ID A0A0N1I7T1_LEPSE Unreviewed; 1597 AA.
AC A0A0N1I7T1;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 09-DEC-2015, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE SubName: Full=Putative kinesin {ECO:0000313|EMBL:KPI88644.1};
GN ORFNames=ABL78_2248 {ECO:0000313|EMBL:KPI88644.1};
OS Leptomonas seymouri.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leptomonas.
OX NCBI_TaxID=5684 {ECO:0000313|EMBL:KPI88644.1, ECO:0000313|Proteomes:UP000038009};
RN [1] {ECO:0000313|EMBL:KPI88644.1, ECO:0000313|Proteomes:UP000038009}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 30220 {ECO:0000313|EMBL:KPI88644.1,
RC ECO:0000313|Proteomes:UP000038009};
RX PubMed=26317207;
RA Kraeva N., Butenko A., Hlavacova J., Kostygov A., Myskova J., Grybchuk D.,
RA Lestinova T., Votypka J., Volf P., Opperdoes F., Flegontov P., Lukes J.,
RA Yurchenko V.;
RT "Leptomonas seymouri: Adaptations to the Dixenous Life Cycle Analyzed by
RT Genome Sequencing, Transcriptome Profiling and Co-infection with Leishmania
RT donovani.";
RL PLoS Pathog. 11:E1005127-E1005127(2015).
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Kinesin family. {ECO:0000256|PROSITE-ProRule:PRU00283}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KPI88644.1}.
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DR EMBL; LJSK01000044; KPI88644.1; -; Genomic_DNA.
DR EnsemblProtists; KPI88644; KPI88644; ABL78_2248.
DR VEuPathDB; TriTrypDB:Lsey_0044_0150; -.
DR OrthoDB; 47485at2759; -.
DR Proteomes; UP000038009; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR GO; GO:0003777; F:microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR Gene3D; 1.20.58.1980; -; 1.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 2.
DR InterPro; IPR027640; Kinesin-like_fam.
DR InterPro; IPR001752; Kinesin_motor_dom.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR24115:SF1004; KINESIN-LIKE PROTEIN KIFC2; 1.
DR PANTHER; PTHR24115; KINESIN-RELATED; 1.
DR Pfam; PF00225; Kinesin; 1.
DR SMART; SM00129; KISc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS50067; KINESIN_MOTOR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|PROSITE-ProRule:PRU00283};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Motor protein {ECO:0000256|PROSITE-ProRule:PRU00283};
KW Nucleotide-binding {ECO:0000256|PROSITE-ProRule:PRU00283}.
FT DOMAIN 767..1548
FT /note="Kinesin motor"
FT /evidence="ECO:0000259|PROSITE:PS50067"
FT REGION 1..53
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 201..333
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 404..520
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 545..567
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 898..986
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1008..1036
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1093..1141
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1153..1176
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 612..639
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 15..31
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 201..218
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 225..239
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 252..301
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 405..419
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 450..487
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 494..520
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 550..564
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 916..930
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1016..1035
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1160..1176
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 889..896
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00283"
SQ SEQUENCE 1597 AA; 168979 MW; F9BFE8D7B15F7E3B CRC64;
MASHPSIKRG GEQALCTAEQ SSSSTPPKLS STAGPAGLPT VAPHRQSLTS SADSRSACEG
DIYVVDAANS KRFHLAVALQ GPFHPLTCVT HASIQRTVRH TLLPPSSTAT AEPQLKLLFE
GMPLDESTTE TLPNNAVVIV HREAPVQDSP HPHCCSHALS QPAGDGFTVV EMLSDSLLHS
QAVPLQPFCQ PGVRSAMQAN PLSTGVPQSC SRSSREAKFT ANGVRAAGST RNSSAMPAPT
QRLPLRCAYG SEGGGSTSSA VKPSSRTPST PAPSSLQPLS KCARPNNGTP RTLTLATASN
IPSPGPHDDV MPNATAPPSP TKHLFPSPRE RAGNRACAVS KPVLAARAEP FDAFESIGIS
AAMASSPSSI ESMPALQSVN GMRSPVDGAS SVEPPLPIHK GSVASSLSPF RSSQRPTAAG
HAVASPLHFS DTSSTVDSLR DRRRLPPAAL LLSSSSSRQP TAFTSPAFSQ VPPPSVLSRS
VPDSLHLTSV SDAEVGDGNW TSALSTTPPR RTVPASTAPT GAVASSALFH TPERTPDGLR
KAVTTRGATA DVGTRDTSTA TGAAPGFSVK PAASLPAHEG PTTIRSPQLH CSVDVRQAAY
DAQRDAIVNA AAAEQQRLLT RLQQHCDALQ KEKRELLTKQ LNGCRAQEVA SRLRALRAAQ
EAAAAREIDA VRARLGQCRD QILDRWLSVL HTHSGQHDTM SQELLKELET EGEQLSLNCL
SLIASYHSEK ARLQALHQQR LLKEAEVARL KWESHVRRCT TEELRGCLRV VARVRPPLRQ
AWLPDWMLTS TEAGRFDRGY AVQVPPAAVT FPTSNNTRDK NAAAAAPFPC VEVVDPSRNV
CRRYAISAAY GSADGSDDNS QQRLFTEQLQ PLLEHMCRTG QHVAVLAFGT VGSGKTYTLI
GPPVEPPPQW GHGRQSEDET SAKPRASSHH HYGDGTLTFS SEESDEEGEA RVGTDGLLQH
RLGNGATLSS GNAQPRGVTA VGVPPRRGIT RCLDPADKEM EARVLQSMAQ AEAGGRRQRS
SERHTREESR WRAQAGIDGR DGMLPRAVAW LTAHLRANAT ARTEAVGEPI VESVVFSMFE
VYNDHIYDLL RAPPAEASPT KKEQEGGEKQ GRRCRGSGPS PRPRWNAGSL PASRAKDSNP
EGLTELQMEL LPPTGWDSKD AAATLSQQPQ STSQPQWRVK ACEVEVRSAE EALEAIQLGM
QRRRAAATLR NTQSSRSHLF LRFRVEVQRP AMPERASAAA ANASSAAIRS ALDVMQGGVL
TGDAAAGVVS AGNADNGVAQ DASTPKGYNF LCAALVPSSS SASSGADAAT PTNPAAAAAA
PAPTCVTELL FTDFAGSERA DLVGAAGDSL KEAQYISGSL SAVKDVLIAL ARANPCRDAV
AGCDGAFAAT KKVGENATGG PGAAAAASAT VPLAERWGAL VGRPGVTLSR STPVFLQPRF
SQLVGDRFRV PSSEKDSSAE HGLPLRRRTL ALVDAYVAGQ SVAQWWRSWR ASSTYIPFRA
CKTTQLLQSA LGAPCKTLVL ACVRPCTLAE VALPASMRHT KGKRVRELAL ALFDRQAPLM
MAEVHSTLMF ADRINAATHE SDAAATLPSS NTAAARV
//
