ID   A0A0N0NFT4_9ACTN        Unreviewed;       413 AA.
AC   A0A0N0NFT4;
DT   09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT   09-DEC-2015, sequence version 1.
DT   24-JAN-2024, entry version 20.
DE   SubName: Full=6-deoxyerythronolide-B synthase {ECO:0000313|EMBL:KPI32289.1};
DE            EC=2.3.1.94 {ECO:0000313|EMBL:KPI32289.1};
GN   ORFNames=OV320_2465 {ECO:0000313|EMBL:KPI32289.1};
OS   Actinobacteria bacterium OV320.
OC   Bacteria; Actinomycetota; Actinomycetes.
OX   NCBI_TaxID=1592329 {ECO:0000313|EMBL:KPI32289.1, ECO:0000313|Proteomes:UP000037870};
RN   [1] {ECO:0000313|EMBL:KPI32289.1, ECO:0000313|Proteomes:UP000037870}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=OV320 {ECO:0000313|EMBL:KPI32289.1,
RC   ECO:0000313|Proteomes:UP000037870};
RA   Brown S.D., Utturkar S.M., Klingeman D.M., Pelletier D.;
RT   "Draft genome sequences for four actinobacteria strains OK006 OK074 OV450
RT   and OV320.";
RL   Submitted (AUG-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP
CC       synthases family. {ECO:0000256|RuleBase:RU003694}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KPI32289.1}.
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DR   EMBL; LJCX01000005; KPI32289.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0N0NFT4; -.
DR   PATRIC; fig|1592329.3.peg.1052; -.
DR   Proteomes; UP000037870; Unassembled WGS sequence.
DR   GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR   GO; GO:0047879; F:erythronolide synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR   CDD; cd00833; PKS; 1.
DR   Gene3D; 3.40.47.10; -; 1.
DR   InterPro; IPR018201; Ketoacyl_synth_AS.
DR   InterPro; IPR014031; Ketoacyl_synth_C.
DR   InterPro; IPR014030; Ketoacyl_synth_N.
DR   InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR   InterPro; IPR016039; Thiolase-like.
DR   PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR   PANTHER; PTHR43775:SF37; FATTY ACID SYNTHASE; 1.
DR   Pfam; PF00109; ketoacyl-synt; 1.
DR   Pfam; PF02801; Ketoacyl-synt_C; 1.
DR   SMART; SM00825; PKS_KS; 1.
DR   SUPFAM; SSF53901; Thiolase-like; 1.
DR   PROSITE; PS00606; KS3_1; 1.
DR   PROSITE; PS52004; KS3_2; 1.
PE   3: Inferred from homology;
KW   Acyltransferase {ECO:0000313|EMBL:KPI32289.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000037870};
KW   Transferase {ECO:0000256|RuleBase:RU003694, ECO:0000313|EMBL:KPI32289.1}.
FT   DOMAIN          8..409
FT                   /note="Ketosynthase family 3 (KS3)"
FT                   /evidence="ECO:0000259|PROSITE:PS52004"
SQ   SEQUENCE   413 AA;  43541 MW;  7185C90B3EB77EDE CRC64;
     MSELAKHSAP VAVIGVGGRF ARAPDVGAFW DNLVAGRDCF RREPVPVVED LGEDRLRVHS
     WGTAPHRDTY DHALVGVEGL DPQHGILQES LWQAAEDAGV RLSAIADRTA VYAGCARTKH
     VPRAAFDDVV QVDPTFAGPY FSYLQDLWGE SLMLDSACAT STVAVQLACQ SLRSHACDYA
     LAGAVAIQED ADGSYLRTPR SIYSTEGIVR PFDRRHNGVV PGDGSGAVLL RRLDDALRDG
     DPVYAVIRGG AVTNDGRAKP GFVIPGVDGK VRAVRRALEA AGLTGADVDY VETHGVGIPL
     NDQIEATALI EALGTEGPPV AVGSVKASVG HCDTAAGMAA LIKTCLAIDR GFLPATPNTE
     VPIEEFTGRG ERFGILPEGR PWPTNGRPRT AGLMSAGVGG TNAFLVLEEA PAH
//