ID A0A0N1GXY9_9ACTN Unreviewed; 332 AA.
AC A0A0N1GXY9;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 09-DEC-2015, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=O-methyltransferase family 2 {ECO:0000313|EMBL:KPI30862.1};
GN ORFNames=OV320_3098 {ECO:0000313|EMBL:KPI30862.1};
OS Actinobacteria bacterium OV320.
OC Bacteria; Actinomycetota; Actinomycetes.
OX NCBI_TaxID=1592329 {ECO:0000313|EMBL:KPI30862.1, ECO:0000313|Proteomes:UP000037870};
RN [1] {ECO:0000313|EMBL:KPI30862.1, ECO:0000313|Proteomes:UP000037870}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=OV320 {ECO:0000313|EMBL:KPI30862.1,
RC ECO:0000313|Proteomes:UP000037870};
RA Brown S.D., Utturkar S.M., Klingeman D.M., Pelletier D.;
RT "Draft genome sequences for four actinobacteria strains OK006 OK074 OV450
RT and OV320.";
RL Submitted (AUG-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KPI30862.1}.
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DR EMBL; LJCX01000020; KPI30862.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0N1GXY9; -.
DR PATRIC; fig|1592329.3.peg.1944; -.
DR Proteomes; UP000037870; Unassembled WGS sequence.
DR GO; GO:0008171; F:O-methyltransferase activity; IEA:InterPro.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR031725; ASMT_dimerisation.
DR InterPro; IPR016461; COMT-like.
DR InterPro; IPR001077; O_MeTrfase_dom.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR43712:SF2; O-METHYLTRANSFERASE CICE; 1.
DR PANTHER; PTHR43712; PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14580)-RELATED; 1.
DR Pfam; PF16864; Dimerisation2; 1.
DR Pfam; PF00891; Methyltransf_2; 1.
DR PIRSF; PIRSF005739; O-mtase; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS51683; SAM_OMT_II; 1.
PE 4: Predicted;
KW Methyltransferase {ECO:0000313|EMBL:KPI30862.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000037870};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000313|EMBL:KPI30862.1}.
FT DOMAIN 11..92
FT /note="Acetylserotonin O-methyltransferase dimerisation"
FT /evidence="ECO:0000259|Pfam:PF16864"
FT DOMAIN 158..316
FT /note="O-methyltransferase"
FT /evidence="ECO:0000259|Pfam:PF00891"
FT ACT_SITE 243
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR005739-1"
SQ SEQUENCE 332 AA; 35280 MW; C5B96F9007DD7B69 CRC64;
MTNNRPSPVG IMRLINGYWA TGVLAAAATH SVFTHLEHGA GTATELASRA AVAERGAQAL
LDGLVSVGLV ELHEGRYRNT PEAATYLVED SPVSLAPFAR LKLTHTGSLT DLAEVVRAGG
PVKDDAVVEV ANNPHWEGIV TAIAAQSVPA AALAAEVLAL ADAGEISILD VGGGSGIYSG
IWLETNPAAR ATQLDWAPIN EIALRLLAER GVGDRFTTVD GDFHTTDFGT AAYDVAVYSH
IAHQESPESN VEVFTRLRQA LKPGGTLVVN DYVVDDDRSG PAFPLIFASE MLLKTRQGST
WTRSDYRDWL VKAGFEDVSF HTAEPATLVV AR
//
