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Database: UniProt
Entry: A0A0N0P622_LEPSE
LinkDB: A0A0N0P622_LEPSE
Original site: A0A0N0P622_LEPSE 
ID   A0A0N0P622_LEPSE        Unreviewed;       775 AA.
AC   A0A0N0P622;
DT   09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT   09-DEC-2015, sequence version 1.
DT   03-MAY-2023, entry version 25.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
GN   ORFNames=ABL78_3779 {ECO:0000313|EMBL:KPI87126.1};
OS   Leptomonas seymouri.
OC   Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC   Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leptomonas.
OX   NCBI_TaxID=5684 {ECO:0000313|EMBL:KPI87126.1, ECO:0000313|Proteomes:UP000038009};
RN   [1] {ECO:0000313|EMBL:KPI87126.1, ECO:0000313|Proteomes:UP000038009}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 30220 {ECO:0000313|EMBL:KPI87126.1,
RC   ECO:0000313|Proteomes:UP000038009};
RX   PubMed=26317207;
RA   Kraeva N., Butenko A., Hlavacova J., Kostygov A., Myskova J., Grybchuk D.,
RA   Lestinova T., Votypka J., Volf P., Opperdoes F., Flegontov P., Lukes J.,
RA   Yurchenko V.;
RT   "Leptomonas seymouri: Adaptations to the Dixenous Life Cycle Analyzed by
RT   Genome Sequencing, Transcriptome Profiling and Co-infection with Leishmania
RT   donovani.";
RL   PLoS Pathog. 11:E1005127-E1005127(2015).
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-ATPase), a
CC       multimeric enzyme that catalyzes the translocation of protons across
CC       the membranes. Required for assembly and activity of the V-ATPase.
CC       {ECO:0000256|RuleBase:RU361189}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|ARBA:ARBA00009904, ECO:0000256|RuleBase:RU361189}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KPI87126.1}.
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DR   EMBL; LJSK01000101; KPI87126.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0N0P622; -.
DR   EnsemblProtists; KPI87126; KPI87126; ABL78_3779.
DR   VEuPathDB; TriTrypDB:Lsey_0101_0100; -.
DR   OMA; WCPTNDL; -.
DR   OrthoDB; 1967517at2759; -.
DR   Proteomes; UP000038009; Unassembled WGS sequence.
DR   GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0046961; F:proton-transporting ATPase activity, rotational mechanism; IEA:InterPro.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR   PANTHER; PTHR11629:SF63; V-TYPE PROTON ATPASE SUBUNIT A; 1.
DR   PANTHER; PTHR11629; VACUOLAR PROTON ATPASES; 1.
DR   Pfam; PF01496; V_ATPase_I; 2.
DR   PIRSF; PIRSF001293; ATP6V0A1; 2.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Hydrogen ion transport {ECO:0000256|ARBA:ARBA00022781,
KW   ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW   ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361189};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM        376..400
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   TRANSMEM        412..436
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   TRANSMEM        511..531
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   TRANSMEM        538..562
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   TRANSMEM        600..624
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   TRANSMEM        682..707
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   TRANSMEM        713..733
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   COILED          56..136
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   775 AA;  87547 MW;  3D5F2C5DF8E275CE CRC64;
     MPQEACSGLW RSEDMVVLSL HMQREVAHDA VLKLGEIGMF QFLDLNKELS AFQRDFVQEV
     RRCDDMERKL RFLQEEIDKA GVATIVEGGA EGETMSSLEQ KIDEVYSEVL ELNEQYQALI
     EERNRSKEHL EILLRDFGGA SGDGLMMVTG VIPKDRIPLF ERLVYRATRG NSIMCTDDIE
     TPFYNINANE PVYKSVFAIY FSAPRLRERL VKIAEANAAT VYQYADTEQR LNNMHASLQQ
     QVDTITQTLH QSAYRQRQVL LGIAASCYEW RRAVVTEKAV FSTMNMLKFS GSTAVAQGWA
     PVRACDDIRT AVAEAEYLSG AQVGTIIEEL HTKEAPPTYF KTNKITSSFQ GIVDSYGMAR
     YKEANPGVFT IISFPYLFGV MYGDVGHGLI LTLFAAFLVF KEKSFEGQPL NEIFAMIFGG
     RYLLLLMGFF AVYMGLLYND MFGFSIEIFT SAYRWPQLPP EGPDGVVYPS FPNGRPSVKP
     TSPVAFGVDS AWSETENKLE FYNSIKMKCS VIIGVAQMMA GVFISLTNYL YFNDWVKVWF
     RFVPEIAFLS FTFGYMCLLI IVKWLTTWES THDAPSLLET MTNFFLSPGT VTSQLYSGQA
     AVQVVLLLLC ALCVPIMLCV IPYMEKKEHD HKMQERAAHP PADGEEEEED DFEFSEIIIH
     QIIHTIEYVL GCVSNTASYL RLWALSLAHS QLSEVFWSFA FLLTVGLDGG SGVFVFVGFA
     VWMAATIGVL LGMESLSAFL HALRLHWVEF NNKFYIADGY PFEPFDLAES LSKIH
//
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