ID A0A0N1I763_PAPMA Unreviewed; 3549 AA.
AC A0A0N1I763;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 09-DEC-2015, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE SubName: Full=Lysosomal-trafficking regulator {ECO:0000313|EMBL:KPJ13328.1};
GN ORFNames=RR48_03536 {ECO:0000313|EMBL:KPJ13328.1};
OS Papilio machaon (Old World swallowtail butterfly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Papilionoidea;
OC Papilionidae; Papilioninae; Papilio.
OX NCBI_TaxID=76193 {ECO:0000313|EMBL:KPJ13328.1, ECO:0000313|Proteomes:UP000053240};
RN [1] {ECO:0000313|EMBL:KPJ13328.1, ECO:0000313|Proteomes:UP000053240}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Ya'a_city_454_Pm {ECO:0000313|EMBL:KPJ13328.1};
RC TISSUE=Whole body {ECO:0000313|EMBL:KPJ13328.1};
RX PubMed=26354079; DOI=10.1038/ncomms9212;
RA Li X., Fan D., Zhang W., Liu G., Zhang L., Zhao L., Fang X., Chen L.,
RA Dong Y., Chen Y., Ding Y., Zhao R., Feng M., Zhu Y., Feng Y., Jiang X.,
RA Zhu D., Xiang H., Feng X., Li S., Wang J., Zhang G., Kronforst M.R.,
RA Wang W.;
RT "Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.";
RL Nat. Commun. 6:8212-8212(2015).
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DR EMBL; KQ460642; KPJ13328.1; -; Genomic_DNA.
DR STRING; 76193.A0A0N1I763; -.
DR InParanoid; A0A0N1I763; -.
DR Proteomes; UP000053240; Unassembled WGS sequence.
DR GO; GO:0031123; P:RNA 3'-end processing; IEA:UniProt.
DR CDD; cd06071; Beach; 1.
DR Gene3D; 1.10.1540.10; BEACH domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 3.60.15.10; Ribonuclease Z/Hydroxyacylglutathione hydrolase-like; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR000409; BEACH_dom.
DR InterPro; IPR036372; BEACH_dom_sf.
DR InterPro; IPR001279; Metallo-B-lactamas.
DR InterPro; IPR023362; PH-BEACH_dom.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR036866; RibonucZ/Hydroxyglut_hydro.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR13743; BEIGE/BEACH-RELATED; 1.
DR PANTHER; PTHR13743:SF163; LYSOSOMAL-TRAFFICKING REGULATOR; 1.
DR Pfam; PF02138; Beach; 1.
DR Pfam; PF16661; Lactamase_B_6; 1.
DR Pfam; PF14844; PH_BEACH; 1.
DR SMART; SM01026; Beach; 1.
DR SMART; SM00320; WD40; 3.
DR SUPFAM; SSF81837; BEACH domain; 1.
DR SUPFAM; SSF56281; Metallo-hydrolase/oxidoreductase; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50197; BEACH; 1.
DR PROSITE; PS51783; PH_BEACH; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Reference proteome {ECO:0000313|Proteomes:UP000053240};
KW WD repeat {ECO:0000256|PROSITE-ProRule:PRU00221}.
FT DOMAIN 2730..2839
FT /note="BEACH-type PH"
FT /evidence="ECO:0000259|PROSITE:PS51783"
FT DOMAIN 2844..3142
FT /note="BEACH"
FT /evidence="ECO:0000259|PROSITE:PS50197"
FT REPEAT 3319..3360
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REGION 83..102
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 213..268
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1094..1140
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2087..2109
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3400..3426
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 213..237
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 238..254
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3411..3426
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3549 AA; 386701 MW; 5BDCBC875F945F42 CRC64;
MATEEEPDSL KIYWDHFFKA ETGTYEKSTW LELFLAEFLV RLQEGVDPNQ LIKFCPVSGV
VTLVGCELLC GIHRVTSAAN LHHAAPPPPS APLPALHSGN GIANGHDGDG GGACGARAPA
SVFSRAQAQA QSSGAVLRAY VLRGPAWRCL VLLRTLGVEG LSCCRQLSSV LVWLWGELAG
GAASPGAKPP PASHTPPIHT LFSHRIWTKQ KLNQAPKTSS IASSVRSSAS GRTKHNGVSK
LDSNDAKSNR RSLAETEQST ESADSNDDLH ILNKSMAIKV SAPSDQFEYF ESPKRSSNDY
PNEMLYTDPF YTPRKSKPKA DDYINDKHKE IINTEISSFD FMLLITELLQ ELCKAESSLS
GAEGSQISMQ CINFSLKNLC SLQFGSLPAQ ANYNGEEMSR IKLALTELLI VSLDKVLIHS
GLCAKLINSG ILPMLLRILE DVICKSNAKY NTKEDRLSQP KDVEKSNENE AENLLKYVFG
IAYSITAFFH CLLMQCRTVD KLREFTDQFK LYGECLKGGL LKECIELMIR IPHAEEETSV
ILIKKLIESI GKLVSGMKRV RSEVIHSAAC GRSWHKACRP RVAAGMHHHH DVLGEAGPGL
PLPSACCVSV LYGTLTALVT DDRVSAQPEL RTKILRVMLK CGVCCCFSPG FLMECIVRLM
LTHNSVAPRC LQLLEHTVYG DLGSSILIPR VTDQLPCSIC EPCDDNKDLG RKYCHHGVSP
IERKSVWSFL IHYNSLLQLD NHNNVLHAAV SHLLKVTPKC RMEMKYELLF SVIYPTFIVS
KHRYIIKREE SAYFLTVSCL NIFASLLNTV SFAEQFIQKG GLSYVLELVS LPEFSNQCCA
ILEIAIIVEI YKLMKENAEL TYFREISSLA SVQMLFKCLS EVTERCYNMY KLQLPADKFE
ELCDLTREKE ILDMNTELEE RFSTTNNTLV SNDKAEESSE DYIEALKTIG TFWKSCAGLC
LLCPMFREHV SRAPLLAHSY ALLKLALHRL CQPAPSAAPA ETRLLVALME ALLTVQFAVS
DPTKGRSRTA SCGVVRSALR AATAATAATA ATANTTPAMC SGAGLSALCD ALIGVAVARP
SRRLAMPRLA PAKVPPLQCE SSGSSVEGSS GEEAGPLGSS HASPYASELS DPHPLDDDGY
EADVEAGKLA AARGAPRDLA HTMSVLGGLS EYQSPMEALC GGHAAPGPGL AHPELCLVVV
DILSQLLQRV VEEESNNGTQ ESLERVCGGL ARALAARLAG GGAPAGLLRR LLTPPAAALL
RRTDPRLAEL QHSILELIHV VASQSVEPRE LAALLQLAAA DRPPLAALLS ALQRLLAHAD
PCTPDFALQF PIQLSPHASD EPTTSLGAGA ARCVVDGANW GPWLQGFALV LWLQPLPEAK
NEDYDEVDRA VPMRQETGEV CGEPAAAAVH VLSLGQDSLT FELWLNVATA NNVVCGVRRA
VCAAVSWRGR VRGRVRGRVR GRGGGGRGGA RVLCEGSAAC RLRPARWSCL ALNVREAVLR
RKIHIQVTFY LNGRECDTVS LPLQGILVRK ISATSVSLGQ VSGAGAGAGA MWRLGPLALY
RAAVLSAPAA LHLAAHGPDH ACQVRCEEPN YSAILTPDVL DINVDWEQVF EMPMAALREL
HDQLLATYSA HAHEHVNLYQ QVSAPQTVSG FSGRGGGCAG SGVADTLHVQ WAGPAHVQRH
RGFAPALLLL GGPEILLYLF ARVFEMPAAA LRELHDQLLA TYSAHAHQHI NLYQQVSAPQ
TVSGFSGRGG GCAGSGVADT LRVQWAGPAH VQRHRGFAPA LLLLGGPEIL LYLFARVVEA
GGSAEQQAAA LGVALRAGRA DARLHAALYA RDALQLLLPV LAAPACRVSH HMLKEILDVA
CTGPLLSVSG QSVRLAARAD CALREPRLLL LLLRAWPHLH TVQVSWEVEG GEVTENGSLW
ALALEAICAL LRDGPRRAFN QHQAARAHLL RHLLLACKER FLNSDSGPLS TSASNSLVEL
VRALVGTPPL PAHLALLCDF LLLMHQASDT FVTHSRANFY FLLTAESPEA SEFNFLTFMN
KRKNKQHKLR KSLESLALND PPEESNAGAD NTKHMKGIIN AHIRDSRKEN GAATQTNGTT
IGEGGEGGEG GADALSGYVL VDEDELRHTT VELYTGGIYH QRRVRAGAEP GWTACAGVLL
LLRDSLAALP DHLLAQQTVC GPVLAESLVV LANHRTACVR AAVVRCVCAL QRRAPRALAH
TAAGAHYYTH LADQISLYPG SWELATACAA LLTKCDVPLE DQLDDDIWVE LGEEAAQRGA
PLLALLPVSL HSVPLAHNVT LLLRRLVHKV SLKALTEVAL AEVVVRAVRD LGRMDEEFEG
RDLLLEDLFD LLNKLAVKAL ANNHTMQCAV DIHQQLRYVS GTARGRGAAG VRRLARAAEA
ALFAAQLDHL EAHLDHCYAT HNKHTNYFAN VLGGAESGRA RSELCARYSG TLARALAFLL
ARSPRAALHA TSRPRTPPAC TKYVPLSAYL LIMLQHIHAA GGAGVELAIT DWARDWAVAT
QAGLAERLPC DALPAEAERF LAEDEERWTK AGDGPRQRAA VGKAVFTREV VAARCTESAM
AVTRRVVEAQ NGERKHFLEH LRRAHAAAAL AAARWRRLID THTHERGQCT TRETPQLDLQ
FTPLSIYYVF SLGVWHNPSG WPAAWQLDST EGPGRVRVRL RRAHLRIPAR CFQPHARYKA
EAATQPGPLR SVLGPLLSGA RHGGLAARLQ PTESVAFMAR VHHVTVDRET SGELLLSDRC
IHFVPEWCGE EGEEGAEGAE GEGSSCAAQS WALGSVARVC PRRWCLQERA AELFLLSGHA
HLLAFAATAE RDAFLRALDA AHLPNRTEQE SLSDVMNQWR NGTITNWEYL MALNGLAGRS
YNDLMQYPVL PFIIADYTSK MLDLHDPASF RDLSKPMAVQ NKKREQHYIN TYNDLKAARR
EGCSPLLSRQ PHHYASLYSN SGGVLHYLVR VPPFTELFLN YQDNNFDMPD RTFHSLATTW
RLITHDSPTD VKELIPELFY LPEMFYNDEG LELGVRQCGA RVDAVELPRW AADARLFTLA
HRQALEAPLV TERLPHWIDL VFGYKQTGQA AVDAINVFPA CTYYGFDPSV HEDEVDRTAA
QAMVRTYGQA PRQLLRAPHP HAAPDLAPRT QVHHRRAHTT RAHTTQLCLL RAPHPHPTSR
RAHSNISTEQ MLYTESDLEG SMDRIETINF HEEKDVRGVR FWAYNAGHVL GAAMFMIEIA
GVKVLYTGDF SRQEDRHLMA AEIPTVHPDV LITVTQVSTS CTVGSWSWPA FVGLSSGRVL
ALRATGAAGG GARCSVRQLL AHRAPIAALC VCARATLLVS ADTTGLLLLW DLNRLSYIRT
LPNRERLPVT QVAVSETLSD VASVHELRPA GPRVADHTAE CAETAEPPEP ADAAPEDRES
DGDAYERDAP HKYQSLIRVH TVNGRFVGSV KVSEVVTCIC YSNAPEGASV NCIAAGLRSG
EVRLYSSWDL QLVRSLPAPQ AAPAPLLSLS YSEDSLVLFA AHAGGLLLAW ESPHARAQPP
RIVLATALL
//
