ID A0A0N0DB55_FUSLA Unreviewed; 2533 AA.
AC A0A0N0DB55;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 09-DEC-2015, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE SubName: Full=Hc-toxin synthetase {ECO:0000313|EMBL:KPA36315.1};
GN ORFNames=FLAG1_10929 {ECO:0000313|EMBL:KPA36315.1};
OS Fusarium langsethiae.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Nectriaceae; Fusarium.
OX NCBI_TaxID=179993 {ECO:0000313|EMBL:KPA36315.1, ECO:0000313|Proteomes:UP000037904};
RN [1] {ECO:0000313|EMBL:KPA36315.1, ECO:0000313|Proteomes:UP000037904}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Fl201059 {ECO:0000313|EMBL:KPA36315.1,
RC ECO:0000313|Proteomes:UP000037904};
RA Lysoe E., Divon H.H., Terzi V., Orru L., Lamontanara A., Kolseth A.-K.,
RA Frandsen R.J., Nielsen K., Thrane U.;
RT "The draft genome sequence of Fusarium langsethiae, a T-2/HT-2 mycotoxin
RT producer.";
RL Submitted (APR-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KPA36315.1}.
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DR EMBL; JXCE01000677; KPA36315.1; -; Genomic_DNA.
DR OrthoDB; 2612884at2759; -.
DR Proteomes; UP000037904; Unassembled WGS sequence.
DR GO; GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
DR GO; GO:0044249; P:cellular biosynthetic process; IEA:UniProt.
DR Gene3D; 3.30.300.30; -; 1.
DR Gene3D; 1.10.1200.10; ACP-like; 2.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 3.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 3.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR001242; Condensatn.
DR InterPro; IPR009081; PP-bd_ACP.
DR PANTHER; PTHR45398; ENZYME, PUTATIVE (JCVI)-RELATED; 1.
DR PANTHER; PTHR45398:SF1; ENZYME, PUTATIVE (JCVI)-RELATED; 1.
DR Pfam; PF00501; AMP-binding; 1.
DR Pfam; PF00668; Condensation; 3.
DR Pfam; PF00550; PP-binding; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR SUPFAM; SSF47336; ACP-like; 2.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 6.
PE 4: Predicted;
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000037904}.
FT DOMAIN 27..87
FT /note="Carrier"
FT /evidence="ECO:0000259|Pfam:PF00550"
FT DOMAIN 300..731
FT /note="Condensation"
FT /evidence="ECO:0000259|Pfam:PF00668"
FT DOMAIN 760..1179
FT /note="Condensation"
FT /evidence="ECO:0000259|Pfam:PF00668"
FT DOMAIN 1207..1531
FT /note="AMP-dependent synthetase/ligase"
FT /evidence="ECO:0000259|Pfam:PF00501"
FT DOMAIN 1873..2251
FT /note="Condensation"
FT /evidence="ECO:0000259|Pfam:PF00668"
FT REGION 1..24
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 96..143
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2474..2533
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 96..114
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 115..141
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2533 AA; 279871 MW; 46C0A74A0185882B CRC64;
MSSQRQSPSR LQVMTNLDSS SQPPQDHLIQ AIASTLSIPL DDILLFDSFS ELGGDQDSAQ
QVCLTCRSKG LDVSGKDILD CPTLAELQTR ITPRGLSLSS CSDSGGTYSS YSSDELSAED
KDNTPQTQGE ERSDGRAAGD DHAVESNLSS LRLSFPTVST GDNESNKSTG LACCYMVLTP
RAGPFDGQSV ALIRIDSVSG FSPSTSPNNN NNNITLSPVE SHLAKSQISL LRMEHGPQIW
IPIDQNYATN DKRALQTWVQ NMDSLTYKEV MKLQIPARRS RVVTRRKSTL SPMNIHELEE
FSLSPMQQLY FQGNNDLIEG TWTKSAILNV QGGAEPADVD AAIDAVVARH SMLRVRFRQT
EEGKWEQCIF PAAPSSYRLT HHVDVAEDEI RALVDDMEVS INPTEGPVFA AMYVHNQERQ
MLYLAAHQLA LDDVSWRIVL SDLDELLQKG TLLSEGSASF KYWTKCQGRQ MAQRLFEPTL
PFEVYSANLE YWALAQESNT FGNSSRLSFN LSPEQACSLE QLSAQVLRTD VSDVFLAALL
LSFCQVFPER NLPTLWKREN GRDGAESEFN ILETVGWFAS LCPIGVSIDS ETDLIQVITL
LKDTRRAIPR FGVPFFTSEF ATSQGAATNI PLEIVFKLVD TAKQLQRQNG LFEPVAAQNQ
IVGLKSTAGP NIGRIALFEI SAALDTSGAQ IDIVYNNTCR YQDKIQTWVQ TFEHHVLDAI
TRLKTHEPQL TLSDIPLLQT SYQSLGRLCS DRRINVKDIE TIYPVTPAQQ EILIAQAQDT
GSYHCHAVYE MAALQLPIDV TRLCEAWEVI VSNTPALRSI FIDAVSREGL FDQAVLRKIS
PSILFIETTD PDEAVATLPA MNTPFGEPRH RLAVCYNPMR MIMRLDASQA ICDLPSLHLL
IAELTRVFSS QNPQDNSSLH NTYLHQISSV DIAYSLEVWK TSLSNAKPCI FPSLSSAANT
TSHTSPFDFD ISRTDIEFFC QQNDIAAEAI FQLAWALVLR AFVGTQEVTF GHQFNARDED
LLCGITSLVG SFATILPCFI DLPASQSLEE CLIFINETFS NAKKHDNIAL AEIQHALGLK
EKTLFNTCLY FHPPDQLDTG DELTATLVTS GRKTDCDVSL TLMFVDEYLR GDLASPCFSP
SQVQSVMRSF HAALYHILTS PEKTIVEADL LTDKDYASLV VQDWEFVQQS QKVSACLHDV
ILQHSLTRPN APAVCSWDGD ITYVQLATLV QRLKTYLVNL GVGPGTVVPV VLEKNHWAPV
IILAVLQAGA SFAPLDSQDP ATAKSTIDYL NPHVVLATET AWKDLNTLAI NLVIINDTFF
AMLTPYVSAI GKDATPDHAA CIFVTPKKSR SIFFTHASLV STFIAQAQPF KLTSESRILQ
LSAFNVDICL VEILGTLVHG GCVCVPHPHD RAHDVAGAMA RMDVTWSYMT SLLARKINPD
SVPSLRTLCF RTRRLDPDTY MPWLEDHDVL VAYGAPDICP LGISVTEVTK DGNLGIISPP
VTGRFWVLNP DNPKKLMPVG AIGELAIDSP LATPHRFALD RPLLAPETCL SADEKPRARY
LKTGHRVRYL DDGTIQFISS VRDEVTVSGS NVDVAQVEQV MRRCLGTGID VVVDSVTTRD
SGPLLAAFLE LGPQVFQQHE SLRDLSPETR EKTYIAKKMF ETALESLPAR DRLPRHCMPS
VFIPVQSFPM STSLKVNRRK LQRMVSDLST HDVLHMSRVP NPGEIQRIVI SQKPLPVTGP
EEAMREHWAS VIGISVSAIK GSSSFFSVGG NKFLAAQLVI TCRKAGLFVS LTDLLGEASL
TEICRSSESS ARKQTKIKTL AAKKLDLKFV KNVIVPQLHC SSPDVLDFAE ASAQQVQGLE
LGMFRTRADI ICLALRFNGP VDPSRLETAC RSLAKMHAIL NVTFVAHEHR MYQVHCASST
PPFMTISCPP GSLDDATQNI IKENQNLSFD PAVPVTKFTF LNGDTQGSLI IRLSKTQIDD
VSAHLLVHDL ASLYDGDSTQ DIPRSSYLDY TRASRVSYQQ GLEYWNCQLD NAKMTKIIAS
TRPTAPASVS EIRTLKQTIS LGQLAPYGMT PDAALKAAWA IVLSTISSTH DVLFGEAIQC
RSPSPDIIGP MSNILPVRVQ FPPSHSTPLD LMNCIQLQRQ SHARHETFGI QELVSQCTPW
RSCTRFSTIV QNYVPGLLDG SSTMNVHGAT FTYRMIESWT KDFPDLFVRS TVQADDRVTL
EIKYSEERLS HSFVQSCLSL LVAAWETITH PDMIHQPMVH SSDEIARSER KIPLPARQSA
PVESLIDSAQ RKELQESILS AWNKVINPSS SIPKNKLPST PFYSISQTIL PAYALASELN
TTFSLNLTAE DILAHPNMNA QLDLIASTLP PKHGSGLTTL LHSKNKPAPD RSATTALRAS
LRSFKNRNSM LSLRTSWIKN KRAPSEASDE TPATILEETP LSPIPTIVIP EIGSSDTPVS
INHHLIELDA GPVHLNPIRS RQQSDDRRSS GGSSRMVIDE VSYTPAPMER SRLSTWGSKF
ELPRRGTSPM TRR
//
