ID A0A0N1I4F9_LEPSE Unreviewed; 4118 AA.
AC A0A0N1I4F9;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 09-DEC-2015, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE SubName: Full=Putative dynein heavy chain {ECO:0000313|EMBL:KPI87221.1};
GN ORFNames=ABL78_3691 {ECO:0000313|EMBL:KPI87221.1};
OS Leptomonas seymouri.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leptomonas.
OX NCBI_TaxID=5684 {ECO:0000313|EMBL:KPI87221.1, ECO:0000313|Proteomes:UP000038009};
RN [1] {ECO:0000313|EMBL:KPI87221.1, ECO:0000313|Proteomes:UP000038009}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 30220 {ECO:0000313|EMBL:KPI87221.1,
RC ECO:0000313|Proteomes:UP000038009};
RX PubMed=26317207;
RA Kraeva N., Butenko A., Hlavacova J., Kostygov A., Myskova J., Grybchuk D.,
RA Lestinova T., Votypka J., Volf P., Opperdoes F., Flegontov P., Lukes J.,
RA Yurchenko V.;
RT "Leptomonas seymouri: Adaptations to the Dixenous Life Cycle Analyzed by
RT Genome Sequencing, Transcriptome Profiling and Co-infection with Leishmania
RT donovani.";
RL PLoS Pathog. 11:E1005127-E1005127(2015).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KPI87221.1}.
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DR EMBL; LJSK01000097; KPI87221.1; -; Genomic_DNA.
DR EnsemblProtists; KPI87221; KPI87221; ABL78_3691.
DR VEuPathDB; TriTrypDB:Lsey_0097_0080; -.
DR OMA; NWMYLEF; -.
DR OrthoDB; 166463at2759; -.
DR Proteomes; UP000038009; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR Gene3D; 1.10.472.130; -; 1.
DR Gene3D; 1.10.8.1220; -; 1.
DR Gene3D; 1.10.8.710; -; 1.
DR Gene3D; 1.20.1270.280; -; 1.
DR Gene3D; 1.20.58.1120; -; 1.
DR Gene3D; 1.20.920.20; -; 1.
DR Gene3D; 1.20.920.30; -; 1.
DR Gene3D; 3.10.490.20; -; 1.
DR Gene3D; 6.10.140.1060; -; 1.
DR Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 5.
DR Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR035706; AAA_9.
DR InterPro; IPR041658; AAA_lid_11.
DR InterPro; IPR042219; AAA_lid_11_sf.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR041589; DNAH3_AAA_lid_1.
DR InterPro; IPR042222; Dynein_2_N.
DR InterPro; IPR043157; Dynein_AAA1S.
DR InterPro; IPR041466; Dynein_AAA5_ext.
DR InterPro; IPR041228; Dynein_C.
DR InterPro; IPR043160; Dynein_C_barrel.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR InterPro; IPR013602; Dynein_heavy_linker.
DR InterPro; IPR042228; Dynein_linker_3.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR45703; DYNEIN HEAVY CHAIN; 1.
DR PANTHER; PTHR45703:SF34; DYNEIN HEAVY CHAIN, CYTOPLASMIC; 1.
DR Pfam; PF12774; AAA_6; 1.
DR Pfam; PF12775; AAA_7; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF12781; AAA_9; 1.
DR Pfam; PF17857; AAA_lid_1; 1.
DR Pfam; PF18198; AAA_lid_11; 1.
DR Pfam; PF08393; DHC_N2; 1.
DR Pfam; PF17852; Dynein_AAA_lid; 1.
DR Pfam; PF18199; Dynein_C; 1.
DR Pfam; PF03028; Dynein_heavy; 1.
DR Pfam; PF12777; MT; 1.
DR SMART; SM00382; AAA; 3.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Dynein {ECO:0000256|ARBA:ARBA00023017};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741}.
FT DOMAIN 1372..1511
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 1653..1853
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2080..2236
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT REGION 1..23
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 359..386
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2897..2959
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 4118 AA; 466577 MW; 1021E7C497AFE663 CRC64;
MSSEKLSSFQ HKLAESAKPK PVATSQLQAN VNVGLARSQD APQLYRFQNP SNFTFLGSSA
ASERLAQKLR RAENGSAAAE SESVAALCDE KDVELLRMIQ KASRRPAKTA EKRVAPDDEP
LLRNIHTAED AVAFFTANGN STSLKHVFLN CAPKGLVFRP YDLVVTKKGT ENPEHYILSA
TGIVHMRPGR PSEVMTLADY MKDSSLFNIL RKILFFKNFL LYKAFLRLQM KLRQRKYAAV
RRALFKDLLV AKPTFAFPML DLVKYSRTIS DAKLIEYVPL GKHDYVVDDF TLTQARQRQK
ASVFVNGIIE GMEEKVTKLV EVLQHRADVP DINTREALEQ YLLTVAAGEG ADPRAKRKAK
SMVDAREDLE RRMRELKRSL VEYSKLHLFI RLVDFLASEQ LFQRVLSVAQ TFLNTVRGQV
QCEVRKVGFQ ILLHPEDSTI VFDPKEAVLR GVFTNLLSGC MDAVTICPRL CAQKYLKALF
PTSPKIWDIG DELRSNARVD YIHSALMGVL HNDYEKADGR LITYLTTVPH IQFLKKSWEE
VEDTCKQETS ESILSASSLS KLYRRLQEAQ DALRVLIASY VGCLLWINAS KLKTEIEPRI
VVLRDGMNST LRTTARDLIR ELNTFFKQKS QIMSERPQTL REFAEFAAEY KEIVASAPVT
DAKIAQTEAL CELMDRQQAE FVDDEDKQLR ERTLGGGAAN ISLRSVFDSA RLQADEFIEE
NMPTHVDTLQ SEVATVEEEC AGLNEILLGE EFAVLTDNTE PLLQYLSDIS TKLSEIDARE
KQLSSYAKLF NQGSFDWSFV SEVRTLFQAR DEAWNLLDTF NKKAERWFEI PVKELDTLEM
EEQVNLLVRR AGAVNRLMLE RSYDDEVAGH LLEELQSIRA NMAVIHDCGN KHMTPEHWNM
VLQQITGNAY SYHDDLNLNA LEEWDIFSYK ETLSEQSGLA TGEWKISNDL DAVKQVWDAL
DFTTKPYKNR EGAFILDQLE DVIQQLDDHQ IELQMTMASR FVAPVRDRVE KWIRDLRLVG
DVIDEWITLQ KNWMYLEFIF SSDDIKEQLP EESMMFDNVD RLFRSLTSRA HNQKNVLQIC
IEEGVLDDLR ANNANIDHIQ KKLEDYLETK RIAFPRFYFL SNDELLSILS DVRNPKAVQP
HLSKCFDSIA LLMFSDEECS EIVGMISGEG EQVPFEKPVY PVGNVEQWLS EIERMMKASL
YMHMQLTLEM VTQRKREEWI FQHPAQCIQA VDMIMWTGQV EAAIDSASLA SYYREYHGQI
LRMVELTREP LSKLQRMLVG TLIVLNVHNR DIVQSLSEGS VTSLDDFAWY QQLRYYWEDC
GRHIQSGEKN IGIHHCNAHL WYGYEYLGNQ ARLVITPLTD RAFLTCTNAL AMNLGAAPQG
PAGTGKTESV KDLGKALARQ VVVFNCSDGI HYKTMSRMFA GLAQAGAWAC FDEFNRIELE
VLSVIAQQML DITTALSHKL TRMDFDGHPI QLSPNFGVFI TMNPGYAGRT ELPDNLKALF
RPICMMIPDY ALIAEIMFYS EGFADARTLA QKMVQLYKLS SEQLSKQDHY DFGMRAVKSI
LVMAGSLKRQ SPNESEDMLL IRAMRDANVP KFLRDDTTLF MALVRDLFPT VSMEEAPNML
LVDYMKRQLV DDGRQVVEGM VTKAIQLYDT LVVRHGVMLV GQTFSGKSTV LSTVQQALTR
ISEDGHGKGD NTPLFNKVHL LQLNPKSVSM GELYGQVNDI TREWTDGILS SIARNITRAA
LTQPDRQWVV FDGPVDAVWI ENMNTVLDDN KLLCLFNGER IKLPSTATFM FELQDLRVAS
PATVSRCGMV YLEPYYLDGH RGWVPIARSL VESKAKADTR LRKDRLLELL DLLLPDTLEF
IRAHCREWIP SVDAQLAVNC VELLQGFLAT CEDTKVWPRE AVQPIDAGTD DGDDEANNQR
AEAPALAATG RNSSAAATLP IHSTPAEFAR PPVTNATAPT LEESRLFDMY FFMAFVWSVG
SNLRDDSREL FSTFLKEKVT VALPGLLPTQ TTAADAAATS DDAKVSVYDY VVHRPSMQFI
TWNHLVPTFL YSRSIPYFEL VVPTAEGVAF NTLLSVLTKS SQHVLVNGVT GTGKSLGVLN
FLNNSLHVDD PSSAWESFSV VFSAQTRSKD IEDRLENKLY KIRSTALGPS PGKHAILFVD
DINMPTPEIY GASPPLEMLR QLITQRGFYD THKSPPAFKE VHDMIMLAAC GVPGGGRNEM
TQRLTSRFHL ICQPALSESS TRRIFGSLLY GFLQQWDSEE IRGLSSKLVT ATLICYERIT
QEKLPTPTRS HYTFNLRDMG KVIQGIMQTS PRVTTSVAAF HRLFLHEVSR TFHDRLIDTK
DREWWWLTLS DVCQTVLGEK WTPSFEELIF GDFMRRDRAY YQEVTESTDV IAHSLNEYQN
GYNMEYNKEV GLVFFKDAAQ HVARLCRVLR QPRGHALVVG MGGTGRQSLC KLAAFICNLP
VYEVTITRTF NMTEFHDSLK KILLESACHD KPVLFFLSDT QLVKEEMLED INNLLNTGEV
PNLMQSDDID QIVEAVRPYA IAAGKRETRN TIFSHFVSMC RDHVHIVLAM SPVGEQFRRR
LRMFPSLVNC CTIDWFDQWP RDALASVAQR VLAKLPMDEE DKAHLIELCV SIHVDVQEAS
EEFYSVLRRR TYTTPTSYLG LLTSYQQLLE EQNKVVTAQV ERYQGGIDTL RSTQTMVDEM
KVKLIDMQPK LLEAAKSTEE IMGRVEKEQV SAEVVRKQCA EEEAGASEIQ AEADAIRSEC
QAELEKALPI LKAAEDALAE LRPDDIREVR SFLKPASRVV LVLEAVLILL GEKDLSWDRA
KLVMSRMDFI KDLQNYKRDE LTEKIIKALQ KYINNPDFQP DEVAKSSKAC KSLAMWVLAM
NNYYEVVKVV APKRARLAEA EEKVAVATKA LQEARGRLHS IEEKLAALQE EMKENVRKKH
QLEDDIDLTT VRLERAEQLM NGLGSEKTRW VKAVTQLTAE KEGHVGTMAL AAGAVAYLGP
FTSTYRGRLL RAWYDKCVEL GLPVGQTEFQ LSSIMDPVRI RTWSQQGLPP DHFSVENGVV
VSKSHRWCLC IDPQGQAVNW IRSMERDNSL RVVKLTDANY MRTLENAIRV GLPVLIENVG
ESLDAVLDPV LLRQTYHSQG RLLIKLGDNE IDYDPNFRLY MTTKLSNPLF LPELQIKVTV
VNFTVTQTGL ENQLLADVVR VEMAELEQRA DQTVLDIAHG KDELKSLEDK ILHLLGSSTG
NILDNEQLVN TLQEAKSTSE SVGNALRLAE ETQRDIGAAR DRYRPVAQRG ATVYSVITEL
AGLNHMYQNS LDFFKQLFVL TLKQTEKNDD VEQRVTTLLP AVTLRSYNTI CRGLFETDKL
IFAVLLYVHI ARQKGTVSDD EWSFMLKGSE GKRYVDEEVD PPPVWMNVTS WNELSALGAT
ISSFAFLKDA VIDHEDEWAA WSANDKAYEG YPASLGKYTG WQRLLVLKVF RDDLLNYGLS
LLIEQELGKA FTESPAFDLE GCFRDSTPIA PIIFVLTAGT DPTQLFTEFA ERKGFGSRKM
MLSLGQDQGR KAEEMIRVAS TESGSWVYLQ NCHVYSSWMP SLERILEDLT RRDVQRDFRL
WLTTMPVASF PVLLLQSGVK VVKEPPQGLK ANMRDTFSVA VTSELWDSCP RNPTTWRRML
LSLTFFHAVI QERRRFGPLG WNIPYQWSQP DLSASVQALQ TYLRDEGDAV PWNALRYMVG
VINYGGRVTD FLDSRCLATI LEKFFNENVV VPDTEVDFSA DGVYRIPADV KSLEDIRTYL
NDLPTFENPE LFGLHANADI TFNKNTIRRQ LASILSVQPR TKVAAGRSPE EKALELVIEF
QRLLPAPIDK AQAHPDTYRL TDDGTMISLG TVVGQEVIFF NSVLAKLKRT LHLLECAIKG
EVVMSAELEA MFDAILLGQV PQMWHDGGYL SRKPLASWFN DTLRRIDFFR EWNDHGTPTS
FWISGFFFPQ GFLTGVLQTH SRLHRIPIDE VKFRTNATRY ETPDDVVEEV ESGVLIYGVY
VEGAGFDIKA RTLVESKPGE LYTPMPVIHL QPVRGSEQTA TAETYACPVY KTSARVGTLS
TTGLSTNFVV SLDLTSTPGV QPDHWTERGV ALLCMLDD
//
