ID A0A0N0HIW6_9ACTN Unreviewed; 529 AA.
AC A0A0N0HIW6;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 09-DEC-2015, sequence version 1.
DT 24-JAN-2024, entry version 29.
DE RecName: Full=Neutral metalloproteinase {ECO:0000256|RuleBase:RU366073};
DE EC=3.4.24.- {ECO:0000256|RuleBase:RU366073};
GN ORFNames=ADK82_25605 {ECO:0000313|EMBL:KPC79510.1};
OS Streptomyces sp. NRRL S-4.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1519471 {ECO:0000313|EMBL:KPC79510.1, ECO:0000313|Proteomes:UP000037987};
RN [1] {ECO:0000313|Proteomes:UP000037987}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NRRL S-4 {ECO:0000313|Proteomes:UP000037987};
RA Ju K.-S., Doroghazi J.R., Metcalf W.W.;
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Extracellular zinc metalloprotease.
CC {ECO:0000256|RuleBase:RU366073}.
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|RuleBase:RU366073};
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|RuleBase:RU366073}.
CC -!- SIMILARITY: Belongs to the peptidase M4 family.
CC {ECO:0000256|ARBA:ARBA00009388, ECO:0000256|RuleBase:RU366073}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KPC79510.1}.
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DR EMBL; LGKJ01000176; KPC79510.1; -; Genomic_DNA.
DR RefSeq; WP_053930631.1; NZ_LGKJ01000176.1.
DR AlphaFoldDB; A0A0N0HIW6; -.
DR STRING; 1519471.ADK82_25605; -.
DR PATRIC; fig|1519471.3.peg.5374; -.
DR Proteomes; UP000037987; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004222; F:metalloendopeptidase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd09597; M4_TLP; 1.
DR Gene3D; 3.10.170.10; -; 1.
DR Gene3D; 3.10.450.490; -; 1.
DR Gene3D; 1.10.390.10; Neutral Protease Domain 2; 1.
DR InterPro; IPR011096; FTP_domain.
DR InterPro; IPR023612; Peptidase_M4.
DR InterPro; IPR027268; Peptidase_M4/M1_CTD_sf.
DR InterPro; IPR001570; Peptidase_M4_C_domain.
DR InterPro; IPR013856; Peptidase_M4_domain.
DR PANTHER; PTHR33794; BACILLOLYSIN; 1.
DR PANTHER; PTHR33794:SF1; BACILLOLYSIN; 1.
DR Pfam; PF07504; FTP; 1.
DR Pfam; PF01447; Peptidase_M4; 1.
DR Pfam; PF02868; Peptidase_M4_C; 1.
DR PRINTS; PR00730; THERMOLYSIN.
DR SUPFAM; SSF55486; Metalloproteases ('zincins'), catalytic domain; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU366073};
KW Metalloprotease {ECO:0000256|ARBA:ARBA00023049,
KW ECO:0000256|RuleBase:RU366073};
KW Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|RuleBase:RU366073};
KW Secreted {ECO:0000256|RuleBase:RU366073};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|RuleBase:RU366073};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|RuleBase:RU366073}.
FT SIGNAL 1..31
FT /evidence="ECO:0000256|RuleBase:RU366073"
FT CHAIN 32..529
FT /note="Neutral metalloproteinase"
FT /evidence="ECO:0000256|RuleBase:RU366073"
FT /id="PRO_5023158861"
FT DOMAIN 85..130
FT /note="FTP"
FT /evidence="ECO:0000259|Pfam:PF07504"
FT DOMAIN 204..350
FT /note="Peptidase M4"
FT /evidence="ECO:0000259|Pfam:PF01447"
FT DOMAIN 354..528
FT /note="Peptidase M4 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02868"
FT ACT_SITE 344
FT /evidence="ECO:0000256|PIRSR:PIRSR623612-1"
FT ACT_SITE 431
FT /note="Proton donor"
FT /evidence="ECO:0000256|PIRSR:PIRSR623612-1"
SQ SEQUENCE 529 AA; 54458 MW; 4400D8FBD9238A3C CRC64;
MTPHMNTRRA AALAAVAAMV VVGVQSGTAT AGSNTAGADA SSARTTAGAT TLGVNTAGQR
GTAIRAAQAD APTAAESLGL GSQEKLIVRD VIKDAHGTVH TRYERTYAGL PVLGGDLVTH
TAADGKSKGV DKANDARISV PSTQAKVKSA ASARKVVWAG GGKPVLAFES VRTGVRKDGT
PSRLHIITDA TTGKKLHSFE AVETGTGNSQ YSGEVTLSTT KGSSGFELAD GDRGGHRTYD
LNQGQTGTGD LVTDADDTWG DGTGGDRQTA AVDAHYGAAK TWDFYKSELG RDGIGGDGKA
AYSRVHFGTG YVNAFWDDSC FCMTYGDGAD DKSALTAIDV AGHEMTHGLT AATANLDYAG
ESGGLNEATS DILGSSVEFF ADNTTDAGDY LIGEKIDING DGTPLRYMDK PSKDGGSADY
WDSGVGDLDV HYSSGVANHF FYLLAEGSGA KTIGGVDYDS PTADGSTVTG IGRQKAYQIW
YKALSVYMTS STDYAGARVA TEKAATDLFG ADSAELAAVD AAWTGVNVK
//