ID A0A0N0K725_9CAUL Unreviewed; 1080 AA.
AC A0A0N0K725;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 09-DEC-2015, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=site-specific DNA-methyltransferase (adenine-specific) {ECO:0000256|ARBA:ARBA00011900};
DE EC=2.1.1.72 {ECO:0000256|ARBA:ARBA00011900};
GN ORFNames=IP78_03375 {ECO:0000313|EMBL:KPF82915.1};
OS Brevundimonas sp. AAP58.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Caulobacterales;
OC Caulobacteraceae; Brevundimonas.
OX NCBI_TaxID=1523422 {ECO:0000313|EMBL:KPF82915.1, ECO:0000313|Proteomes:UP000037838};
RN [1] {ECO:0000313|EMBL:KPF82915.1, ECO:0000313|Proteomes:UP000037838}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AAP58 {ECO:0000313|EMBL:KPF82915.1,
RC ECO:0000313|Proteomes:UP000037838};
RA Zeng Y., Feng F., Liu Y., Koblizek M.;
RT "Novel Diversity of Limnic Aerobic Anoxygenic Phototrophic Bacteria as
RT Revealed by High-throughput Strain Identification and Genome Sequencing.";
RL Submitted (AUG-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an
CC N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-
CC homocysteine; Xref=Rhea:RHEA:15197, Rhea:RHEA-COMP:12418, Rhea:RHEA-
CC COMP:12419, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:90615, ChEBI:CHEBI:90616; EC=2.1.1.72;
CC Evidence={ECO:0000256|ARBA:ARBA00001279};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KPF82915.1}.
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DR EMBL; LJHU01000019; KPF82915.1; -; Genomic_DNA.
DR RefSeq; WP_054110306.1; NZ_LJHU01000019.1.
DR AlphaFoldDB; A0A0N0K725; -.
DR STRING; 1523422.IP78_03375; -.
DR PATRIC; fig|1523422.3.peg.962; -.
DR OrthoDB; 5194627at2; -.
DR Proteomes; UP000037838; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0008170; F:N-methyltransferase activity; IEA:InterPro.
DR GO; GO:0006306; P:DNA methylation; IEA:InterPro.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR003356; DNA_methylase_A-5.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR041635; Type_ISP_LLaBIII_C.
DR PANTHER; PTHR33841; DNA METHYLTRANSFERASE YEEA-RELATED; 1.
DR PANTHER; PTHR33841:SF5; TYPE II METHYLTRANSFERASE M.HINDII; 1.
DR Pfam; PF02384; N6_Mtase; 1.
DR Pfam; PF18135; Type_ISP_C; 1.
DR PRINTS; PR00507; N12N6MTFRASE.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
PE 4: Predicted;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Reference proteome {ECO:0000313|Proteomes:UP000037838};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 333..442
FT /note="DNA methylase adenine-specific"
FT /evidence="ECO:0000259|Pfam:PF02384"
FT DOMAIN 720..1017
FT /note="Type ISP restriction-modification enzyme LLaBIII C-
FT terminal specificity"
FT /evidence="ECO:0000259|Pfam:PF18135"
SQ SEQUENCE 1080 AA; 118356 MW; F72FC57A902B95E6 CRC64;
MPTDDSRALL KAYAKSIRDS RRAHPNVTEP GLAPLFQALV EKLLPHLPAA PHDLIVLAEF
INAGVGRPDL ALKRPGEEAR SFIELKALDK PTSGARWTTP HDRRQFIRFS ELPNWAVSNF
HGFRLYARGE DQGQATLVPE EALDPNRDDA AADKLIDAHD PTAALNLLER LVQADPPQAK
DAEHLAELLA HSAKLVRGIV RDRLAELAAD GVTGTPLHQV RQEFRDVLYS HPEAGGYSAA
DFDDLFSSAF AQTLAFGLLL VREATGGKPV DKDAYEQMPD EHPLMKTALR VLSLKEVAAD
VGIGFQVMLQ TVNGFDPNIL AIRKDGSDPI LYFYEFFLET FDPAARERYG VYYTPVEVVR
FMVGALDRAL KQDLKTKGIA DPTVHILDPA TGTGTFLLGI ADRLRREVSE TDGPGQAPAA
LRGLASRMYG FELLIGPYAV AHYRLHHTLA RDKDGKVDPT FRLPRLGVYL TDTLAEPNAA
APAGALGFVS EGIQDERAES NRIKTQQPIL AIIGNPPYRR LEVGENESLV GRWMDGVWDD
LKKPVRDAGW GNQLNTFPEL SVAFWRWAMW KLFEADNAPK KGVIAFISNR KYLTGKPYAG
LRKMLRERFD RIEVYDLRGD GRAGARAGVE GDGNVFNILT GVAITVAIAD GSKAEGELAR
VDYVDAWEQG RTSRNSKLAW MLEGEPEGAL PGAVEVDRGL LDDMRPVPFL NGELLSISEC
FGLNSSGVES KRDHVVYDFS ESLLMTRLAE VLSHEGERLD FAFNSTTMNP ASVAKQQGVQ
QALVQDAAYR PLDVRSHYTS RAWNDRLRPT LQAAWGNNNI ALFALPSGTK AGPAVWCHGL
IPDRHAFRGS YGGYAFPLYD RRPGHGPHNL KPELVTALAD AYGSEVTPEA VFDAILALLS
ATSYTTRFAE DLEDVFPHIP FPADRAVFDA AAAVGAEIRA IQTFARPPGA GYTKGLALAQ
TAPSGKLRPI DPRDLDGVKL TLCEDGSGEI FPLPREVWDF AVSGYRLVPR WLAAREGLDA
TAPDFIPQLR DLVGRVAELI DLNLRADSLL AQTLDDPLSR DSLGFASADA AAETATPDDE
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