ID A0A0N0SHR0_9ACTN Unreviewed; 720 AA.
AC A0A0N0SHR0;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 09-DEC-2015, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE SubName: Full=3-hydroxyacyl-CoA dehydrogenase {ECO:0000313|EMBL:KOU51288.1};
GN ORFNames=ADK56_10570 {ECO:0000313|EMBL:KOU51288.1};
OS Streptomyces sp. MMG1522.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1415545 {ECO:0000313|EMBL:KOU51288.1, ECO:0000313|Proteomes:UP000037713};
RN [1] {ECO:0000313|EMBL:KOU51288.1, ECO:0000313|Proteomes:UP000037713}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MMG1522 {ECO:0000313|EMBL:KOU51288.1,
RC ECO:0000313|Proteomes:UP000037713};
RA Noorani M.;
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + H(+) +
CC NADH; Xref=Rhea:RHEA:22432, ChEBI:CHEBI:15378, ChEBI:CHEBI:57318,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:90726; EC=1.1.1.35;
CC Evidence={ECO:0000256|ARBA:ARBA00023693};
CC -!- PATHWAY: Lipid metabolism; fatty acid beta-oxidation.
CC {ECO:0000256|ARBA:ARBA00005005}.
CC -!- SIMILARITY: In the central section; belongs to the 3-hydroxyacyl-CoA
CC dehydrogenase family. {ECO:0000256|ARBA:ARBA00007005}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KOU51288.1}.
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DR EMBL; LGDF01000105; KOU51288.1; -; Genomic_DNA.
DR RefSeq; WP_053606818.1; NZ_LGDF01000105.1.
DR AlphaFoldDB; A0A0N0SHR0; -.
DR PATRIC; fig|1415545.3.peg.2276; -.
DR UniPathway; UPA00659; -.
DR Proteomes; UP000037713; Unassembled WGS sequence.
DR GO; GO:0003857; F:3-hydroxyacyl-CoA dehydrogenase activity; IEA:UniProtKB-EC.
DR GO; GO:0016829; F:lyase activity; IEA:UniProtKB-KW.
DR GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR GO; GO:0006635; P:fatty acid beta-oxidation; IEA:UniProtKB-UniPathway.
DR CDD; cd06558; crotonase-like; 1.
DR Gene3D; 1.10.1040.50; -; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR InterPro; IPR006108; 3HC_DH_C.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR InterPro; IPR001753; Enoyl-CoA_hydra/iso.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR43612; TRIFUNCTIONAL ENZYME SUBUNIT ALPHA; 1.
DR PANTHER; PTHR43612:SF3; TRIFUNCTIONAL ENZYME SUBUNIT ALPHA, MITOCHONDRIAL; 1.
DR Pfam; PF00725; 3HCDH; 1.
DR Pfam; PF02737; 3HCDH_N; 1.
DR Pfam; PF00378; ECH_1; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 2.
DR SUPFAM; SSF52096; ClpP/crotonase; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW Fatty acid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW Lipid degradation {ECO:0000256|ARBA:ARBA00022963};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW Lyase {ECO:0000256|ARBA:ARBA00023239};
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW NAD {ECO:0000256|ARBA:ARBA00023027}.
FT DOMAIN 321..499
FT /note="3-hydroxyacyl-CoA dehydrogenase NAD binding"
FT /evidence="ECO:0000259|Pfam:PF02737"
FT DOMAIN 502..601
FT /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00725"
SQ SEQUENCE 720 AA; 77595 MW; 39C199F6EDB07023 CRC64;
MPASAITLTR DADGIVTLLL DDPSSSVNTM NDAFMTGLEE TVPRLEAERE DITGVLLRSA
KRTFFAGGDL NRLSSGSADR AAEETAYIDR MKDFMRRLER LGRPVVALLE GTALGGGLEV
ALCAHHRIAT DAPDSRFGLP EVGLGLIPGG GGITRTVRML GLRSALSEVI LPARRFAPRD
ALAAGLVDEV VADAAEAETR AREWIAAHPD AVQPWDVKGF RLPGGDVRDP AIAAVLPALS
GLLRKRTKGA PMPAPRAALA AAVEGAHVDF DTASRVETRY LVSLIISQVT KNMIKAFFFD
LRSITSGASR PQGYERFAAR KAGVVGAGMM GAGIAYVSAR AGIDVVLRDV TREAAEKGKD
YARGLEEEAV AAGRRTREEA DALLGRITTT DEAADFTGVD LVIEAVFESA PLKQRVFQEV
QDIVRPDAVL GSNTSTLPIS QLARGVKRES DVIGIHFFSP VDRMRLVEIV RGVQTSDETL
AKVFDFVLQI GRTPIVVNDS RGFFTSRVIG RFIAEAVAAV GEGVEPATVE QAALQAGYPA
GALQLLDELT LSLTQRIRVE TRAAEEAEGR TWVAHPSEDV VDWMLEQGRV GRRERAGWYD
YDDSGKRLGI WPGVRDRYGS GRRTLPLRDL QERMLFAEAL DSIDCLESGV LTSVADANVG
SIQGIGFPAW TGGVLQYVNQ YEGGLPGFVA RARELAAAYG DRFLPPTSLV ERAERGEIYA
//
