ID   A0A0N0SG10_9ACTN        Unreviewed;       525 AA.
AC   A0A0N0SG10;
DT   09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT   09-DEC-2015, sequence version 1.
DT   24-JAN-2024, entry version 25.
DE   SubName: Full=Purine permease {ECO:0000313|EMBL:KOU42554.1};
GN   ORFNames=ADK55_24800 {ECO:0000313|EMBL:KOU42554.1};
OS   Streptomyces sp. WM4235.
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=1415551 {ECO:0000313|EMBL:KOU42554.1, ECO:0000313|Proteomes:UP000037699};
RN   [1] {ECO:0000313|EMBL:KOU42554.1, ECO:0000313|Proteomes:UP000037699}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=WM4235 {ECO:0000313|EMBL:KOU42554.1,
RC   ECO:0000313|Proteomes:UP000037699};
RA   Noorani M.;
RL   Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC
CC       2.A.40) family. {ECO:0000256|ARBA:ARBA00008821}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KOU42554.1}.
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DR   EMBL; LGDE01000424; KOU42554.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0N0SG10; -.
DR   PATRIC; fig|1415551.3.peg.5404; -.
DR   Proteomes; UP000037699; Unassembled WGS sequence.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProt.
DR   GO; GO:0015205; F:nucleobase transmembrane transporter activity; IEA:UniProt.
DR   InterPro; IPR006043; NCS2.
DR   InterPro; IPR017588; UacT-like.
DR   InterPro; IPR006042; Xan_ur_permease.
DR   NCBIfam; TIGR00801; ncs2; 1.
DR   NCBIfam; NF037981; NCS2_1; 1.
DR   NCBIfam; TIGR03173; pbuX; 1.
DR   PANTHER; PTHR42810; PURINE PERMEASE C1399.01C-RELATED; 1.
DR   PANTHER; PTHR42810:SF4; URIC ACID TRANSPORTER UACT; 1.
DR   Pfam; PF00860; Xan_ur_permease; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000037699};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT   TRANSMEM        36..54
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        60..78
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        90..110
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        116..137
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        149..170
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        190..207
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        214..237
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        257..274
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        337..360
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        366..386
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        398..417
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        429..447
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   REGION          482..525
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        488..511
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   525 AA;  53372 MW;  D107D943067B40A2 CRC64;
     MARVAARLSV NGEQSSHPVD EVLPLPKLAL YGFQHVLAFY AGAVIVPILV GSALKLSPEQ
     LVYLINADLF TCGIASIIQA WGIGRIGARL PIIQGVTFTA VSPMIAIGLG AGGGTAALLV
     IYGAVITAGI ATFAFAWMPA RVFRVVMSLF PPVVTGTVIT ILGIVLLPVA LKDVVGGAPL
     VGDGGDPKQL AYAVGTMLFV LVMMRLGRPF VSSIAVLLGL VGGTLVAFAL GDAKFAAVGQ
     SDWIGVTTPF HFGAPKFEWF PILLMLIVML ITMVETTGDT YAVGEIVGKD IDSETVARAL
     RADGAATAIG GLLNSFPYVA FAENVGLVRV TKVKSRFVVV AAGVIMIILG LLPKAAAVVA
     AIPPGVLGGA ATVMFGMVAL AGIQTLGKVD LKEEKNALIV GVALAFALFP ATVPAFFEKH
     MSVDLASLLN SGVTLGATAA ILMNLLFNGL GKGDPHADPQ AAPAAAPEVV LPAQADAPVA
     LAAAHKADGS DGSDESNATD GSDKADKAAV RDPAGTTDGA ATPAG
//