ID A0A0N1BMX8_9CAUL Unreviewed; 507 AA.
AC A0A0N1BMX8;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 09-DEC-2015, sequence version 1.
DT 24-JAN-2024, entry version 21.
DE SubName: Full=Tryptophan halogenase {ECO:0000313|EMBL:KPF77904.1};
GN ORFNames=IP78_11720 {ECO:0000313|EMBL:KPF77904.1};
OS Brevundimonas sp. AAP58.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Caulobacterales;
OC Caulobacteraceae; Brevundimonas.
OX NCBI_TaxID=1523422 {ECO:0000313|EMBL:KPF77904.1, ECO:0000313|Proteomes:UP000037838};
RN [1] {ECO:0000313|EMBL:KPF77904.1, ECO:0000313|Proteomes:UP000037838}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AAP58 {ECO:0000313|EMBL:KPF77904.1,
RC ECO:0000313|Proteomes:UP000037838};
RA Zeng Y., Feng F., Liu Y., Koblizek M.;
RT "Novel Diversity of Limnic Aerobic Anoxygenic Phototrophic Bacteria as
RT Revealed by High-throughput Strain Identification and Genome Sequencing.";
RL Submitted (AUG-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KPF77904.1}.
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DR EMBL; LJHU01000091; KPF77904.1; -; Genomic_DNA.
DR RefSeq; WP_054111860.1; NZ_LJHU01000091.1.
DR AlphaFoldDB; A0A0N1BMX8; -.
DR STRING; 1523422.IP78_11720; -.
DR PATRIC; fig|1523422.3.peg.2881; -.
DR OrthoDB; 5695497at2; -.
DR Proteomes; UP000037838; Unassembled WGS sequence.
DR GO; GO:0004497; F:monooxygenase activity; IEA:InterPro.
DR GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR006905; Flavin_halogenase.
DR InterPro; IPR033856; Trp_halogen.
DR PANTHER; PTHR43747; FAD-BINDING PROTEIN; 1.
DR PANTHER; PTHR43747:SF4; FLAVIN-DEPENDENT TRYPTOPHAN HALOGENASE; 1.
DR Pfam; PF04820; Trp_halogenase; 1.
DR PIRSF; PIRSF011396; Trp_halogenase; 1.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
PE 4: Predicted;
KW FAD {ECO:0000256|PIRSR:PIRSR011396-2};
KW Flavoprotein {ECO:0000256|PIRSR:PIRSR011396-2};
KW Nucleotide-binding {ECO:0000256|PIRSR:PIRSR011396-2};
KW Reference proteome {ECO:0000313|Proteomes:UP000037838}.
FT ACT_SITE 78
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-1"
FT BINDING 13..16
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-2"
FT BINDING 78
FT /ligand="7-chloro-L-tryptophan"
FT /ligand_id="ChEBI:CHEBI:58713"
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-2"
FT BINDING 333
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-2"
FT BINDING 342
FT /ligand="L-tryptophan"
FT /ligand_id="ChEBI:CHEBI:57912"
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-2"
FT BINDING 346
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-2"
SQ SEQUENCE 507 AA; 56531 MW; A257A98BB8627372 CRC64;
MAEPIQSILI VGGGTAGWMA AAAIKRSVGP NAEVRLVESA DIGIVGVGEA TVPPIRDFNA
MIDLDEAEFM RETKATIKLG IEFNGWGRAD SAYFHPFGTF GRGPTLGEFP GSYFALKARG
KAASLEAYSV TSHAARRGKV GERSNDPRSA LAGFHTAYHF DAVLYGQYLR KVCAGRGIER
IEGEIVEVLQ RPEDGFVDHV VLKDGRTLKA DLFIDCTGFR GLLIEQTLKA GYEDWSHWLP
MNRALAVPCA KVRAVDPFTS STAREAGWQW RIALQHRTGN GYVYCSDYID DDRARETLLA
NLDGEALAEP RPLRFVTGRR KKLWDRNVVA LGLSSGFIEP LESTSIHLVQ VGIIRLLQHW
PDMAFSQPNI DGYNRRLTRE IELIRDFVIL HYHATQRDDT PFWRHVSQMP VPDSLSERVE
MFRDRGLLFQ VGADEYFSQG SWMAVMMGQG ITPRAYNPLY DYQNLDQVAA GFEQTRQAWA
ATANALPAHE DYLKAKGMWA EEKAAAA
//
