ID A0A0N1G4R8_9ACTN Unreviewed; 539 AA.
AC A0A0N1G4R8;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 09-DEC-2015, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE SubName: Full=NADH dehydrogenase (Quinone) {ECO:0000313|EMBL:KPI11366.1};
DE EC=1.6.5.11 {ECO:0000313|EMBL:KPI11366.1};
GN ORFNames=OK006_4246 {ECO:0000313|EMBL:KPI11366.1};
OS Actinobacteria bacterium OK006.
OC Bacteria; Actinomycetota; Actinomycetes.
OX NCBI_TaxID=1592326 {ECO:0000313|EMBL:KPI11366.1, ECO:0000313|Proteomes:UP000037912};
RN [1] {ECO:0000313|EMBL:KPI11366.1, ECO:0000313|Proteomes:UP000037912}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=OK006 {ECO:0000313|EMBL:KPI11366.1,
RC ECO:0000313|Proteomes:UP000037912};
RA Brown S.D., Utturkar S.M., Klingeman D.M., Pelletier D.;
RT "Draft genome sequences for four Actinobacteria strains OK006 OK074 OV450
RT and OV320.";
RL Submitted (SEP-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=FMN; Xref=ChEBI:CHEBI:58210;
CC Evidence={ECO:0000256|ARBA:ARBA00001917};
CC -!- COFACTOR:
CC Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC Evidence={ECO:0000256|ARBA:ARBA00001966};
CC -!- SIMILARITY: Belongs to the complex I 51 kDa subunit family.
CC {ECO:0000256|ARBA:ARBA00007523}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KPI11366.1}.
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DR EMBL; LJCU01000165; KPI11366.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0N1G4R8; -.
DR PATRIC; fig|1592326.3.peg.5260; -.
DR Proteomes; UP000037912; Unassembled WGS sequence.
DR GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0050136; F:NADH dehydrogenase (quinone) activity; IEA:UniProtKB-EC.
DR Gene3D; 3.10.20.600; -; 1.
DR Gene3D; 3.30.70.20; -; 1.
DR Gene3D; 3.40.50.11540; NADH-ubiquinone oxidoreductase 51kDa subunit; 1.
DR Gene3D; 1.20.1440.230; NADH-ubiquinone oxidoreductase 51kDa subunit, iron-sulphur binding domain; 1.
DR InterPro; IPR011538; Nuo51_FMN-bd.
DR InterPro; IPR037225; Nuo51_FMN-bd_sf.
DR InterPro; IPR019575; Nuop51_4Fe4S-bd.
DR InterPro; IPR037207; Nuop51_4Fe4S-bd_sf.
DR InterPro; IPR019554; Soluble_ligand-bd.
DR PANTHER; PTHR11780:SF10; NADH DEHYDROGENASE [UBIQUINONE] FLAVOPROTEIN 1, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11780; NADH-UBIQUINONE OXIDOREDUCTASE FLAVOPROTEIN 1 NDUFV1; 1.
DR Pfam; PF01512; Complex1_51K; 1.
DR Pfam; PF13459; Fer4_15; 1.
DR Pfam; PF10589; NADH_4Fe-4S; 1.
DR Pfam; PF10531; SLBB; 1.
DR SMART; SM00928; NADH_4Fe-4S; 1.
DR SUPFAM; SSF54862; 4Fe-4S ferredoxins; 1.
DR SUPFAM; SSF142019; Nqo1 FMN-binding domain-like; 1.
DR SUPFAM; SSF142984; Nqo1 middle domain-like; 1.
DR SUPFAM; SSF140490; Nqo1C-terminal domain-like; 1.
PE 3: Inferred from homology;
KW 4Fe-4S {ECO:0000256|ARBA:ARBA00022485};
KW Flavoprotein {ECO:0000256|ARBA:ARBA00022630};
KW FMN {ECO:0000256|ARBA:ARBA00022643}; Iron {ECO:0000256|ARBA:ARBA00023004};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Oxidoreductase {ECO:0000313|EMBL:KPI11366.1};
KW Translocase {ECO:0000256|ARBA:ARBA00022967}.
FT DOMAIN 325..369
FT /note="NADH-ubiquinone oxidoreductase 51kDa subunit iron-
FT sulphur binding"
FT /evidence="ECO:0000259|SMART:SM00928"
FT REGION 513..539
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 539 AA; 56121 MW; 16B1574AAA598E64 CRC64;
MNEALPDVPE VRVVGLPQLT SGFDLVERLD LPMHLKVHGP LEPMGGEQLA GLAEAIGLKG
RGGAGFPFAK KLRSVAESAI SKGIRPVVVV NGSEDEPACR KDTVLINRAP HLILDGALLA
AEAMGARTLV IGVTRESTQR SMEAALAERG LSDRRGSPLR ARVQRNPVRM VTGAAASLIR
SIDGGPAIPP GRKISASQSG VGGAPTLLSN AETYAQLAIA ARIGPDRYRN TGLYDEPGTV
MLTISGAVAR PMVIEVPTGV PLRYVLQLAG APPMPQGVLT GGYHGKWLDA ATVNEAIVSR
NSLDAVGGAL GAGAILPITQ ETCPLGESLR VAQWLAEESA GQCGPCYLGL PAAARGLEDI
LNGGGPAALE AVKQVAKAVK RRGACSHPDG SAMFIESTIK AFTDDLAAHV LGNGCGRPVE
GVLPLFEGGQ LPTGIPGGQA VEEAGPSRQK IYVDWTLCRG HGLCADILPE VFELGADGFP
TVAQAQVPRY AEAKALRAVR RCPALALRIE EDSRSSAPAR NNLPVLSQRR GRRALGSGR
//
