ID A0A0N1HCL5_9EURO Unreviewed; 554 AA.
AC A0A0N1HCL5;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 09-DEC-2015, sequence version 1.
DT 08-NOV-2023, entry version 33.
DE RecName: Full=Vacuolar protein sorting-associated protein 17 {ECO:0000256|PIRNR:PIRNR011791};
GN ORFNames=AB675_9801 {ECO:0000313|EMBL:KPI42476.1};
OS Phialophora attinorum.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Chaetothyriomycetidae; Chaetothyriales; Herpotrichiellaceae; Phialophora.
OX NCBI_TaxID=1664694 {ECO:0000313|EMBL:KPI42476.1, ECO:0000313|Proteomes:UP000038010};
RN [1] {ECO:0000313|EMBL:KPI42476.1, ECO:0000313|Proteomes:UP000038010}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 131958 {ECO:0000313|EMBL:KPI42476.1,
RC ECO:0000313|Proteomes:UP000038010};
RA Moreno L.F., Stielow B.J., de Hoog S., Vicente V.A., Weiss V.A.,
RA de Vries M., Cruz L.M., Souza E.M.;
RT "Draft genome of the ant-associated black yeast Phialophora attae CBS
RT 131958.";
RL Submitted (JUN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Component of the membrane-associated retromer complex which
CC is essential in endosome-to-Golgi retrograde transport.
CC {ECO:0000256|PIRNR:PIRNR011791}.
CC -!- SUBUNIT: Component of the retromer complex.
CC {ECO:0000256|PIRNR:PIRNR011791}.
CC -!- SIMILARITY: Belongs to the VPS17 family.
CC {ECO:0000256|PIRNR:PIRNR011791}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KPI42476.1}.
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DR EMBL; LFJN01000007; KPI42476.1; -; Genomic_DNA.
DR RefSeq; XP_018002439.1; XM_018150368.1.
DR AlphaFoldDB; A0A0N1HCL5; -.
DR STRING; 1664694.A0A0N1HCL5; -.
DR GeneID; 28742248; -.
DR OrthoDB; 1708746at2759; -.
DR Proteomes; UP000038010; Unassembled WGS sequence.
DR GO; GO:0005829; C:cytosol; IEA:GOC.
DR GO; GO:0030904; C:retromer complex; IEA:InterPro.
DR GO; GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR GO; GO:0042147; P:retrograde transport, endosome to Golgi; IEA:InterPro.
DR CDD; cd06891; PX_Vps17p; 1.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR Gene3D; 3.30.1520.10; Phox-like domain; 1.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR001683; PX_dom.
DR InterPro; IPR036871; PX_dom_sf.
DR InterPro; IPR014461; Retromer_complex_Vps17.
DR InterPro; IPR037907; Vps17_PX.
DR InterPro; IPR015404; Vps5_C.
DR PANTHER; PTHR47433; VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 17; 1.
DR PANTHER; PTHR47433:SF1; VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 17; 1.
DR Pfam; PF00787; PX; 1.
DR Pfam; PF09325; Vps5; 1.
DR PIRSF; PIRSF011791; Vps17; 1.
DR SUPFAM; SSF64268; PX domain; 1.
PE 3: Inferred from homology;
KW Protein transport {ECO:0000256|PIRNR:PIRNR011791};
KW Reference proteome {ECO:0000313|Proteomes:UP000038010};
KW Transport {ECO:0000256|PIRNR:PIRNR011791}.
FT DOMAIN 125..200
FT /note="PX"
FT /evidence="ECO:0000259|Pfam:PF00787"
FT DOMAIN 256..437
FT /note="Sorting nexin/Vps5-like C-terminal"
FT /evidence="ECO:0000259|Pfam:PF09325"
FT REGION 1..88
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 468..554
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 17..54
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 64..79
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 526..544
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 554 AA; 61224 MW; 1A3389A4A8605DE3 CRC64;
MDYSTDALAG PSPWGSSSPK AGRTHQHNAS QDSVTGPPAA QSEPTEPEQQ QAVGQEQHEQ
HEHPQGQPTF QQRQAAARYQ RQQRPVPAYK LQSKVTALER TGRKDPVIRF DVYTNLPKFR
TTQFRDVRRT HGEFVKLSEH LISSNPEALV PAVPPAVTSA GAGTDEDEGR VKNSIQRWLN
NVCGNDVLMR DEEMVFFVES DFGYSPVVRM KQPATGVRRK VLKQFAPPPD DTPELHEARP
PVKAFYLGAL DAGQKLEKVV KHRRALGLAE TSLGEKLTQL HVQETHGGLA NAYRKLGRVV
QTVGDYHAAQ GTAEATTLGD PLAYHAADAF IVKESLTNRH ILLRELLQAE QARRSKEAAV
TRLKSSTSVK RDKVDEAISA LDEAKSAEEY LLGKTQRVTG NLLLEKRRWF RRTSEDMLDA
IREYAVRQIE TERRTLATLE SVRMDVRQID ASGGLSRLGR EANPQIRRVS MASSQTAKGD
AWSGVERTRT GLARTLSGSL GGLPEQDEDS KANGDHDAVA GTGRPRGDSI KEDDEGDDRV
DARNAASRLA QSTF
//
