ID A0A0N0A8S7_9ACTN Unreviewed; 674 AA.
AC A0A0N0A8S7;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 09-DEC-2015, sequence version 1.
DT 24-JAN-2024, entry version 29.
DE SubName: Full=Squalene-hopene cyclase {ECO:0000313|EMBL:KOV95435.1};
GN ORFNames=ADL04_20290 {ECO:0000313|EMBL:KOV95435.1};
OS Streptomyces sp. NRRL B-3648.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1519493 {ECO:0000313|EMBL:KOV95435.1, ECO:0000313|Proteomes:UP000037702};
RN [1] {ECO:0000313|EMBL:KOV95435.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NRRL B-3648 {ECO:0000313|EMBL:KOV95435.1};
RA Noorani M.;
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Secondary metabolite biosynthesis; hopanoid biosynthesis.
CC {ECO:0000256|ARBA:ARBA00004999}.
CC -!- SIMILARITY: Belongs to the terpene synthase family.
CC {ECO:0000256|ARBA:ARBA00006333}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KOV95435.1}.
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DR EMBL; LGDZ01000188; KOV95435.1; -; Genomic_DNA.
DR RefSeq; WP_053709881.1; NZ_LGDZ01000188.1.
DR AlphaFoldDB; A0A0N0A8S7; -.
DR PATRIC; fig|1519493.3.peg.4324; -.
DR OrthoDB; 9758578at2; -.
DR UniPathway; UPA00337; -.
DR Proteomes; UP000037702; Unassembled WGS sequence.
DR GO; GO:0005811; C:lipid droplet; IEA:InterPro.
DR GO; GO:0016866; F:intramolecular transferase activity; IEA:InterPro.
DR GO; GO:0016104; P:triterpenoid biosynthetic process; IEA:InterPro.
DR CDD; cd02892; SQCY_1; 1.
DR Gene3D; 1.50.10.20; -; 2.
DR InterPro; IPR006400; Hopene-cyclase.
DR InterPro; IPR032696; SQ_cyclase_C.
DR InterPro; IPR032697; SQ_cyclase_N.
DR InterPro; IPR018333; Squalene_cyclase.
DR InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
DR NCBIfam; TIGR01507; hopene_cyclase; 1.
DR NCBIfam; TIGR01787; squalene_cyclas; 1.
DR PANTHER; PTHR11764:SF20; LANOSTEROL SYNTHASE; 1.
DR PANTHER; PTHR11764; TERPENE CYCLASE/MUTASE FAMILY MEMBER; 1.
DR Pfam; PF13243; SQHop_cyclase_C; 1.
DR Pfam; PF13249; SQHop_cyclase_N; 1.
DR SFLD; SFLDG01016; Prenyltransferase_Like_2; 1.
DR SUPFAM; SSF48239; Terpenoid cyclases/Protein prenyltransferases; 2.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000037702};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 42..326
FT /note="Squalene cyclase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF13249"
FT DOMAIN 337..653
FT /note="Squalene cyclase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13243"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 674 AA; 74622 MW; 297B41CD176BA372 CRC64;
MTATTDGSTG ATLPSRAAAA SDTTLITPET AGVQEAAAGA ARRATDFLLA TQDAQGWWKG
DLETNVTMDA EDLLLRQFLG ILDEETVRAA AKFIRGEQRE DGTWATFYGG PGELSTTVEA
YVALRLAGDA PDAPHMAKAS AWVRERGGIA AARVFTRIWL ALFGWWKWED LPELPPELIY
FPTWFPLNIY NFGCWARQTI VPLTIVSAKR PVRPAPFALD ELHTDPANPN PPQPPAPVAS
WDGVFQRLDK VVRGYRRVAV RRLRRAAMNS AARWIIERQE NDGCWGGIQP PAVYSVIALH
LLGYDLEHPV LREGLASLDR FAVWREDGAR MIEACQSPVW DTCLATIALV DAGLPVDHPQ
LVKAADWMLG EEIVRPGDWA VRRPHLPPGG WAFEFHNDNY PDIDDTAEVA LALRRVRHHD
PERVDKAIGR AVRWNLGMQS KNGAWGAFDV DNTSPFPNRL PFCDFGEVID PPSADVTAHV
VEMLAAEGLA HDPRTRRGID WLLAEQEPNG SWFGRWGVNY IYGTGSVVPA LTAAGLPGSH
PAIRRAVAWL ESVQNDDGGW GEDLRSYKYA KEWSGRGAST PSQTAWALMA LLAAGEKESE
AVERGVRWLA GTQRADGTWD EPYFTGTGFP WDFSINYHLY RQVFPLTALG RYLHGDPFER
RLLTRKPLSG AKVS
//
