ID A0A0M9YNF7_9ACTN Unreviewed; 1177 AA.
AC A0A0M9YNF7;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 09-DEC-2015, sequence version 1.
DT 24-JAN-2024, entry version 37.
DE RecName: Full=Transcription-repair-coupling factor {ECO:0000256|HAMAP-Rule:MF_00969};
DE Short=TRCF {ECO:0000256|HAMAP-Rule:MF_00969};
DE EC=3.6.4.- {ECO:0000256|HAMAP-Rule:MF_00969};
GN Name=mfd {ECO:0000256|HAMAP-Rule:MF_00969};
GN ORFNames=ADK56_04190 {ECO:0000313|EMBL:KOU54108.1};
OS Streptomyces sp. MMG1522.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1415545 {ECO:0000313|EMBL:KOU54108.1, ECO:0000313|Proteomes:UP000037713};
RN [1] {ECO:0000313|EMBL:KOU54108.1, ECO:0000313|Proteomes:UP000037713}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MMG1522 {ECO:0000313|EMBL:KOU54108.1,
RC ECO:0000313|Proteomes:UP000037713};
RA Noorani M.;
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Couples transcription and DNA repair by recognizing RNA
CC polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent
CC release of RNAP and its truncated transcript from the DNA, and
CC recruitment of nucleotide excision repair machinery to the damaged
CC site. {ECO:0000256|HAMAP-Rule:MF_00969}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00969}.
CC -!- SIMILARITY: In the C-terminal section; belongs to the helicase family.
CC RecG subfamily. {ECO:0000256|HAMAP-Rule:MF_00969}.
CC -!- SIMILARITY: In the N-terminal section; belongs to the UvrB family.
CC {ECO:0000256|HAMAP-Rule:MF_00969}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KOU54108.1}.
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DR EMBL; LGDF01000036; KOU54108.1; -; Genomic_DNA.
DR RefSeq; WP_030115459.1; NZ_LGDF01000036.1.
DR AlphaFoldDB; A0A0M9YNF7; -.
DR GeneID; 63980426; -.
DR PATRIC; fig|1415545.3.peg.921; -.
DR Proteomes; UP000037713; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003684; F:damaged DNA binding; IEA:InterPro.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:UniProtKB-UniRule.
DR GO; GO:0000716; P:transcription-coupled nucleotide-excision repair, DNA damage recognition; IEA:UniProtKB-UniRule.
DR CDD; cd17991; DEXHc_TRCF; 1.
DR Gene3D; 2.40.10.170; -; 1.
DR Gene3D; 3.40.50.11180; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 3.30.2060.10; Penicillin-binding protein 1b domain; 1.
DR Gene3D; 3.90.1150.50; Transcription-repair-coupling factor, D7 domain; 1.
DR HAMAP; MF_00969; TRCF; 1.
DR InterPro; IPR003711; CarD-like/TRCF_RID.
DR InterPro; IPR036101; CarD-like/TRCF_RID_sf.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR004576; Mfd.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR047112; RecG/Mfd.
DR InterPro; IPR037235; TRCF-like_C_D7.
DR InterPro; IPR005118; TRCF_C.
DR InterPro; IPR041471; UvrB_inter.
DR NCBIfam; TIGR00580; mfd; 1.
DR PANTHER; PTHR47964; ATP-DEPENDENT DNA HELICASE HOMOLOG RECG, CHLOROPLASTIC; 1.
DR PANTHER; PTHR47964:SF1; ATP-DEPENDENT DNA HELICASE HOMOLOG RECG, CHLOROPLASTIC; 1.
DR Pfam; PF02559; CarD_TRCF_RID; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF03461; TRCF; 1.
DR Pfam; PF17757; UvrB_inter; 1.
DR SMART; SM01058; CarD_TRCF; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SMART; SM00982; TRCF; 1.
DR SUPFAM; SSF141259; CarD-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
DR SUPFAM; SSF143517; TRCF domain-like; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW Rule:MF_00969}; Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00969};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_00969};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_00969};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW Rule:MF_00969}; Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|HAMAP-Rule:MF_00969};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_00969}.
FT DOMAIN 642..803
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 828..978
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
SQ SEQUENCE 1177 AA; 128660 MW; 1F3C8AC44F8F2FBF CRC64;
MSLHGLLDVV VTDPALAEAV KAAGDGHRAH VDLVGPPGAR PFAVAALARQ TGRTVLAVTA
TGREAEDLAA ALRTLLPPDT VAEYPSWETL PHERLSPRSD TVGRRLAVLR RLAHPREDDP
ETGPVSVVVA PIRSVLQPQV KGLGELEPVS LESGQSADLG EVVEALAAAA YARVELVEKR
GEFAVRGGIL DVFPPTEEHP LRVEFWGDDV EEIRYFKIAD QRSLEVAAHG LWAPPCRELL
LTDQVRERAA VLAEEHPELG ELLGKIAEGI AVEGMESLAP VLVDDMELLL DVLPKGAMAI
VCDPERVRTR AADLVATSQE FLQASWAASA GGGEAPIDVG AASLWGIADV RDRARELGMM
WWTVSPFAAD AADHDDDTLQ LSMHAPEAYR GDTARALADT KGWLADGWRT VYVTEGQGLA
SRTVEVLGGE GIAARLDADL TEITPSLVHV SCGAIDQGFV DPALKLAVLT ETDLTGQRTA
TKDLGRMPAR RRKTIDPLTL EVGDYIVHEQ HGVGRYVEMV QRTVQGATRE YLLVEYAPAK
RGQPGDRLYI PTDQLEQVTK YVGGEAPTLH RLGGADWTKT KQRAKKAVKE IAADLIKLYS
ARMAAPGHAF GADTPWQREL EDAFPYAETP DQLSTIAEVK EDMEKTVPMD RLICGDVGYG
KTEIAVRAAF KAVQDGKQVA VLVPTTLLVQ QHYGTFTERY SQFPVNVRAL SRFQSEAESK
ATLEGLKDGS VDLVIGTHRL FSSETKFKDL GLVIVDEEQR FGVEHKEQLK KLRANVDVLT
MSATPIPRTL EMAVTGIREM STITTPPEER HPVLTFVGPY EEKQIGAAVR RELLREGQVF
YIHNRVESID RAAARLREIV PEARIATAHG QMSEQALEQV VVDFWEKKFD VLVSTTIVES
GIDISNANTL IVERGDNFGL SQLHQLRGRV GRGRDRGYAY FLYPPEKPLT ETAHERLATI
AQHTEMGAGM YVAMKDLEIR GAGNLLGGEQ SGHIAGVGFD LYVRMVGEAV ADYRAQMEGG
VEEEPPLEVK IELPVDAHVP HDYAPGERLR LQAYRAIASA TSEDDIRAVR EELTDRYGPL
PEPVENLLLV AGLRMLARAC GVGEIVLQGS NIRFAPVELR ESQELRLKRL HPKALIKPAA
HQILVPRPTT GRIGGKPVIG RELLSWTGEF LTTILGS
//
