ID A0A0N1I6I1_PAPMA Unreviewed; 677 AA.
AC A0A0N1I6I1;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 09-DEC-2015, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Rab5 GDP/GTP exchange factor {ECO:0000313|EMBL:KPJ07388.1};
GN ORFNames=RR48_03380 {ECO:0000313|EMBL:KPJ07388.1};
OS Papilio machaon (Old World swallowtail butterfly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Papilionoidea;
OC Papilionidae; Papilioninae; Papilio.
OX NCBI_TaxID=76193 {ECO:0000313|EMBL:KPJ07388.1, ECO:0000313|Proteomes:UP000053240};
RN [1] {ECO:0000313|EMBL:KPJ07388.1, ECO:0000313|Proteomes:UP000053240}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Ya'a_city_454_Pm {ECO:0000313|EMBL:KPJ07388.1};
RC TISSUE=Whole body {ECO:0000313|EMBL:KPJ07388.1};
RX PubMed=26354079; DOI=10.1038/ncomms9212;
RA Li X., Fan D., Zhang W., Liu G., Zhang L., Zhao L., Fang X., Chen L.,
RA Dong Y., Chen Y., Ding Y., Zhao R., Feng M., Zhu Y., Feng Y., Jiang X.,
RA Zhu D., Xiang H., Feng X., Li S., Wang J., Zhang G., Kronforst M.R.,
RA Wang W.;
RT "Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.";
RL Nat. Commun. 6:8212-8212(2015).
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DR EMBL; KQ461186; KPJ07388.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0N1I6I1; -.
DR STRING; 76193.A0A0N1I6I1; -.
DR InParanoid; A0A0N1I6I1; -.
DR Proteomes; UP000053240; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0016192; P:vesicle-mediated transport; IEA:InterPro.
DR Gene3D; 1.10.246.120; -; 1.
DR Gene3D; 1.20.5.4770; -; 1.
DR Gene3D; 1.20.1050.80; VPS9 domain; 1.
DR InterPro; IPR041545; DUF5601.
DR InterPro; IPR003123; VPS9.
DR InterPro; IPR045046; Vps9-like.
DR InterPro; IPR037191; VPS9_dom_sf.
DR InterPro; IPR002653; Znf_A20.
DR PANTHER; PTHR23101; RAB GDP/GTP EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23101:SF122; RAB5 GDP_GTP EXCHANGE FACTOR; 1.
DR Pfam; PF18151; DUF5601; 1.
DR Pfam; PF01754; zf-A20; 1.
DR SMART; SM00259; ZnF_A20; 1.
DR SUPFAM; SSF57716; Glucocorticoid receptor-like (DNA-binding domain); 1.
DR SUPFAM; SSF109993; VPS9 domain; 1.
DR PROSITE; PS51205; VPS9; 1.
DR PROSITE; PS51036; ZF_A20; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000053240};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 7..41
FT /note="A20-type"
FT /evidence="ECO:0000259|PROSITE:PS51036"
FT DOMAIN 230..375
FT /note="VPS9"
FT /evidence="ECO:0000259|PROSITE:PS51205"
FT REGION 39..73
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 438..466
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 560..591
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 633..677
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 43..57
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 58..73
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 438..457
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 568..583
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 640..654
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 677 AA; 76121 MW; 07C8B34126D4E28D CRC64;
MPSLRIDQSD LKCKNGCDYY GNPQWQGYCS KCHREQLQRQ RRAEKASAAS ASATLPRQEQ
KKPERGLKLS SHSSFSKFEE KRLRQSETLK KANLLKFSVF KKSSADEHEQ SERRPQEFKV
PSMVNEGMKR DFRARFPQLP SQVDRDARVF AHSFIMDVIK CSNVMSVDEL SERVQRQYQR
FMRHMDTSQH FAGLDQDTKE LLIDFVEKHV MTYLHELPGV VFSPAGTEDE RADRAMSERI
QQLGWVGERH LDCDLDRSNA ACRQLLYKAI SELLGMDGCA APGGKLARVR RCCRHVLALA
GPPASADDLL PRLIFTCCAV SFIENLTAES LNMDKQEFDC YMAMPASIGG SAWAAALSLC
ACAREAEEQR AHAQRLLQQL DEIDSRSNTL ADNAASFEEQ IAKKVQDVLA KTPLEIKPRR
ELPRFGKFKS IAATPLIDID TPTSASDPAP TTPHQTENNE IQKEHEIPVV ETTVVEDKQD
ILDFQVLEKP SPSKSPNNVD EKWDLKQTNS MELLTPSPLG FTPFDSRSID ELVTPEDFGT
ENLAPGLSNI NYDIDLSDFS GDNSLAEDPP KSEPKDPFSP DGIKKDFDPF APLPSRSEYS
AILETFDEFS LVDARNVSSE AFEVVHRGRD PFSPVLTEHR HPFNTANQHT SLLDDKESPT
AECLLPSPLQ PQTSKSN
//
