ID A0A0N0SGN0_9ACTN Unreviewed; 3646 AA.
AC A0A0N0SGN0;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 09-DEC-2015, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE SubName: Full=Peptide synthetase {ECO:0000313|EMBL:KOU47302.1};
GN ORFNames=ADK56_25800 {ECO:0000313|EMBL:KOU47302.1};
OS Streptomyces sp. MMG1522.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1415545 {ECO:0000313|EMBL:KOU47302.1, ECO:0000313|Proteomes:UP000037713};
RN [1] {ECO:0000313|EMBL:KOU47302.1, ECO:0000313|Proteomes:UP000037713}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MMG1522 {ECO:0000313|EMBL:KOU47302.1,
RC ECO:0000313|Proteomes:UP000037713};
RA Noorani M.;
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC Evidence={ECO:0000256|ARBA:ARBA00001957};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KOU47302.1}.
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DR EMBL; LGDF01000147; KOU47302.1; -; Genomic_DNA.
DR RefSeq; WP_053607664.1; NZ_LGDF01000147.1.
DR PATRIC; fig|1415545.3.peg.5533; -.
DR Proteomes; UP000037713; Unassembled WGS sequence.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0043604; P:amide biosynthetic process; IEA:UniProt.
DR GO; GO:0017000; P:antibiotic biosynthetic process; IEA:UniProt.
DR GO; GO:0008610; P:lipid biosynthetic process; IEA:UniProt.
DR GO; GO:1901362; P:organic cyclic compound biosynthetic process; IEA:UniProt.
DR GO; GO:1901566; P:organonitrogen compound biosynthetic process; IEA:UniProt.
DR CDD; cd05930; A_NRPS; 1.
DR CDD; cd17646; A_NRPS_AB3403-like; 1.
DR CDD; cd17643; A_NRPS_Cytc1-like; 1.
DR Gene3D; 3.30.300.30; -; 3.
DR Gene3D; 3.40.50.980; -; 2.
DR Gene3D; 1.10.1200.10; ACP-like; 2.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 4.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 2.
DR Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 4.
DR InterPro; IPR010071; AA_adenyl_domain.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR001242; Condensatn.
DR InterPro; IPR010060; NRPS_synth.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR NCBIfam; TIGR01733; AA-adenyl-dom; 3.
DR NCBIfam; TIGR01720; NRPS-para261; 1.
DR PANTHER; PTHR45527:SF1; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR45527; NONRIBOSOMAL PEPTIDE SYNTHETASE; 1.
DR Pfam; PF00501; AMP-binding; 3.
DR Pfam; PF13193; AMP-binding_C; 3.
DR Pfam; PF00668; Condensation; 4.
DR Pfam; PF00550; PP-binding; 3.
DR SMART; SM00823; PKS_PP; 3.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 3.
DR SUPFAM; SSF47336; ACP-like; 3.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 8.
DR PROSITE; PS00455; AMP_BINDING; 2.
DR PROSITE; PS50075; CARRIER; 3.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 2.
PE 4: Predicted;
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553}.
FT DOMAIN 644..718
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 2147..2221
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 3569..3646
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT REGION 2221..2240
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3646 AA; 389225 MW; 8A2CEF3D29B05AC9 CRC64;
MAEPSPSGIQ LSPTRLAALR RRTGDHGDRT LVQACAAGLA YWASGTGRED LGLTPATPFP
ELLDRIREGA ATAGAWRIDE RTLGITVPPG IDPAAAQRAL DDLADFPHRP LGTIGPSGPR
ERAAELARWN DTRADRARPT VMELFREQAR LRPDAVAVVD GRRSLTYRET AESSAQLAHH
LVERGLAPEQ VVGISLGRSA EMVVGLLAVL QAGGAFVPLD PQWPAARRAS VAEDARIALQ
LNATGKADRG EPDAVAVDLG DWKYGAHPAD APEATPSGDA LAYVIFTSGS TGRPKGAMIR
HEAISERLLW QSREILGFGP DDASLFKAPL SFDISVNEIL LPLVSGGRLV VLRPGGERDP
HHLLAVIAEH RVTFTYLVSS MLDVLLEIVG DTGRLDSLRH VWCGGEVLTP ELYERFRDRL
GIPLYHGYGP AETTIGVSHV IYRGAAERLT TSIGRANPNT QLHVLDDELR PVPVGVGGEL
YVGGLLLGRG YANAPGLTAS RFVANPFASD GSRLYRTGDL ARYAPDGSLD FLGRADNQVK
IRGMRLEIED VEAGLAEHPG VRRTCVVAKK NAAGGTHLVG YVIPSGDHRD LSADEVTAWA
ADHLVEYMVP AHVVVLTEFP LTANGKVDRK ALPEPSVGAG AVVAPATENE RLVCEAVASV
LRLDAVGADQ DFFRLGGDSI LAISLLGALR DAGLHVTARQ IFTHTVVGAL AAVASRESAA
VDHEDVPTGD VEGSPVVRWL GGTTDAIDGF VQSVVLTTPA ELTAEALDAL LDAVLTRHDM
LRAKLVRGEH WSFDIPGAAT APRCWEESDA PLAQCVARAT ETLDPDNGVM LRAVWGRAAR
RLVLVAHHLV IDGVSWRVLM DDLATAWHRY SAGESVEPPP AGTSFRRWTQ LLARTPFDAD
RAYWTAPLPA ADEPLGRRAL TEADTVERER TRTVTVGPET TAALLGEIPA KFHAGVNDVL
LTALAVALAR WRRDRGQDQT FAHIELEGHG REGRFVADAA GFEPDLSRTV GWFTTLFPVT
VDPGGAPDLT GPGYLAAALK AVKEDLARVP ANGLSYGALR HLGGGLPAGP APQVLFNYLG
RFAAAATGDW QHASSVGQLG ERRDPRMRLP RPLEFNAVAE PGANGSHELV TTVSWPDGVF
TEDDITVLCD HFRTTLTALA ALDGGGHTPS DFPLVEVVQA DVDALDGPAL LDVLPLTPLQ
EGLYFHSVFD DEATGAYVEQ QLIGLEGEVD AERLEAAATR LLALHPALAA RFTALDDGRV
VSVVESGRRP RFTVLDRPGI TGEDLRDLAE QDRRAGFDLA AGPLMRFTLV RTGDGRATLV
QTVHHIIADG WSVEPMLRTL LAEYHAPGSA HPLGGYRDYV AWLAGRDQDE SDRVWGEELA
GLFGPSLVAE GHTPSGRFAD VAADFTDDVE AAARAAGTSL SVAVHSAWAV TLGAVLGSSD
VVLGSTVSGR DAEVPGIRDM VGLFINTVPV RVRWSATDTA ADLLDAVRLH QGAVRAHQHV
SLARIGRLSG AGALFDTLVV FDIAADVSAL RGPDDTLVIT DLVNEGAPHY PLTLVVERAP
EGRSRFNLIY DAELLRHERA EAILHSFTRA LADLLGRPDD RVGALVRAPG RAPAADRPTT
LGELFDAAAR RDPAATAVTQ CGPDGAASSL TYGELAAAKT TLATALRAAG VRPGRRVAVA
VPRSVEQVVA LVAAVTAGGA YVPLDLAYPD ERLEYVLADA APQVVLVDRE HRDRFARLLD
RAGVAARILV QGDEPPLAEG PEGGRPATDV PAVRPGDPAY VIYTSGSTGR PKGVLVPHSA
VTTLLANTRA DMEFGPDDVW VQFHSFSFDF AVWELWGALA HGSELLVPDY GLTRSPVDFH
RLVRERGVTV LNQTPSAFHR FMEADLHAER PVTTLRRIVF GGEALDPVRL RGWVERHGTT
APELVNMYGI TETTVHVTHR VLTDEDFARG GDASPIGGPI PGLSVHVLDD RLRPVPPGRV
GAVHVAGGQL ALGYLGRPGL TAGRFVADPF AADGSRMYHT GDLARRTVDG ELEFVGRADD
QVQLNGFRIE PGEVENAVRE VDGVVDAAVT VAGSGDHLVL HVVGEPPADL TERLAARLPA
HMVPALVLPA DALPLTVNGK LDRKALTERA ARAARQEAPP RPIAPGATDD SAVTALTGVF
AEALPRASVD ADTDFFGAGG DSIVAITVIN RARALGLPIA PRDVFLHRTP RALAAHLAAD
AVQPASARPG RREDGPLPPT PIILRQRELG APLAGFAQAR AVPVAEGAGL ADIRRAADAV
VAAHPALRLR LTVEHGVWSL RTEPPHAAEV AVPEHTADAT AAAAEAARRL DPEAGEVVAF
SWLTASRTLV VTVHHLAVDA VSWLILLDDL ATALGGAPLP PPTTSYAAHA EALAVRAAEG
SDNIGHWITA LRAPDLLPAV AGHREATVVL PPETSDLVTR TAPGALGIGL TELLCGALRA
ALTRVQTTPT DLAVELERHG RVPAAEHHDY SRTVGWFTSI APVRLTAHTD PVAAARETAA
RRPDEDGHTA YGRLRYLNPQ TAPLLTARPQ VLFNYLGRGN ESEALRITGN TPATSPYAVE
VNAWTDEATG RLHAAFTLAD GVPDAITGHW LTALEQIADA SATAERTAPV TPLQRGLYFQ
SQLAATAGHY VAQSFFTFDR TLDTDALSEA MARVISRHPV VGAGFTTDDD GDPVQLLKAG
RRVAVRTVHL STRAEAEALR TEDRERGFDP GEPPLVRMTV VRGLEGGDRL LLSYHLLLWD
GWSREILLRD LFDAYEAVVA GRAWDASPAV PGFEEYARTL AAKDPAVSTR FWAEHLAGLP
GPTLLAGPAP ALGDELPRPL THTLPAELSH LLRETARTRG VTLNSVLTGA FGLLLGARTG
RGDAVFGVTV SGREGDGHGD IVGVLLNTVP MWTRARPDDT VDAYLSSVQA ARVAAMEHEH
LGLGEIQRAG GHDTLFDNLF VLQNFLDLDA LAEMNARHGI TSVLADDSTH YPYTWVVTPG
DRLTVKLEHR HGDAAHARRL LDDYVRVLSD LATATGPLGA LPGLGPDPAP AVRTPIGTDT
VVDRFDLAAD RHPGRTALVA AGTTMTFGEL RDRSRSVAGV LAARGIGPES TVGLAIPRSA
DWIAALFAVL RVGAAYVPLE LDHPDERIAS ITADARPEAT LTVSAVAPRL SGELIELDRP
LPPAEPYTTF APDDPDRLRH PAYTIYTSGS TGKPKGVVTE YAGLTNMLIN HQRRVFEPVL
AEHGHRTFRI AHTVSFAFDM SWEELLWLAD GHEVHICDEE LRRDAPRLVD YCLRHGIDVV
NVTPTYAQQL VAEGLLDDPE RRPALVLLGG EAVTPTLWQR LAATEGTVGY NLYGPTEYTI
NTLGVGTFEC QDPVVGVAID NTEVYVLDPW LRPLPDGVPG ELYVSGVGIA RGYLGRSAQT
AHRFVACPFG TPGERMYRTG DLVTRRPDGN IAYLGRTDQQ VKIRGHRVEL GEVEAVFAAH
PAVRHAAAIA QPDPGVDGAH RLAAYLVLAD PADLAQVAAE AGAGLPDFLR PTHYARVDSI
PLTVNGKADT KALPEARPLG ALTTAGERGP ETETESVVCE FFAEALDLDD NEVSAVSDFV
SLGGHSMLAV RLIGLLRREY GPVVTVRDLF TLRTPEALAR HLDENC
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