ID A0A0N1ARP8_9PROT Unreviewed; 509 AA.
AC A0A0N1ARP8;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 09-DEC-2015, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Deoxyribodipyrimidine photolyase {ECO:0000313|EMBL:KPF57373.1};
GN ORFNames=D621_08150 {ECO:0000313|EMBL:KPF57373.1};
OS beta proteobacterium AAP51.
OC Bacteria; Pseudomonadota; Betaproteobacteria.
OX NCBI_TaxID=1523421 {ECO:0000313|EMBL:KPF57373.1, ECO:0000313|Proteomes:UP000037990};
RN [1] {ECO:0000313|EMBL:KPF57373.1, ECO:0000313|Proteomes:UP000037990}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AAP51 {ECO:0000313|EMBL:KPF57373.1,
RC ECO:0000313|Proteomes:UP000037990};
RA Zeng Y., Feng F., Liu Y., Koblizek M.;
RT "Novel Diversity of Limnic Aerobic Anoxygenic Phototrophic Bacteria as
RT Revealed by High-throughput Strain Identification and Genome Sequencing.";
RL Submitted (AUG-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate;
CC Xref=ChEBI:CHEBI:15636; Evidence={ECO:0000256|ARBA:ARBA00001932};
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|PIRSR:PIRSR602081-1};
CC Note=Binds 1 FAD per subunit. {ECO:0000256|PIRSR:PIRSR602081-1};
CC -!- SIMILARITY: Belongs to the DNA photolyase family.
CC {ECO:0000256|RuleBase:RU004182}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KPF57373.1}.
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DR EMBL; LJHT01000027; KPF57373.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0N1ARP8; -.
DR PATRIC; fig|1523421.3.peg.1756; -.
DR Proteomes; UP000037990; Unassembled WGS sequence.
DR GO; GO:0016829; F:lyase activity; IEA:UniProtKB-KW.
DR GO; GO:0097159; F:organic cyclic compound binding; IEA:UniProt.
DR GO; GO:0051716; P:cellular response to stimulus; IEA:UniProt.
DR GO; GO:0006139; P:nucleobase-containing compound metabolic process; IEA:UniProt.
DR GO; GO:0006950; P:response to stress; IEA:UniProt.
DR Gene3D; 1.25.40.80; -; 1.
DR Gene3D; 1.10.579.10; DNA Cyclobutane Dipyrimidine Photolyase, subunit A, domain 3; 1.
DR Gene3D; 3.40.50.620; HUPs; 1.
DR InterPro; IPR036134; Crypto/Photolyase_FAD-like_sf.
DR InterPro; IPR036155; Crypto/Photolyase_N_sf.
DR InterPro; IPR005101; Cryptochr/Photolyase_FAD-bd.
DR InterPro; IPR002081; Cryptochrome/DNA_photolyase_1.
DR InterPro; IPR018394; DNA_photolyase_1_CS_C.
DR InterPro; IPR006050; DNA_photolyase_N.
DR InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR PANTHER; PTHR11455; CRYPTOCHROME; 1.
DR PANTHER; PTHR11455:SF9; CRYPTOCHROME-1; 1.
DR Pfam; PF00875; DNA_photolyase; 1.
DR Pfam; PF03441; FAD_binding_7; 1.
DR PRINTS; PR00147; DNAPHOTLYASE.
DR SUPFAM; SSF48173; Cryptochrome/photolyase FAD-binding domain; 1.
DR SUPFAM; SSF52425; Cryptochrome/photolyase, N-terminal domain; 1.
DR PROSITE; PS00691; DNA_PHOTOLYASES_1_2; 1.
DR PROSITE; PS51645; PHR_CRY_ALPHA_BETA; 1.
PE 3: Inferred from homology;
KW Chromophore {ECO:0000256|ARBA:ARBA00022991, ECO:0000256|RuleBase:RU004182};
KW FAD {ECO:0000256|ARBA:ARBA00022827, ECO:0000256|PIRSR:PIRSR602081-1};
KW Flavoprotein {ECO:0000256|ARBA:ARBA00022630, ECO:0000256|PIRSR:PIRSR602081-
KW 1}; Lyase {ECO:0000313|EMBL:KPF57373.1}.
FT DOMAIN 14..150
FT /note="Photolyase/cryptochrome alpha/beta"
FT /evidence="ECO:0000259|PROSITE:PS51645"
FT BINDING 244
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000256|PIRSR:PIRSR602081-1"
FT BINDING 299
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000256|PIRSR:PIRSR602081-1"
FT BINDING 302..309
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000256|PIRSR:PIRSR602081-1"
FT BINDING 402..404
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000256|PIRSR:PIRSR602081-1"
FT SITE 333
FT /note="Electron transfer via tryptophanyl radical"
FT /evidence="ECO:0000256|PIRSR:PIRSR602081-2"
FT SITE 389
FT /note="Electron transfer via tryptophanyl radical"
FT /evidence="ECO:0000256|PIRSR:PIRSR602081-2"
FT SITE 412
FT /note="Electron transfer via tryptophanyl radical"
FT /evidence="ECO:0000256|PIRSR:PIRSR602081-2"
SQ SEQUENCE 509 AA; 57057 MW; 1B1662AC372666A8 CRC64;
MKKTQHPHPA PKIDRALVWL RRDLRVDDHA ALHHALKAAR QVWCVFVFDR DILDPLPRQD
RRVEFIRDSL VGVDAELRAL AASHGVEGAG LIVMHGWPVQ AIPALAARLQ VQAVYASHDD
EPAAETRDAQ VRGRLADAGV MLHTMKDHVV FERSEVLTLS GGAFSVFTPY KNAWLKKCEP
YFLSAWPVAK HAGALAPRPA GEPGVPALED IGFARTNLHQ LRLPSGPAGA QELLADFLER
MDRYGETRDF PAIKGPSYLS THLRFGTVSV RQLARLAMER RNASPPAPPD GPRSGAEVWL
SELIWRDFYH QVLHHHPRVV TGAFKPEYDR IRWEHGKHAD ELFAAWCEGR TGYPLVDAAM
HQLAQTGYMH NRLRMVVASF LAKDLGLDWR RGEAWFALHL NDFDLAANNG GWQWAASSGC
DAQPYFRIFN PVSQSEKFDP QGRFIRRYLP QLAALPDKLI HAPWQARPVD LLAANIELGK
HYPRPVVDHA EAREKTLARY AVVKAGAAG
//
