ID A0A0M9ZH42_9ACTN Unreviewed; 796 AA.
AC A0A0M9ZH42;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 09-DEC-2015, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=non-specific serine/threonine protein kinase {ECO:0000256|ARBA:ARBA00012513};
DE EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
GN ORFNames=ADL00_27755 {ECO:0000313|EMBL:KOV55983.1};
OS Streptomyces sp. AS58.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1519489 {ECO:0000313|EMBL:KOV55983.1, ECO:0000313|Proteomes:UP000037758};
RN [1] {ECO:0000313|EMBL:KOV55983.1, ECO:0000313|Proteomes:UP000037758}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AS58 {ECO:0000313|EMBL:KOV55983.1,
RC ECO:0000313|Proteomes:UP000037758};
RA Noorani M.;
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-
CC [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-
CC COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001433};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
CC threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
CC Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
CC EC=2.7.11.1; Evidence={ECO:0000256|ARBA:ARBA00000775};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KOV55983.1}.
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DR EMBL; LGDU01000341; KOV55983.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0M9ZH42; -.
DR PATRIC; fig|1519489.3.peg.6229; -.
DR Proteomes; UP000037758; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0016043; P:cellular component organization; IEA:UniProt.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd14014; STKc_PknB_like; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 3.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR018391; PQQ_beta_propeller_repeat.
DR InterPro; IPR002372; PQQ_repeat.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR011047; Quinoprotein_ADH-like_supfam.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR22983; PROTEIN KINASE RELATED; 1.
DR PANTHER; PTHR22983:SF6; SERINE_THREONINE-PROTEIN KINASE 36; 1.
DR Pfam; PF00069; Pkinase; 1.
DR Pfam; PF01011; PQQ; 1.
DR Pfam; PF13360; PQQ_2; 1.
DR Pfam; PF13570; PQQ_3; 2.
DR SMART; SM00564; PQQ; 9.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR SUPFAM; SSF50998; Quinoprotein alcohol dehydrogenase-like; 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU10141};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:KOV55983.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Reference proteome {ECO:0000313|Proteomes:UP000037758};
KW Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527,
KW ECO:0000313|EMBL:KOV55983.1}; Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 29..284
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REGION 304..356
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 328..352
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 57
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 796 AA; 83466 MW; 5E9FD229F6A42FDE CRC64;
MEVARLVRGG GRQVVDQLTQ HDPRRIGPFE VLGRLGAGGM GLVYLARSAS GRRVAIKTVR
TELAEDQLFR VRFTREVEAA RAVSGFYTAA VVDADPRAAV PWLATAYVPA PSLEEIVNDC
GPLPAQAVRW LAAGVAEALQ SIHGAGLVHR DLKPSNVLVV EDGPRVIDFG IASGVSNTRL
TMTNVAVGTP AYMSPEQAKD SRSVTGASDV FSLGSTLVFA ATGHPPFHGA NPVETVFMLL
REGPDLEGLP DELRPLIESC MQMDPSARPT PADLQAQLAP HLFGSGSDDS GTASAWLPEK
AVGLIETRRG GRPAVRPAPG TGRSAGRPHA VPPPPSHDPV VPAPPVPAPV GAPDGGPVRL
AGAPMPIGPG PRVADARAAA VKAPPPEAGL VASWSRPRPG VNGAEPAVPA AAPPPLPESP
AGWRPWRFRM SNDVWGTPAV ADDLVYVTSF EVHALDVATG RRRFKTRDVA WSMAVADGRV
HASDGPTLFA LDAREGGDLW RLSTDAWVYS LKAERGTVVT GTRGGGVQAW EAASGLKLWE
IGGCQSDFES PEAGPALHDG TVYVWQDARL RALDARTGDE RWSYPIGDAA SCGGVPVRIT
PAPDGYVYVC AGTRVLAVEA AGGHVRWHFE APAVFLSPPA FAPGPAVTGG GVYLADYLGT
VYALDATDGR DRWRIATESR SSIEPVLVAA GHVHVGSGTG LYTLDAVTGT PKWRFQAGGD
IVGSPSVAEG RIHFGSTDHL LYTLKADDGR LRWKLATGGE ITGSPVVKDG IVYACSKDRC
VYALDAEKGT GTARTA
//
