ID A0A0N0NFT4_9ACTN Unreviewed; 413 AA.
AC A0A0N0NFT4;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 09-DEC-2015, sequence version 1.
DT 24-JAN-2024, entry version 20.
DE SubName: Full=6-deoxyerythronolide-B synthase {ECO:0000313|EMBL:KPI32289.1};
DE EC=2.3.1.94 {ECO:0000313|EMBL:KPI32289.1};
GN ORFNames=OV320_2465 {ECO:0000313|EMBL:KPI32289.1};
OS Actinobacteria bacterium OV320.
OC Bacteria; Actinomycetota; Actinomycetes.
OX NCBI_TaxID=1592329 {ECO:0000313|EMBL:KPI32289.1, ECO:0000313|Proteomes:UP000037870};
RN [1] {ECO:0000313|EMBL:KPI32289.1, ECO:0000313|Proteomes:UP000037870}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=OV320 {ECO:0000313|EMBL:KPI32289.1,
RC ECO:0000313|Proteomes:UP000037870};
RA Brown S.D., Utturkar S.M., Klingeman D.M., Pelletier D.;
RT "Draft genome sequences for four actinobacteria strains OK006 OK074 OV450
RT and OV320.";
RL Submitted (AUG-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP
CC synthases family. {ECO:0000256|RuleBase:RU003694}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KPI32289.1}.
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DR EMBL; LJCX01000005; KPI32289.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0N0NFT4; -.
DR PATRIC; fig|1592329.3.peg.1052; -.
DR Proteomes; UP000037870; Unassembled WGS sequence.
DR GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR GO; GO:0047879; F:erythronolide synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR CDD; cd00833; PKS; 1.
DR Gene3D; 3.40.47.10; -; 1.
DR InterPro; IPR018201; Ketoacyl_synth_AS.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR43775:SF37; FATTY ACID SYNTHASE; 1.
DR Pfam; PF00109; ketoacyl-synt; 1.
DR Pfam; PF02801; Ketoacyl-synt_C; 1.
DR SMART; SM00825; PKS_KS; 1.
DR SUPFAM; SSF53901; Thiolase-like; 1.
DR PROSITE; PS00606; KS3_1; 1.
DR PROSITE; PS52004; KS3_2; 1.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000313|EMBL:KPI32289.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000037870};
KW Transferase {ECO:0000256|RuleBase:RU003694, ECO:0000313|EMBL:KPI32289.1}.
FT DOMAIN 8..409
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
SQ SEQUENCE 413 AA; 43541 MW; 7185C90B3EB77EDE CRC64;
MSELAKHSAP VAVIGVGGRF ARAPDVGAFW DNLVAGRDCF RREPVPVVED LGEDRLRVHS
WGTAPHRDTY DHALVGVEGL DPQHGILQES LWQAAEDAGV RLSAIADRTA VYAGCARTKH
VPRAAFDDVV QVDPTFAGPY FSYLQDLWGE SLMLDSACAT STVAVQLACQ SLRSHACDYA
LAGAVAIQED ADGSYLRTPR SIYSTEGIVR PFDRRHNGVV PGDGSGAVLL RRLDDALRDG
DPVYAVIRGG AVTNDGRAKP GFVIPGVDGK VRAVRRALEA AGLTGADVDY VETHGVGIPL
NDQIEATALI EALGTEGPPV AVGSVKASVG HCDTAAGMAA LIKTCLAIDR GFLPATPNTE
VPIEEFTGRG ERFGILPEGR PWPTNGRPRT AGLMSAGVGG TNAFLVLEEA PAH
//