ID A0A0N0BHY5_9HYME Unreviewed; 3921 AA.
AC A0A0N0BHY5;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 09-DEC-2015, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE SubName: Full=Dynein heavy chain 7, axonemal {ECO:0000313|EMBL:KOX76888.1};
GN ORFNames=WN51_10744 {ECO:0000313|EMBL:KOX76888.1};
OS Melipona quadrifasciata.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Apoidea;
OC Anthophila; Apidae; Melipona.
OX NCBI_TaxID=166423 {ECO:0000313|EMBL:KOX76888.1, ECO:0000313|Proteomes:UP000053105};
RN [1] {ECO:0000313|EMBL:KOX76888.1, ECO:0000313|Proteomes:UP000053105}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=0111107301 {ECO:0000313|EMBL:KOX76888.1};
RC TISSUE=Whole body {ECO:0000313|EMBL:KOX76888.1};
RA Pan H., Kapheim K.;
RT "The genome of Melipona quadrifasciata.";
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the dynein heavy chain family.
CC {ECO:0000256|ARBA:ARBA00008887}.
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DR EMBL; KQ435737; KOX76888.1; -; Genomic_DNA.
DR STRING; 166423.A0A0N0BHY5; -.
DR OrthoDB; 166463at2759; -.
DR Proteomes; UP000053105; Unassembled WGS sequence.
DR GO; GO:0005929; C:cilium; IEA:UniProtKB-KW.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR Gene3D; 1.10.287.2620; -; 1.
DR Gene3D; 1.10.472.130; -; 1.
DR Gene3D; 1.10.8.1220; -; 1.
DR Gene3D; 1.10.8.710; -; 1.
DR Gene3D; 1.20.1270.280; -; 1.
DR Gene3D; 1.20.58.1120; -; 1.
DR Gene3D; 1.20.920.20; -; 1.
DR Gene3D; 1.20.920.30; -; 1.
DR Gene3D; 3.10.490.20; -; 1.
DR Gene3D; 6.10.140.1060; -; 1.
DR Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 5.
DR Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR035706; AAA_9.
DR InterPro; IPR041658; AAA_lid_11.
DR InterPro; IPR042219; AAA_lid_11_sf.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR041589; DNAH3_AAA_lid_1.
DR InterPro; IPR042222; Dynein_2_N.
DR InterPro; IPR043157; Dynein_AAA1S.
DR InterPro; IPR041466; Dynein_AAA5_ext.
DR InterPro; IPR041228; Dynein_C.
DR InterPro; IPR043160; Dynein_C_barrel.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR InterPro; IPR013602; Dynein_heavy_linker.
DR InterPro; IPR042228; Dynein_linker_3.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR45703; DYNEIN HEAVY CHAIN; 1.
DR PANTHER; PTHR45703:SF1; DYNEIN HEAVY CHAIN; 1.
DR Pfam; PF12774; AAA_6; 1.
DR Pfam; PF12775; AAA_7; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF12781; AAA_9; 1.
DR Pfam; PF17857; AAA_lid_1; 1.
DR Pfam; PF18198; AAA_lid_11; 1.
DR Pfam; PF08393; DHC_N2; 1.
DR Pfam; PF17852; Dynein_AAA_lid; 1.
DR Pfam; PF18199; Dynein_C; 1.
DR Pfam; PF03028; Dynein_heavy; 1.
DR Pfam; PF12777; MT; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Cilium {ECO:0000256|ARBA:ARBA00023069};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Dynein {ECO:0000256|ARBA:ARBA00023017};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000053105}.
FT DOMAIN 609..1015
FT /note="Dynein heavy chain linker"
FT /evidence="ECO:0000259|Pfam:PF08393"
FT DOMAIN 1147..1473
FT /note="Dynein heavy chain hydrolytic ATP-binding dynein
FT motor region"
FT /evidence="ECO:0000259|Pfam:PF12774"
FT DOMAIN 1664..1795
FT /note="Dynein heavy chain AAA 5 extension"
FT /evidence="ECO:0000259|Pfam:PF17852"
FT DOMAIN 2022..2094
FT /note="Dynein heavy chain 3 AAA+ lid"
FT /evidence="ECO:0000259|Pfam:PF17857"
FT DOMAIN 2183..2445
FT /note="Dynein heavy chain AAA module D4"
FT /evidence="ECO:0000259|Pfam:PF12780"
FT DOMAIN 2459..2797
FT /note="Dynein heavy chain coiled coil stalk"
FT /evidence="ECO:0000259|Pfam:PF12777"
FT DOMAIN 2831..3052
FT /note="Dynein heavy chain ATP-binding dynein motor region"
FT /evidence="ECO:0000259|Pfam:PF12781"
FT DOMAIN 3319..3433
FT /note="Dynein heavy chain region D6 P-loop"
FT /evidence="ECO:0000259|Pfam:PF03028"
FT DOMAIN 3468..3608
FT /note="Dynein heavy chain AAA lid"
FT /evidence="ECO:0000259|Pfam:PF18198"
FT DOMAIN 3614..3917
FT /note="Dynein heavy chain C-terminal"
FT /evidence="ECO:0000259|Pfam:PF18199"
FT COILED 2488..2515
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2687..2749
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 3921 AA; 453942 MW; 2812533650724576 CRC64;
MEESVIVENN DDILRYYYYL TRGIDDTYVG PMDVDLLKNI LRRIPTKWKD KFKESVNRLV
KEVKEGYILN VKKSVIEFVI GDSTYSSLKQ FTVFEKNEQF ERIRFPKEHK VNYRWNRARL
EKRIILYRPV VRRIFDYWYR EFSDCKLISG RELAARETSY DLGSFERIIS KMCSGIKEEL
VKHWLPKIQG ILIAAFERNE LPLTMTGDTS SHRRFFNCIG FIMEDQLRGV YLRSVEEYLD
YLYDRNNTCR GFDIKVTVRN SSVLFEPTFK VFSETFSTIL NLLGETVSTL PRIETLLNIS
SIVVDRKLLQ PYISEECLKK HAKEIGRLID REKVGPITQL SEFEKYATFI NDSETDKVQE
FLKYDTAENF EKYQTLIASY DRLSRFVKVE YNRTYFAGFF VVHRGEIIKY IVSVALKLKE
ELIGKMISEY QQKSRAIGNE YQRIVDRALS VPINTRELID LRKFINITET ETTGELENRL
REIIKYILVL SDFSILSPVE LKINNFAFQW YYKLADIFEQ HRAIVVSKIG EFQNILKKKI
EQFERELEIY AKYCNELQYW GNIEEIYRYK KKADRLENKL ITAMDTIDGF NEEEELFGWE
LSQYPLRKTT ADKLAPYKRL YDTTCEFLTN YNTWMNSMIG SYEPETIETA TAIAYRTIYR
LERSIQEPIT KKLVETIRTK IEEFKEHMPV IATLGNPSLK SRHWEQISEI VGFPIKVDES
MTLAKILDYG LADYVTKFEG ISEAATKEGN LERALVRMHL DWTEIAFVVN PYRDTGTYVI
ASIDDIQLLL DDHLIKAQTM KNSLYIKPFE KETLDWESKL LLLQSIIDYW LQVQAIWMYL
EPIFSSPDIQ QQMPEEGRRE ENSKTVINYI QIWREIMLSV AADPRVMSVV EIDKMLERLK
KCINLLDLIQ KGLTAYLEKK RLYFPRFFFL SNDELLEILS ETKDPTRVQP HLKKCFEGIA
QVNFTVDLEI TVIKSSEEEE IILQDIIDTT AARGQVEKWL LELESSMKKS VKAQVVLAKD
AYLKQIRSKW ALEWPGQTIL CISKLYWTAD VTAVLSKMDL MDLKNYIDNC TNELNEIVKL
VRGTLPMQNR ITLVYLVTMD VHSRDVVAEL YKERVITATD FKWLAQLRYY WMDEDLWSTM
INTSLKYAYE YLGNTSRLVI TPLTDRCYRT LFSALSLHLG GAPEGPAGTG KTETTKDLAK
AVAKQCVVFN CSEGLDYIAL GKFFKGLAST GAWSCFDEFN RIDLEVLSVV AQQILTIQRA
INAGLTKLDF ENTEIKLDPT CAVFITMNPG YAGRTELPDN LKALFRPVAM MVPDYALIAE
NTLYSYGFYE ARPLSIKIVT AYRLCSEQLS SQNHYDYGMR AVKSVLIAAG NLKIKYPEEN
ENILILRSIK DVNLPKFLSE DLPLFNGIMS DLFPGIELPE PDYTDLNTCI YDACSASNLQ
CNAWFLEKIQ QIYEMMIIRH GFMIVGFPFA GKTAAYNVLA NALKLCEERN LINEHKVEMF
VINPKAVTLG QLYGQFDPIS REWSDGVLAI SYRAFATSTN ENRKWLIFDG PIDAVWIESM
NTVLDDNKKL CLMSGEIIQL APYTNLIFET MDLEHASPAT VSRCGMIYME PDALGWNLVL
KSWIADTPPV INAWLKNFLY ESLFQRFFCT NISFILVRTS FNVSMLQKIC PMSDTNLVRS
LTYLMDCFLD EYRDVKVAKD IDELDLRAQL EGSFFFSCIW GLGGTLNVKS RERFSVLFRG
FLERNFPLNL VEIFGLPKPI EPPLKPYIFV MPRDGLVFDY RFIKEGKGKW KLWSDELLDA
PPIPRDIPVN QIIVPTIETI RYTALFRLLV ANGKPVLFVG PTGTGKSVYT IDFLLKKNNP
AVNKPLIINF SAQTTANQTQ DTIMEKLDRR RKGVYGAPIG KRWIIFVDDL SMPMKEVYGA
QPPIELLRQW LDHGEWFDRK ERAMIKLIDV HLMCAMAPPY RGGRDVTPRF KRHFVVLTIS
EYEDEVMTMI FSKIVLWHLD TRGFSKEFDP CIDEIVLGTL DIYKESLSNL LPTPAKCHYV
FNLRDFSKVI QGVLLSVPET MPSLVNMRRL WVHEVLRVFG DRLIDQEDIS WLVKQIRLTL
NSRMNVLMEE LFDDLLPSQK EKILDDKSQA IITEQELRNL VYCDFGDTKV DTRLYQEVSN
LEQLREIVET YLAEYNAMSR KPMNLVLFRF AIEHLARISR IIKQPRSHAL LVGVGGTGRQ
SLTRLASHIC DYDVFQIEVT QQYGVHTWHE DMKGILKRAT ATDLHSTFLF SDTQIKHENF
LEDISNMLNS GEIPNIFTAE ELAEICEQMR QIDRQRDRSV QTDGSAVALF NLFVQITRDQ
LHIVIMMSPI GSNFRNRIRK FPALVNCCAI DWLQPWPEDA LLAVATKFLS TIELTDNERT
AGIDMCQFFH VSMQNISAEF VIRLGRYVYV TPISYLEMIN TFKDLLTRKR EEIMMTKIRY
ERGLDQLDET QKQVVTMQEI LKSLQPQLIT ATQDVERMLQ EVDRERQEVA EFEKIVKIDE
SAAEIYANEA AAIKAECDAD LSEAMPILKR AQGALDTLTT ADIAIVRAMK KPPQGVRLIV
ESVCVLKQIK PEKVQQPDGT FVEDYWRAAL RMLSDVKFLD SLLHFDKDNI PDAVIEKIRK
EYLSNPDFNP EKIKKVSTAC EGLCRWVYAM SEYDKVSKVV APKKKALAEA QEIYDEAMNN
LKAKREQLRQ VQERLKMLEN LLEQRKMAFQ AMSDKVADCE IKLKRAEDLI GGLGGEYTRW
SDTAKSLGER YQRLMGDIVI ASGVIAYLAP FTMPFRLRQI ALWIQRCTDL RVICSLDFQL
RDILGDPVLI RSWNIFGLPN DAFSIDNSII IKNARRWPLI IDPQGQANRW IKNMEKQNNV
NIIRLTQPDY GRVLENALQL GLPVLLEHVD EELDAMLEPI LLKETFKQAG VLCIKFGDAI
IEYNSNFRLY ITTRLRNPHY LPEIAVKVTL LNFMITPTGL EDQLLGIVVA KERPDLESEK
NVLIVQGAAN KKLLRETEDK ILEILSVAEG NILEDEEAID ILTSSKNLSD EIQVKQIVAE
QTEKSIDEAR LQYTSIAVYS TILFFTTGID LNLFVNVNYK PFLLWFYIMD SAVLVNIDPM
YQYSLSWFVN LFELTIDHTE PAETVEQRLK DLVKYFTYSL YANICRSLFE KDKLLFSLLL
TINLLKQREQ LSPSHWIFLL TGGIGIDNPH VNPTTWLPIK QWNELCNLDE VQEFSGIREA
FTNNTVEWKR LFDSKEPQTE AIPSPFQHLD LFKKMLILRC IRPDKILPAV QSFVEAELGS
QFIEPPPFDL ASTYADSNCC IPLIFILTAG TDPAQLLLTF ADEQGYSVNR LFSISLGQGQ
GPIAEEIIQT AVIVGNWVVL QNCHLAVSWM STLEKICEGL MPDTIHPEFR LWLTSYPSEH
FPTSVLENSI KMTNEPPKGL RANIVRSYAN DPISDPDFFE SCSQTENFKK LLYSLCFFHA
VIQERRQFGS IGWNVRYEFN ETDLRISVLQ LHVFLDQFED VKFDALKYLT GECNYGGRVT
DNWDRRTLNT ILSKFYSEEL LAKKYYYFDD TSTIYYCPNV REHEAFVEYT KNLPLITEPS
VFGMNENADI IKDQHETNFL FSSLLLTQER IESPTGQFTN DEIVLRMSND ILEKLPDDYD
LVSALKKYPM SYEQSMNTVL IQEMARFNKL LSYIKTSLEN VIRAIKGIVV MSFELEDIYD
AILMNKIPAL WQQYSYPSLK PLGSYVHDLL NRLNFFKEWY EKGAPNIYWI SGFYFTQAFL
TGTRQNYARK YQIPIDLLIF DFFVLDSDTI SVRHPPENGV YIHGLFLDGA RFNKEQMILD
ESLPKVLYEP MLPMWLLPMK KEDIKERVTY ECPVYKTSER RGVLSTTGHS TNFVIAITLP
TLKSQEHWIM RGVALLCQLS E
//
