ID   A0A0N1A920_9PROT        Unreviewed;       364 AA.
AC   A0A0N1A920;
DT   09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT   09-DEC-2015, sequence version 1.
DT   24-JAN-2024, entry version 25.
DE   SubName: Full=4-hydroxyphenylpyruvate dioxygenase {ECO:0000313|EMBL:KPF43259.1};
GN   ORFNames=D621_20050 {ECO:0000313|EMBL:KPF43259.1};
OS   beta proteobacterium AAP51.
OC   Bacteria; Pseudomonadota; Betaproteobacteria.
OX   NCBI_TaxID=1523421 {ECO:0000313|EMBL:KPF43259.1, ECO:0000313|Proteomes:UP000037990};
RN   [1] {ECO:0000313|EMBL:KPF43259.1, ECO:0000313|Proteomes:UP000037990}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AAP51 {ECO:0000313|EMBL:KPF43259.1,
RC   ECO:0000313|Proteomes:UP000037990};
RA   Zeng Y., Feng F., Liu Y., Koblizek M.;
RT   "Novel Diversity of Limnic Aerobic Anoxygenic Phototrophic Bacteria as
RT   Revealed by High-throughput Strain Identification and Genome Sequencing.";
RL   Submitted (AUG-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=Fe cation; Xref=ChEBI:CHEBI:24875;
CC         Evidence={ECO:0000256|PIRSR:PIRSR009283-1};
CC       Note=Binds 1 Fe cation per subunit. {ECO:0000256|PIRSR:PIRSR009283-1};
CC   -!- SIMILARITY: Belongs to the 4HPPD family.
CC       {ECO:0000256|ARBA:ARBA00005877}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KPF43259.1}.
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DR   EMBL; LJHT01000105; KPF43259.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0N1A920; -.
DR   PATRIC; fig|1523421.3.peg.232; -.
DR   OrthoDB; 9780241at2; -.
DR   Proteomes; UP000037990; Unassembled WGS sequence.
DR   GO; GO:0003868; F:4-hydroxyphenylpyruvate dioxygenase activity; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0009072; P:aromatic amino acid metabolic process; IEA:InterPro.
DR   CDD; cd07250; HPPD_C_like; 1.
DR   CDD; cd08342; HPPD_N_like; 1.
DR   Gene3D; 3.10.180.10; 2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1; 2.
DR   InterPro; IPR005956; 4OHPhenylPyrv_dOase.
DR   InterPro; IPR041735; 4OHPhenylPyrv_dOase_C.
DR   InterPro; IPR041736; 4OHPhenylPyrv_dOase_N.
DR   InterPro; IPR029068; Glyas_Bleomycin-R_OHBP_Dase.
DR   InterPro; IPR004360; Glyas_Fos-R_dOase_dom.
DR   InterPro; IPR037523; VOC.
DR   NCBIfam; TIGR01263; 4HPPD; 1.
DR   PANTHER; PTHR11959; 4-HYDROXYPHENYLPYRUVATE DIOXYGENASE; 1.
DR   PANTHER; PTHR11959:SF1; 4-HYDROXYPHENYLPYRUVATE DIOXYGENASE; 1.
DR   Pfam; PF00903; Glyoxalase; 1.
DR   Pfam; PF14696; Glyoxalase_5; 1.
DR   PIRSF; PIRSF009283; HPP_dOase; 1.
DR   SUPFAM; SSF54593; Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase; 1.
DR   PROSITE; PS51819; VOC; 2.
PE   3: Inferred from homology;
KW   Dioxygenase {ECO:0000313|EMBL:KPF43259.1};
KW   Iron {ECO:0000256|ARBA:ARBA00023004, ECO:0000256|PIRSR:PIRSR009283-1};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW   ECO:0000256|PIRSR:PIRSR009283-1};
KW   Oxidoreductase {ECO:0000313|EMBL:KPF43259.1};
KW   Pyruvate {ECO:0000313|EMBL:KPF43259.1};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT   DOMAIN          14..131
FT                   /note="VOC"
FT                   /evidence="ECO:0000259|PROSITE:PS51819"
FT   DOMAIN          173..323
FT                   /note="VOC"
FT                   /evidence="ECO:0000259|PROSITE:PS51819"
FT   BINDING         176
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR009283-1"
FT   BINDING         255
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR009283-1"
FT   BINDING         332
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR009283-1"
SQ   SEQUENCE   364 AA;  40558 MW;  DD2D50BBD275F3E0 CRC64;
     MSFTPWDNPM GTDGFEFIEY AAPDPVAMGA LFERMGFRAI AKHRHKNVLL YRQGEINFIV
     NAEPDSFAQR FARLHGPSIC AIAFRVQNAR QAFARAQELG AWAYAGSAGP GELNIPAIKG
     IGDSLIYLVD KWRGKNGAKD GDIGNIGFFD VDFEPLPGVG TDALNPKGHG LTYIDHLTHN
     VHRGRMAEWA DFYERLFNFR EVRYFDIEGQ VTGVKSKAMT SPCGKIRIPI NEEGNEKAGQ
     IQEYLDKYHG EGIQHIALGS DELLATVDAM RASGVKLLET IDTYYELVDK RIPGHGQDVA
     ALQQRKVLID GKAGELLLQI FSENQLGPIF FEFIQRKGDQ GFGEGNFKAL FESIELDQMR
     RGVL
//