DR SUPFAM; SSF53901; Thiolase-like; 2.
DR PROSITE; PS50075; CARRIER; 2.
DR PROSITE; PS00606; KS3_1; 2.
DR PROSITE; PS52004; KS3_2; 2.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 1.
PE 4: Predicted;
KW Acyltransferase {ECO:0000256|ARBA:ARBA00023315};
KW Antibiotic biosynthesis {ECO:0000256|ARBA:ARBA00023194};
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000037773};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 27..446
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 1532..1607
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 1625..2050
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 3299..3374
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT REGION 1018..1082
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2642..2671
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3417..3439
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1059..1073
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2644..2658
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3457 AA; 358093 MW; 58D43321F2046916 CRC64;
MRDYLNRVTI DLRDTRRRLR EAESRTREPI AVVSMSCRFP GGARTPEELW DLLAAGRDTV
TGVPGDRGWD TGRLTAGGVP CRGAFLDGAA DFDAEFFAVS PHEAIAMDPQ QRLLLQAAWE
AVERAGIDPA SLRATRTGVF AAAIDQGYAQ LGTGAPETVQ GFLMTGNSMS VMSGRVAYAL
GLEGPAVTVD TACSASLVAL HQAARALRAE ECSLALAGGV TVMARPAVFT EFSRQGAMAA
DGRCKPFSAT ADGTGWGEGV GMLLLERLSD ARRHGHPVLA VLRGSAVNQD GASNGLTAPN
GPSQQRVIQA ALADAGLTAA DVGAVEAHGT GTTLGDPIEA DALLATYGTD RRAGQPLWLG
SLKSNIGHTQ AAAGVAGVIK TVLALRHGLL PRSLHITEPT PHVDWGEGTV ALLTEARKWP
GTDGPRRAGV SSFGMSGTNA HVILEEAPEP EPLPRSAGTA PDVVPCVLSG RTAAALRDQA
VRLRARLAAD PAARPADIGY SLATTRTAFA HRAAVTAADR AELLTSLDAL VRDTESTAVA
VSGLAEPGPG RIAMVFPGQG AQWPGMGREL LDTAPEFARS MAACEEALSP FVDWSLRDVV
RRDPGAAAPD RVDVVQPALF ATMVSLAALW RSWGVEPDAV VGHSQGEIAA AVVAGALSLA
DGAKVVALRS RAIAAFAGAG GMISLAVPRD RAEEVITPWV GRVSVAAVNG PASVVVSGDA
AALAELTAQC AADGVRARTI PVDYASHSAH VESIEEELLT ALAGLTPAAS TIPVFSTVTG
EWLDTTAMDA AYWYRNLRRT VCFDTAVRAL AEQGHGVFLE VSPHPVLTGP VQDTAEAAGV
PDVVVTGTLR RDEGGLRRAL TSAAGLWARG VPVDWRKVYE DWDAHPVDLP TYPFQQRRHW
LAPVSPTPVE GDTDFWDLVD RGDVSEAATA LAVDAAPLRA VLPALGAWRR HRNAPDVSGA
WRYRVAWHPV PDPPAAALSG RWLVLVPEGQ QESEKVRDAV RDVVRALREH GADVVTAGVA
TADGTVPTAG RPRTAPEPRS AGTTTAGPGP GTAAGPASAS ASGPGSTAAP GPQPGASSAD
GAERTRVVAA VAAAAADGRP LAGVLSLLGL ADRPHPRHPG LPTGTVLTLA LVQALGDLGV
TAPLWCATRG AVSTGGADPL TAPAQAQVWG TGMVAALEHP QRWGGLVDLP DALGPRARER
LCAALGGPDG EDQLAVRPTG LLARRLVRAP RPARPARTWK PRGTVLLTGG TGTLGPHLAR
WLARGGATHL VLPGRRGEDV PAAAGLRAEL AASGATLAMP VCDLADRGQV ERLLTGLDAD
GTPVTAVVHA AAYIALAPLD TIPVAAYERV VAAKAAGAAH LDALLDRELD AFVLFSSIAG
VWGSGDHGAY AAANAHLDAL AQYRRGRGLS ATTVDWGIWR AEPPSGGTVP PADGTAADLF
NLEEHGLPRI DAERALGTLQ QVLDDDETLV TVADVDWEQF APVFTSSRPS PLLRTVPEAR
RALEGHGDGD APAASELRRR LTALRLSAEQ DRLLLDLVRG HAAAVLGHDR ADAVPPGKAF
QELGLASLTA VELRNRLNKA TGLRLPSTLV FDHPSAAALA THLKSRLLGE EETAAVADDR
PKAGGEPIAI VAMSCRLPGG VTSPEELWRL LADRGDAVTG FPDGRGWDLD ALYDPDPEHP
GTSTTRHGGF LHDAADFDAA FFGISPREAL AMDPQQRLLL EVSWEALERA GLDPEALRGS
RTGVFTGVNY SDYGAAVARS AEGEGHLLTG SAPSVVSGRV AYTLGLEGPA VTVDTACSSS
LVALHLAARA LRAGDCSLAL VGGVAVMATP GALISFSRQR GLAADGRCKA FADDADGMGM
AEGAGVLLVE RLSEARRAGH PVLAVLRGSA INQDGASNGL SAPNGPSQQR VIRAALADAG
LSGADVDVVE AHGTGTTLGD PIEAQALLAT YGQDRSGGRP LLIGSLKSNI GHTQAVSGVA
GVMKTVLALR HAVVPATLHA HRPTTHVDWT QGAVTLATDA TPWPDTDRSR RAGVSSFGLS
GTNAHVVLEE APAPDTPAPG RPELEPTPAG PVLPWCLSAR SADALRDQAG RLLQHLTRTP
PADAADIALS LAGRTAFAHR AVLVGAHDRL LPALEEWAAG GTPTADGVTD PDGRTVLMFP
GQGSQWTGMA RRLLDESPEF ADAMRACADA LAPHVDWSLL DVVRDGGLER VDVVQPVLFA
VMVSLARLWR AYGVVPAAVV GHSQGEIAAA VVAGALTLED GAKVVALRSR AIARLDGHGG
MVSLALPSRQ AAEQIAPWEG RLSVAAVNGP SAVVVSGDAD ALDELLETCE RGGVRARRVD
VDYASHSAHM EALEAELVTA LEDIEPTAAD IPLYSTVTDG WLDTATMDAR YWYANLRRTV
GFESAVRALA AAGHRTYIEV SPHPVLVPAV EETLEAAGAD AAAVLGTLRR DDGGMERVLL
SLGAAWTHGA PVDWSPLFAG TAARRVDLPT YAFQHRPYWA VPGPETGGDV TAVGLGRTGH
PLLGAAVELA DTGETLLSGR ISARTHPWLA DHAVSDVVLL PGAAFVDLAV RAGDEAGCPV
LEELTLQAPL LLPATGGVQL QVRVGAPDGT ARRTVDVHAR PDADPAAPWT AHASGVLAAV
TASEAAREED REAAEADPSA QRAGRPPAGA EPVDVEDLYE RFAAAGYGYG PAFQGLRAAW
RHGGDLYTEV RLDEDQHAAA TAFGIHPALL DAALQGLWLV PGRTGDAAPA PGTARLPFAW
TGVTLHASGA TALRVRLSPD TDGTVSLAAH DPSGRPVITV TGLAVRPVDA EALRAATAPV
ADDCLYRLVW TPLPTPAGEP VPPGRWAALG SGVPLPDTYP DLAVLAEALD HGAAAPDVLL
VPCPTADGDD AAAVRALVAA TLGLLQAWLA DDRLADTRLV LLTRGAVRTG VDDGPGDPAA
AAARGLLRSA QSEYPGRLVL VDLSDGDDDP LALLPGALHL DEPQLAVRDG KLFAARLTRV
PAPEGAGERP APLDPDGTVL VTGAGGVLGG LVARHLAARY GVRHLLLAGR RGADTPGAVT
LLTDLRDLGA EAEFAACDLA DPAAVTKLLA RVPAGHPLTG VVHAAGVLDD GVVTSLTPER
LDRVLRPKAD AALVLHEATR GLPLSAFVLF SSAAGVVGNA GQANYAAANA FLDALAERRA
AAGLPAQSLA WGLWEQRSEM TGTLDGAGLD RMTRGGVAAL SDAQGLALLD AALRLDDALL
VPLRLDTARL RAAAERGSVP PLLRGLVRGT RPVATRADTG RAASLREQLA SLGAEERRER
IEELVRARVA DVLGHTGPEA IDPEQAFKDL GFDSLTAVDL RNRLNAATGL RLPATLVFDH
PTPVAAAAYV TARLAPPAEP AAPASPDDDR ELRRRLAAVP VKRLREAGLL DAVLRLAEPG
GGGADNGSAD PTDDPDTIKE MDVDALVRMA LDGDGRV
//