ID   A0A0N0IBX4_9GAMM        Unreviewed;       859 AA.
AC   A0A0N0IBX4;
DT   09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT   09-DEC-2015, sequence version 1.
DT   24-JAN-2024, entry version 23.
DE   RecName: Full=Adenylate cyclase {ECO:0000256|ARBA:ARBA00021420, ECO:0000256|RuleBase:RU000604};
DE            EC=4.6.1.1 {ECO:0000256|ARBA:ARBA00012201, ECO:0000256|RuleBase:RU000604};
GN   ORFNames=M992_0415 {ECO:0000313|EMBL:KPD04302.1};
OS   Moellerella wisconsensis ATCC 35017.
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC   Morganellaceae; Moellerella.
OX   NCBI_TaxID=1354267 {ECO:0000313|EMBL:KPD04302.1, ECO:0000313|Proteomes:UP000053226};
RN   [1] {ECO:0000313|EMBL:KPD04302.1, ECO:0000313|Proteomes:UP000053226}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 35017 {ECO:0000313|EMBL:KPD04302.1,
RC   ECO:0000313|Proteomes:UP000053226};
RA   Plunkett G.III., Neeno-Eckwall E.C., Glasner J.D., Perna N.T.;
RT   "ATOL: Assembling a taxonomically balanced genome-scale reconstruction of
RT   the evolutionary history of the Enterobacteriaceae.";
RL   Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP = 3',5'-cyclic AMP + diphosphate; Xref=Rhea:RHEA:15389,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:58165; EC=4.6.1.1;
CC         Evidence={ECO:0000256|ARBA:ARBA00001593,
CC         ECO:0000256|RuleBase:RU000604};
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496,
CC       ECO:0000256|RuleBase:RU000604}.
CC   -!- SIMILARITY: Belongs to the adenylyl cyclase class-1 family.
CC       {ECO:0000256|ARBA:ARBA00007901, ECO:0000256|RuleBase:RU004184}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KPD04302.1}.
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DR   EMBL; LGAA01000003; KPD04302.1; -; Genomic_DNA.
DR   RefSeq; WP_053907137.1; NZ_LGAA01000003.1.
DR   AlphaFoldDB; A0A0N0IBX4; -.
DR   OrthoDB; 5571448at2; -.
DR   Proteomes; UP000053226; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0004016; F:adenylate cyclase activity; IEA:UniProtKB-EC.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0006171; P:cAMP biosynthetic process; IEA:UniProtKB-KW.
DR   InterPro; IPR000274; Adenylate_cyclase_1.
DR   InterPro; IPR024686; Adenylate_cyclase_1_CS.
DR   InterPro; IPR024685; Adenylate_cyclase_1_N.
DR   PANTHER; PTHR38760; ADENYLATE CYCLASE; 1.
DR   PANTHER; PTHR38760:SF1; ADENYLATE CYCLASE; 1.
DR   Pfam; PF12633; Adenyl_cycl_N; 1.
DR   Pfam; PF01295; Adenylate_cycl; 1.
DR   PIRSF; PIRSF001444; Adenylate_cycl; 1.
DR   PROSITE; PS01092; ADENYLATE_CYCLASE_1_1; 1.
DR   PROSITE; PS01093; ADENYLATE_CYCLASE_1_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   cAMP biosynthesis {ECO:0000256|ARBA:ARBA00022998,
KW   ECO:0000256|RuleBase:RU000604}; Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000256|RuleBase:RU000604};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Reference proteome {ECO:0000313|Proteomes:UP000053226}.
FT   DOMAIN          5..201
FT                   /note="Adenylate cyclase class-I N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF12633"
SQ   SEQUENCE   859 AA;  98930 MW;  756B34D2D7D99E8B CRC64;
     MYLYIETLKQ RLDAINQLRL ERATSSMSEA FQQVYSLLPV LFHYHHPMLP GYIEGHVPHG
     VCYFSPDAHQ LGWLNQFEKY LPCEVIHQTE SGELPLTGIY SMGSTSSIGQ SICSDLDIWV
     CHPSWLDNEE KQRLQQKCSL IEQWAASLGI EVTLFLIDEN RFRHHASGHL GGEDCGSTQH
     ILLLDEFYRT AVRMAGKRLL WTMVPVEEEN NYDEYVMSLY AQGVLAPNEW LDLGGLGELS
     AEEYFGASLW QLYKSVDSPY KAVLKSILLE SYSWDYPTGK LLALEFKQHL HAGEIVCYGL
     DSYCLMLDRV TRYLTEIHDF TRLDLIRRCF YLKVCEKLSK ETQNACSGWR RHILSQLVES
     WGWDKERLNI LDERHQWKIE RVREAHNELL DTMMQSYRNL IRFARRNNLS VSASPQDIGV
     LTRKLYAAFE ALPGKVTLVN PQISPDLSEN HLTFIYVPPG RANRSGWYLY NQAPGIETII
     GHQPLEYNRY LNKLVAWAYF NGLLTESSTV YMHHGQSQCD KQKLLELIDD VSSHFPIRLP
     APTPKALYSP CEIRHLAIIV NLEQDPTQEF SNQVVHFDFR KLDIFSFGDP QQCLIGSIDL
     LYRNSWNEVR TLHFSGEQSM LEALKTILGK MHQDASPPDS VEVFCYSQHL RGLIRTRVQQ
     LISECVELRL SSNRHDPGRF KPLRIAGQMW GLFFERLNVS VQKLENAVEF YGAISHNKLH
     GLPIKLNAKE THHLPAVVDG YASEGIVQFF FENTDDGKGF NIYVLDEANR VEIYSHCEGS
     KEELVRDVSR FYSSSHDRFT YGANFINFNL PQFYQIIKNN GHNQVIPFAG GAWALVTEQV
     NSDDGRLNKH YSDVCSMHN
//