ID A0A0M9YFE8_9ACTN Unreviewed; 441 AA.
AC A0A0M9YFE8;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 09-DEC-2015, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Precorrin-6Y methyltransferase {ECO:0000313|EMBL:KOU45098.1};
GN ORFNames=ADK55_22315 {ECO:0000313|EMBL:KOU45098.1};
OS Streptomyces sp. WM4235.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1415551 {ECO:0000313|EMBL:KOU45098.1, ECO:0000313|Proteomes:UP000037699};
RN [1] {ECO:0000313|EMBL:KOU45098.1, ECO:0000313|Proteomes:UP000037699}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=WM4235 {ECO:0000313|EMBL:KOU45098.1,
RC ECO:0000313|Proteomes:UP000037699};
RA Noorani M.;
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Cofactor biosynthesis; adenosylcobalamin biosynthesis.
CC {ECO:0000256|ARBA:ARBA00004953}.
CC -!- SIMILARITY: Belongs to the precorrin methyltransferase family.
CC {ECO:0000256|ARBA:ARBA00005879}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KOU45098.1}.
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DR EMBL; LGDE01000349; KOU45098.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0M9YFE8; -.
DR PATRIC; fig|1415551.3.peg.4858; -.
DR UniPathway; UPA00148; -.
DR Proteomes; UP000037699; Unassembled WGS sequence.
DR GO; GO:0008276; F:protein methyltransferase activity; IEA:InterPro.
DR GO; GO:0009236; P:cobalamin biosynthetic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR CDD; cd02440; AdoMet_MTases; 1.
DR CDD; cd11644; Precorrin-6Y-MT; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR000878; 4pyrrol_Mease.
DR InterPro; IPR035996; 4pyrrol_Methylase_sf.
DR InterPro; IPR014777; 4pyrrole_Mease_sub1.
DR InterPro; IPR014776; 4pyrrole_Mease_sub2.
DR InterPro; IPR012818; CbiE.
DR InterPro; IPR006365; Cbl_synth_CobL.
DR InterPro; IPR014008; Cbl_synth_MTase_CbiT.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR NCBIfam; TIGR02467; CbiE; 1.
DR NCBIfam; TIGR02469; CbiT; 1.
DR PANTHER; PTHR43182; COBALT-PRECORRIN-6B C(15)-METHYLTRANSFERASE (DECARBOXYLATING); 1.
DR PANTHER; PTHR43182:SF1; COBALT-PRECORRIN-7 C(5)-METHYLTRANSFERASE; 1.
DR Pfam; PF00590; TP_methylase; 1.
DR PIRSF; PIRSF036428; CobL; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR SUPFAM; SSF53790; Tetrapyrrole methylase; 1.
PE 3: Inferred from homology;
KW Cobalamin biosynthesis {ECO:0000256|ARBA:ARBA00022573};
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000313|EMBL:KOU45098.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000037699};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:KOU45098.1}.
FT DOMAIN 23..207
FT /note="Tetrapyrrole methylase"
FT /evidence="ECO:0000259|Pfam:PF00590"
FT REGION 421..441
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 441 AA; 46100 MW; D8FCA94BF9CDA37A CRC64;
MRVHPLPLPR GPAVSSAPPT LPVTVVGLGA DGWAGLTAAA RTALTSAEVL IGGPRQLDLL
PADVCPGERI AWPSPLRPAV PKLTAEHAGR RIAVLASGDP MFYGIGRALC EELGPHALHV
LPHPSSVSYA CARLGWPVED TEVVTIVGRP VAQLAAALYE GRRVLVLSAG AGSPGEIAAL
LRERGFGPSR MRVLERLGSE HEDAYEGHAD GWDRAPGDPL NVVAVDCRRD PAAPTPRLGT
TPGLPDTAYE HDGQLTKRHV RAATLCALAP APGELLWDIG GGSGSIGIEW MRSHPSCRAV
AVERVPERAE RITRNAGALG VPGLRVVLGA APDALIGLPA PDAVFIGGGL TAPGLLDAAW
TALAPGGRLV VNTVTLESEA VLGDHYRRRG GELVKLAVAH AVPVGGFTGW RQAMAVTQWS
VTKPHPTTDR TTENENDKDQ T
//
