ID A0A0N0BH68_9HYME Unreviewed; 2685 AA.
AC A0A0N0BH68;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 09-DEC-2015, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=Adenomatous polyposis coli protein {ECO:0000313|EMBL:KOX75788.1};
GN ORFNames=WN51_12576 {ECO:0000313|EMBL:KOX75788.1};
OS Melipona quadrifasciata.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Apoidea;
OC Anthophila; Apidae; Melipona.
OX NCBI_TaxID=166423 {ECO:0000313|EMBL:KOX75788.1, ECO:0000313|Proteomes:UP000053105};
RN [1] {ECO:0000313|EMBL:KOX75788.1, ECO:0000313|Proteomes:UP000053105}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=0111107301 {ECO:0000313|EMBL:KOX75788.1};
RC TISSUE=Whole body {ECO:0000313|EMBL:KOX75788.1};
RA Pan H., Kapheim K.;
RT "The genome of Melipona quadrifasciata.";
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the adenomatous polyposis coli (APC) family.
CC {ECO:0000256|ARBA:ARBA00009051}.
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DR EMBL; KQ435758; KOX75788.1; -; Genomic_DNA.
DR STRING; 166423.A0A0N0BH68; -.
DR OrthoDB; 2963825at2759; -.
DR Proteomes; UP000053105; Unassembled WGS sequence.
DR GO; GO:0071944; C:cell periphery; IEA:UniProt.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR GO; GO:0043229; C:intracellular organelle; IEA:UniProt.
DR GO; GO:0008013; F:beta-catenin binding; IEA:InterPro.
DR GO; GO:0016043; P:cellular component organization; IEA:UniProt.
DR GO; GO:0030178; P:negative regulation of Wnt signaling pathway; IEA:InterPro.
DR GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR009240; APC_15aa_rpt.
DR InterPro; IPR026818; Apc_fam.
DR InterPro; IPR041257; APC_rep.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000225; Armadillo.
DR PANTHER; PTHR12607; ADENOMATOUS POLYPOSIS COLI PROTEIN FAMILY; 1.
DR PANTHER; PTHR12607:SF12; APC-LIKE, ISOFORM A-RELATED; 1.
DR Pfam; PF05972; APC_15aa; 1.
DR Pfam; PF18797; APC_rep; 1.
DR Pfam; PF00514; Arm; 2.
DR SMART; SM00185; ARM; 7.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR PROSITE; PS50176; ARM_REPEAT; 3.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000053105};
KW Wnt signaling pathway {ECO:0000256|ARBA:ARBA00022687}.
FT REPEAT 396..434
FT /note="ARM"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
FT REPEAT 638..672
FT /note="ARM"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
FT REPEAT 687..729
FT /note="ARM"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
FT REGION 1..41
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 230..293
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 971..999
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1071..1103
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1338..1373
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1399..1426
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2086..2290
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2333..2371
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2391..2440
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2464..2496
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 7..32
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 238..284
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 973..996
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1071..1090
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1348..1365
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2094..2118
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2125..2142
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2152..2168
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2178..2238
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2257..2290
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2348..2370
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2392..2410
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2421..2440
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2685 AA; 296506 MW; 7FA6C2351C8F7634 CRC64;
MPGENRGRSL RQTTPSGVTE TTTPSSKASE LEVRTRGGSM IPLPRCAMNM PQNPKTVKTE
KNRLRLIMEN SRGLADTLKK ERRINVDEDE ENYRVSSVNE PATPRYCDLS CNVYRCPVRK
EDCQKRAERL LSEECRVSRG TIGVGVEGVG SWRAQRRPRD IEISTPLSGV AAHELESSVD
GAAFNPVAAA ATTSARCSLV KAALKTPSSS SSSSASPPVN VHARPRLYLG PVISETSKED
AMEPEVKEED ERRSSTPSPE IYTRRNKRYN EGGSSEEDSK PDTSLQGHRL PSSYRGTWPI
RRDVWANQQM GFSTQQSTST TVHNDVASVM SFSSNSGGAL GCSTEMQGDR RLGAKVDVVY
NLLGMLGSTE GREDMSATLL SMSSSIDNCL IMRQSGCLPL LVQLIHAPGQ DPETREKASR
ALHNIVYAKS DERAGRREAR VLRFLEQLRD YCQALRTSLE TGQVPDDLER HPGPTIAALM
KLSFDEAHRH AMCQLGGLHA VAELIEMDHM AHGSECDDQN CITLRRYAGM ALTNLTFGDG
NNKALLCSFR EFMKALVSQL RSPSDDLRQV TASVLRNLSW RADTSSKQTL REVGAVTGLM
KAAMEGRKES TLKSILSALW NLSAHCSTNK VDICAVDGAL AFLVDMLSYK APSKTLAIVE
NAGGILRNVS SHIAVREDYR AIVRERGCLQ VLLQQLRSPS LTVVSNACGA LWNLSARCPQ
DQRLLWDLGA VPMLRSLIHS KHKMISMGSS AALKNLLSAR PGCNNLVHLD STARGLGLPT
LPTLVARRQR ALEQEIDQNL AETCDNIEPS TSPTNKDDKF LFKVEHSFLG INATRTLRSY
QLHNQPGTSN LAKCNGVARS ESRDSMRSVT STHSDTMFER VNRHVLNGLS PTDVQMKQQS
SSLHSAAISP TIAHRTEGNL FSDYAETDLD QPTDYSLRYA ERSLEDEEKP HSHYFPNNDQ
ELIHEDTVKT YCTEGTPHGT SLNSSRAASA SDLQEDSRQR SLLKRIQEQG KLQDKEELTL
ECTNDVLNDK EGNQALRYFE TNIKDTNVEE GDRVSVKNSL SLRTTLTQVP SGNLQYDESD
NIASNSTKNK PDMQKKYDTH DHKFDKNYPN NGVNLYVANA LKASNDSGYQ VSDGDEDDED
LLTACINIGM QNNRHRHSFI GNNFEKVSRN ESNLARYQTS VALDQMEYNS SIDSTMNSLD
TKRSGSEEII NPDICIDNNV NDNSSDMNIV SDYNQSPDKF MQKIVETRIP MQQSNRNLQN
ELDKVTNTEH SSILGDDNLY LRNSPILHET VVFNTEPTQQ QYLSSIDTHS NEDMSSLIHN
DLIDNDQNID DDCVKWENER TSENSRDKPT ENSPMQQSYA KDSESSESID SVEQSEHALL
ELCIQPGLTK AMDNIQLTNT SGSSRVDDEF GDRQIGSSND SKKAYNDTCE VDGVRKEEVD
SKYKQKLTDS TKHVEKEEVY RRQRDPDAMI ASLDRLTATL VQQTEAIRER DSSTMKQSIL
SDTWNEDSPN DVSFPSISIS APIIASFKSD VPEEPGTVTS ECYETASSES GHMTSSRIIQ
REAIKLAEAV DAEMNRQNEL DATSITSMDL EAIKPPSSMG SLLSLTASYA GSGDCSESFN
RDRCNSASLP PVQVKNQVSS SESRNCRKKS LPLGVVAKRA LSQTQSHAGS LENLLNECTG
SHLESVKPPS MMDELPDVGD MENSMLSVAS ITSEVADSKY QDTQNLSGSD AVFDLLKPVA
NVLSMTCMRY AEAMQNSANN SMSECLENIN PPSLFNEVCE MDESTMEQAT ETICSDTLCI
DAELHTEEAP HPVTIDRIDE AGDTDEAVTP ISSEYCVTSS AESTPRKRLP RNLTPKQKRT
MAKERYKTYT IAAELDKKEE EQQRRENVVE EKIARGKISP FSKLTPKQRR QEDRARFQTQ
VLENPFPDTN HDQNNQQDVN AVCEQENSVK PAPEAMSPVK SAIPTLTKLS ACKTLIKKRA
EQKKNRERYR TRTLNDSERI FRDSEGNCAD STHNIEPDEI QTMLEQNATI VLNTLNESNK
ASETGEDGLL DCETISLVSN ESESERNLRM RFVNGVSKKL IGSCAQQMNG TREPEETTEI
EEASLQEDRL RYNENVETES EDESNNTEGP PRETKRPRII KPGMVRDPSN DSNATDKSDP
ESPKAIRGRR KALYSNPITR KPTPQSSPLK QVNPVSGIPI GRSNTSPIVR ATRATTLRQN
NNSPGVGTKE SAKSKTIAPN STDDKRTKMS VAAKRASVPQ KGSSLTFTKS VKRHSTPPTC
SSSNYQQETK TDVTVKPLER QGTFTKDEPE VENAPTVVSS SSSPIKTKIA KPIRGATSKV
HPTTGKPKIS PKTHQAHQSK SSSKAIPSEK IQSSKALPLL VAPKRLPTGK VTATPKISTA
NNQNVSAQAE SGKAFRKIGP LGQRSNSNSS IVSNSSTSMQ TRKLAKEATS KIASLWKKVE
ESKNRQRFEK PDTRQWLQPG NCANEVDASP SPASDPRFRL FRSSTFEGMP QENDHPESAL
CKSKLKRPLV IGLQPSKVKY RNSCDLSGMN ASDAPCKIPV KSGEASSHKR DTVDVGDTTS
VVLRKSQNTD TSATEVDPTK RISRLGSFIR VDPANAEGSA QGYVNGTGVR TPASAIVPPF
NYNPKQDVPS QIAKVTPDET ESKFKVATDC HSSDIVTGST RVTTV
//