ID A0A0N0HHR1_9ACTN Unreviewed; 723 AA.
AC A0A0N0HHR1;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 09-DEC-2015, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN ORFNames=ADK82_28510 {ECO:0000313|EMBL:KPC78712.1};
OS Streptomyces sp. NRRL S-4.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1519471 {ECO:0000313|EMBL:KPC78712.1, ECO:0000313|Proteomes:UP000037987};
RN [1] {ECO:0000313|Proteomes:UP000037987}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NRRL S-4 {ECO:0000313|Proteomes:UP000037987};
RA Ju K.-S., Doroghazi J.R., Metcalf W.W.;
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KPC78712.1}.
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DR EMBL; LGKJ01000202; KPC78712.1; -; Genomic_DNA.
DR RefSeq; WP_053930917.1; NZ_LGKJ01000202.1.
DR AlphaFoldDB; A0A0N0HHR1; -.
DR STRING; 1519471.ADK82_28510; -.
DR PATRIC; fig|1519471.3.peg.5993; -.
DR Proteomes; UP000037987; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR PANTHER; PTHR11070:SF68; DNA HELICASE; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}.
FT DOMAIN 254..534
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT BINDING 275..282
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 723 AA; 80621 MW; 7CB93DDA8DA259D7 CRC64;
MPRLALSDDF VADLISLQRP VQKEVKDAIQ MFRGLTVPQL HASKGMHLEK LERANDRRIR
TIRITKFYRG VLLAPDDGSE LFTLLRVAPH DEAINWARKR AYSVNGATGG LEVRNVEALE
QMETYFENKA VATPARLFEQ HSDTVLRDLG IDDQVLRLAR VCVTAEDLTV MAPPMMPADQ
YEVLEFLADG YPVQDVWEQL IASRGQTVRT AGDRPAVTLT EAILNSPDRI VEVTGPGELE
RILTEDLAHW RIFLHPAQKR YAYHPGFNGP AQVTGGPGTG KTVVALHRVR HLLRNGRDDD
RILLTTFTNA MASSLRDSLA LLLGESDAHL LGRIDVTTVD ALAARIVRET RGSAPRPLSG
AAERSAWTRA SAREDLPWSE QFLAQEFRNV VLAQGLRTPE EYLRCVRRGR GTQVGRVQRA
RLWRVMERFT TDLSSRDSAT YTQLCDQAAR LLAGSGPRYR HVVVDEAQDL HPAQWRVLRA
CVAERSDDMF LVGDPHQRVY DSRVSLRSLG IHVRGRTSRL RLNYRSTEEI LRWSATLLDG
QPVGRLGEDD DDDAGRDSLH GYRSQLRGRL PAARGYDSQD EELKALTAQI RTWIEEDGVK
PSEVAVCARF NTLVDAVITR LRREGIPAVA VRDDPGRGVS GVRVATMHAM KGLEFRCVAV
AGVTAKVLPF AQQVTPVEVD PVQHQSDLLA EHCLLFVACT RARDALSVSW SGQRSPMLDP
VAG
//
