ID   A0A0N0P942_LEPSE        Unreviewed;       869 AA.
AC   A0A0N0P942;
DT   09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT   09-DEC-2015, sequence version 1.
DT   27-MAR-2024, entry version 35.
DE   SubName: Full=Putative Atp-dependent DEAD/H RNA helicase {ECO:0000313|EMBL:KPI90669.1};
GN   ORFNames=ABL78_0265 {ECO:0000313|EMBL:KPI90669.1};
OS   Leptomonas seymouri.
OC   Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC   Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leptomonas.
OX   NCBI_TaxID=5684 {ECO:0000313|EMBL:KPI90669.1, ECO:0000313|Proteomes:UP000038009};
RN   [1] {ECO:0000313|EMBL:KPI90669.1, ECO:0000313|Proteomes:UP000038009}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 30220 {ECO:0000313|EMBL:KPI90669.1,
RC   ECO:0000313|Proteomes:UP000038009};
RX   PubMed=26317207;
RA   Kraeva N., Butenko A., Hlavacova J., Kostygov A., Myskova J., Grybchuk D.,
RA   Lestinova T., Votypka J., Volf P., Opperdoes F., Flegontov P., Lukes J.,
RA   Yurchenko V.;
RT   "Leptomonas seymouri: Adaptations to the Dixenous Life Cycle Analyzed by
RT   Genome Sequencing, Transcriptome Profiling and Co-infection with Leishmania
RT   donovani.";
RL   PLoS Pathog. 11:E1005127-E1005127(2015).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KPI90669.1}.
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DR   EMBL; LJSK01000003; KPI90669.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0N0P942; -.
DR   EnsemblProtists; KPI90669; KPI90669; ABL78_0265.
DR   VEuPathDB; TriTrypDB:Lsey_0003_0620; -.
DR   OMA; FAQYVHT; -.
DR   OrthoDB; 161140at2759; -.
DR   Proteomes; UP000038009; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   CDD; cd18787; SF2_C_DEAD; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR   InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR000629; RNA-helicase_DEAD-box_CS.
DR   PANTHER; PTHR47959:SF13; ATP-DEPENDENT RNA HELICASE RHLE; 1.
DR   PANTHER; PTHR47959; ATP-DEPENDENT RNA HELICASE RHLE-RELATED; 1.
DR   Pfam; PF00270; DEAD; 1.
DR   Pfam; PF00271; Helicase_C; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR   PROSITE; PS00039; DEAD_ATP_HELICASE; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000313|EMBL:KPI90669.1};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741}.
FT   DOMAIN          261..439
FT                   /note="Helicase ATP-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS51192"
FT   DOMAIN          475..628
FT                   /note="Helicase C-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS51194"
FT   REGION          1..30
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          87..115
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   869 AA;  94618 MW;  FF1C6B79AAAE6046 CRC64;
     MPKRVRNDGG GAKVAEASRD APIVNAAGAL EPLSENDEDF AGALGPLGGD SLLSCATPTS
     SSDNDSDNED ASMRLLLYAK ASAATKAQPN PSAAASVDTP ASFLRGSGGS NGTTKATSSA
     VTALRAFNAE LLKPVAESTA LTVVNAEDES ADVLAKIVSR KVPPPTPGDS KKLRQLTYVN
     HSEMQYIPIR KDFYVVPPDM KDLTPVEMRA LLRELDGAKV QGQDLPRPLR SWHATGLPDK
     VLEVLERHEY RNPFAVQSLG APALMSGRDL LVTAKTGSGK TLCYALPIIR HCADQPRCEK
     GEGPIGLVLV PTQELAVQVF TLLKELGDVC GLRCIASYGN TSLSDNIRQA KAGCEMMVAT
     PGRLLDLLTV NGGKTMTLSR VSFVVVDEAD RLFDSGFMEH VTAFLRNVRP DRVIGMISAT
     MPKELRHSVM QHLHKPVIIS VGGKPTPASN VEQQFLFFDE EVYDASKIKT EMPQRLVRLL
     ALLGEEGGDG QNLILVFTQR KEEVDELVGQ LTTLGYANRV ASLYSGMDPI DREFALEHFA
     PGKQFILIAT AVAERGLDIP YLGLVINYRL PNHYEAYVHR IGRTGRAGRS GRAVSFFTRG
     KDDDIAPELV EGLERAEQHI PEELYEISEK VRTLRKSGEA RYNSSFFRGY RDAKAQRFTD
     RNQKQQMREA ARAAGYEEFL SSTSSENDSD VESDENADIT AVPVQSKAQM AAEEVEVKNA
     VALTLHRSAA AGALTLSAAQ EDRIAKALKF AEKTTAAATL SADDTAAVRF QSEYPVNDLP
     DVVRGKLQSS SFMKAVGEET ETSLVRKGVY FDPRYKHSRR MKEGERPLYL LIVGKSMEAV
     RAARNKLDER KAELLSKQTK TGSVTGASL
//