ID   A0A0N1GPA2_9ACTN        Unreviewed;       755 AA.
AC   A0A0N1GPA2;
DT   09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT   09-DEC-2015, sequence version 1.
DT   27-MAR-2024, entry version 38.
DE   RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE            EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN   ORFNames=OK006_3442 {ECO:0000313|EMBL:KPI14003.1};
OS   Actinobacteria bacterium OK006.
OC   Bacteria; Actinomycetota; Actinomycetes.
OX   NCBI_TaxID=1592326 {ECO:0000313|EMBL:KPI14003.1, ECO:0000313|Proteomes:UP000037912};
RN   [1] {ECO:0000313|EMBL:KPI14003.1, ECO:0000313|Proteomes:UP000037912}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=OK006 {ECO:0000313|EMBL:KPI14003.1,
RC   ECO:0000313|Proteomes:UP000037912};
RA   Brown S.D., Utturkar S.M., Klingeman D.M., Pelletier D.;
RT   "Draft genome sequences for four Actinobacteria strains OK006 OK074 OV450
RT   and OV320.";
RL   Submitted (SEP-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC         Evidence={ECO:0000256|ARBA:ARBA00034618};
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KPI14003.1}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; LJCU01000109; KPI14003.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0N1GPA2; -.
DR   PATRIC; fig|1592326.3.peg.3872; -.
DR   Proteomes; UP000037912; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 3.
DR   Gene3D; 3.30.2310.20; RelE-like; 1.
DR   InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR   InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR035093; RelE/ParE_toxin_dom_sf.
DR   InterPro; IPR014016; UvrD-like_ATP-bd.
DR   PANTHER; PTHR11070:SF2; ATP-DEPENDENT DNA HELICASE SRS2; 1.
DR   PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR   Pfam; PF00580; UvrD-helicase; 1.
DR   Pfam; PF13361; UvrD_C; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   SUPFAM; SSF143011; RelE-like; 1.
DR   PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW   ProRule:PRU00560};
KW   Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW   ProRule:PRU00560};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW   ProRule:PRU00560};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW   ProRule:PRU00560}.
FT   DOMAIN          261..565
FT                   /note="UvrD-like helicase ATP-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS51198"
FT   REGION          463..483
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        463..481
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         282..289
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ   SEQUENCE   755 AA;  84245 MW;  804B4554FB23E207 CRC64;
     MTSTGAPTTG ATLRLLDKAD KEIVKLDRAI VGAVYKFQHE FRRNPESPGF DLKPLKGHER
     LWSARVNREY RALLVRLGGN DWLLVSVKHR GHVHRNLDRL AYGINQITGA IEYVDLQVVE
     DGVLGTEGAG ARPEPSALES AAADTPLFAA YTARQLADLG VAEPLIPIVL KLTTDDELLG
     LAEYAPRHTG EVLLRLRDQV PYEQVMEEVT APVAVASEES ADSTRDDWRA AADRSQAVVI
     TDDESLRSIL EEGDFGRWKV FLHPTQEKLV GRGYSGPARV GGGPGTGKTI VALHRVKHLV
     DHLAPGHNKP VLLTTFNKNL AADLRSRLLS LGGPQLLARV DILHVDQLAT RVVSEADPGN
     TKRRIDDTQA LREWRQLLLE IGENRWDAEF LSDEWNQVIL GQAVSSRSDY FRARRAGRGR
     SVSRPDRAEI WQLAERFTQR LDVRGLETHR QVAERAAQLE MARSHKIEER RRQEEERGGP
     GNVHVESGTG AWLRYRYRHV VVDEAQDLGA AHWKMLRAMV PREDDDMFLV GDTHQRIYDN
     QVTLGSLGIN IRGRSAKLTL SYRTTREILG AAIGILEGTD YDDLDGSTDD LAGYRSVLHG
     GRPCLRSADS WDEELDLVAE QVQAWHDVPR ESVAVCVPTN EKVDEVVARL GRRGIVATKI
     TGDGARGAEG VHVGTMYRFK GLEYRRMIIA GVSEGLVPRS TVDTWERTDR LRHRRELQRA
     RSLLFVAATR ARDALTISWN GEPSRFLRPL GAGVH
//