ID   A0A0N0NEG5_9ACTN        Unreviewed;       342 AA.
AC   A0A0N0NEG5;
DT   09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT   09-DEC-2015, sequence version 1.
DT   27-MAR-2024, entry version 25.
DE   SubName: Full=Adenosine deaminase {ECO:0000313|EMBL:KPI31151.1};
DE            EC=3.5.4.4 {ECO:0000313|EMBL:KPI31151.1};
GN   ORFNames=OV320_2878 {ECO:0000313|EMBL:KPI31151.1};
OS   Actinobacteria bacterium OV320.
OC   Bacteria; Actinomycetota; Actinomycetes.
OX   NCBI_TaxID=1592329 {ECO:0000313|EMBL:KPI31151.1, ECO:0000313|Proteomes:UP000037870};
RN   [1] {ECO:0000313|EMBL:KPI31151.1, ECO:0000313|Proteomes:UP000037870}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=OV320 {ECO:0000313|EMBL:KPI31151.1,
RC   ECO:0000313|Proteomes:UP000037870};
RA   Brown S.D., Utturkar S.M., Klingeman D.M., Pelletier D.;
RT   "Draft genome sequences for four actinobacteria strains OK006 OK074 OV450
RT   and OV320.";
RL   Submitted (AUG-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|ARBA:ARBA00001947};
CC   -!- SIMILARITY: Belongs to the metallo-dependent hydrolases superfamily.
CC       Adenosine and AMP deaminases family. {ECO:0000256|ARBA:ARBA00006676}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KPI31151.1}.
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DR   EMBL; LJCX01000019; KPI31151.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0N0NEG5; -.
DR   PATRIC; fig|1592329.3.peg.1710; -.
DR   Proteomes; UP000037870; Unassembled WGS sequence.
DR   GO; GO:0046936; F:2'-deoxyadenosine deaminase activity; IEA:UniProtKB-EC.
DR   GO; GO:0004000; F:adenosine deaminase activity; IEA:UniProtKB-EC.
DR   GO; GO:0009168; P:purine ribonucleoside monophosphate biosynthetic process; IEA:InterPro.
DR   Gene3D; 3.20.20.140; Metal-dependent hydrolases; 1.
DR   InterPro; IPR006650; A/AMP_deam_AS.
DR   InterPro; IPR001365; A_deaminase_dom.
DR   InterPro; IPR006330; Ado/ade_deaminase.
DR   InterPro; IPR032466; Metal_Hydrolase.
DR   NCBIfam; TIGR01430; aden_deam; 1.
DR   PANTHER; PTHR43114; ADENINE DEAMINASE; 1.
DR   PANTHER; PTHR43114:SF6; ADENINE DEAMINASE; 1.
DR   Pfam; PF00962; A_deaminase; 1.
DR   SUPFAM; SSF51556; Metallo-dependent hydrolases; 1.
DR   PROSITE; PS00485; A_DEAMINASE; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000313|EMBL:KPI31151.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000037870}.
FT   DOMAIN          11..340
FT                   /note="Adenosine deaminase"
FT                   /evidence="ECO:0000259|Pfam:PF00962"
SQ   SEQUENCE   342 AA;  37482 MW;  80B39C1B297B3D6C CRC64;
     MERVRDVSEL PKAHLHLHFT GSMRATTVLE LADKYGVHLP DALNEALTSG EPPKLRATDE
     RGWFRFQRLY DAARSCVREP EDIQRLVREA AEEDLKDGSG WLEIQVDPTS YAPRLGGLIP
     ALEIILDAVE TASRDTGLGM RVLVAANRMK HPLDARTLAR LAVRYADRGV VGFGLSNDER
     RGMARDFDRA FAIAREGGLL SAPHGGELTG PSSVRDCLDD LDANRLGHGV RAAEDPRLLK
     RLADRGVTCE VCPASNVALG VYEKPEDVPL RTLFEAGVPM ALGADDPLLF GSRLAAQYDI
     ARRHHAFTDE ELAELARQSV RASAAPEDIR AKLLAGVDDW LA
//