ID A0A0N0AIS7_9ACTN Unreviewed; 389 AA.
AC A0A0N0AIS7;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 09-DEC-2015, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=Acetyl-CoA acetyltransferase {ECO:0000313|EMBL:KOX09976.1};
GN ORFNames=ADL05_24860 {ECO:0000313|EMBL:KOX09976.1};
OS Nocardiopsis sp. NRRL B-16309.
OC Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
OC Nocardiopsaceae; Nocardiopsis.
OX NCBI_TaxID=1519494 {ECO:0000313|EMBL:KOX09976.1, ECO:0000313|Proteomes:UP000037694};
RN [1] {ECO:0000313|Proteomes:UP000037694}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NRRL B-16309 {ECO:0000313|Proteomes:UP000037694};
RA Ju K.-S., Doroghazi J.R., Metcalf W.W.;
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the thiolase-like superfamily. Thiolase family.
CC {ECO:0000256|ARBA:ARBA00010982, ECO:0000256|RuleBase:RU003557}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KOX09976.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; LGEC01000114; KOX09976.1; -; Genomic_DNA.
DR RefSeq; WP_053619420.1; NZ_LGEC01000114.1.
DR AlphaFoldDB; A0A0N0AIS7; -.
DR STRING; 1519494.ADL05_24860; -.
DR PATRIC; fig|1519494.3.peg.5429; -.
DR OrthoDB; 3761315at2; -.
DR Proteomes; UP000037694; Unassembled WGS sequence.
DR GO; GO:0016747; F:acyltransferase activity, transferring groups other than amino-acyl groups; IEA:InterPro.
DR CDD; cd00751; thiolase; 1.
DR Gene3D; 3.40.47.10; -; 2.
DR InterPro; IPR002155; Thiolase.
DR InterPro; IPR016039; Thiolase-like.
DR InterPro; IPR020617; Thiolase_C.
DR InterPro; IPR020613; Thiolase_CS.
DR InterPro; IPR020616; Thiolase_N.
DR NCBIfam; TIGR01930; AcCoA-C-Actrans; 1.
DR PANTHER; PTHR43365; BLR7806 PROTEIN; 1.
DR PANTHER; PTHR43365:SF1; STEROID 3-KETOACYL-COA THIOLASE FADA6; 1.
DR Pfam; PF02803; Thiolase_C; 1.
DR Pfam; PF00108; Thiolase_N; 1.
DR PIRSF; PIRSF000429; Ac-CoA_Ac_transf; 1.
DR SUPFAM; SSF53901; Thiolase-like; 2.
DR PROSITE; PS00737; THIOLASE_2; 1.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000256|RuleBase:RU003557};
KW Reference proteome {ECO:0000313|Proteomes:UP000037694};
KW Transferase {ECO:0000256|RuleBase:RU003557, ECO:0000313|EMBL:KOX09976.1}.
FT DOMAIN 5..258
FT /note="Thiolase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00108"
FT DOMAIN 267..388
FT /note="Thiolase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02803"
FT ACT_SITE 91
FT /note="Acyl-thioester intermediate"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
FT ACT_SITE 345
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
FT ACT_SITE 375
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
SQ SEQUENCE 389 AA; 40256 MW; 3D19E083B4D034C6 CRC64;
MPEAVIVDAV RTPIGKGKPS GALHDVNAVD LLAHSLEALV ERTGLDPALV DDVIGGVVTQ
HGEQAANMTR RALLAAGYPE SVPATTVDRQ CGSSQQAVHF AAQGVIAGAY DIVVAAGVES
MGRVPMGTNL TGSADPLGSG FAKRYPEGLV GQGVAAELIA ARWGLSRRRM DEFALTSHAR
AADATRRGAF EGQLAPIGGL TADEGIREGG TPDSLAALRP AYHDEDTAAR FPQITWDVTA
GNASPLSDGS AAVLIMSAQR AAELGLRPLA RLHSFAVAAD DPLYMLTAVI PSTRRVLDRA
GLSMDDIDLF EINEAFASVV LAWAAETGAD LDRVNVNGGA IALGHPLGAS GARLMTTLVH
GLHEHGGRYG LQAMCEAGGL SNATVVERL
//
