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Database: UniProt
Entry: A0A0N1IHQ3_PAPMA
LinkDB: A0A0N1IHQ3_PAPMA
Original site: A0A0N1IHQ3_PAPMA 
ID   A0A0N1IHQ3_PAPMA        Unreviewed;       577 AA.
AC   A0A0N1IHQ3;
DT   09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT   09-DEC-2015, sequence version 1.
DT   31-JUL-2019, entry version 22.
DE   SubName: Full=Inward rectifier potassium channel irk-1 {ECO:0000313|EMBL:KPJ18010.1};
GN   ORFNames=RR48_02781 {ECO:0000313|EMBL:KPJ18010.1};
OS   Papilio machaon (Old World swallowtail butterfly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC   Pterygota; Neoptera; Holometabola; Lepidoptera; Glossata; Ditrysia;
OC   Papilionoidea; Papilionidae; Papilioninae; Papilio.
OX   NCBI_TaxID=76193 {ECO:0000313|EMBL:KPJ18010.1, ECO:0000313|Proteomes:UP000053240};
RN   [1] {ECO:0000313|EMBL:KPJ18010.1, ECO:0000313|Proteomes:UP000053240}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Ya'a_city_454_Pm {ECO:0000313|EMBL:KPJ18010.1};
RC   TISSUE=Whole body {ECO:0000313|EMBL:KPJ18010.1};
RX   PubMed=26354079; DOI=10.1038/ncomms9212;
RA   Li X., Fan D., Zhang W., Liu G., Zhang L., Zhao L., Fang X., Chen L.,
RA   Dong Y., Chen Y., Ding Y., Zhao R., Feng M., Zhu Y., Feng Y.,
RA   Jiang X., Zhu D., Xiang H., Feng X., Li S., Wang J., Zhang G.,
RA   Kronforst M.R., Wang W.;
RT   "Outbred genome sequencing and CRISPR/Cas9 gene editing in
RT   butterflies.";
RL   Nat. Commun. 6:8212-8212(2015).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003822};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003822}.
CC   -!- SIMILARITY: Belongs to the inward rectifier-type potassium channel
CC       (TC 1.A.2.1) family. {ECO:0000256|RuleBase:RU003822,
CC       ECO:0000256|SAAS:SAAS00549381}.
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DR   EMBL; KQ460047; KPJ18010.1; -; Genomic_DNA.
DR   RefSeq; XP_014372249.1; XM_014516763.1.
DR   GeneID; 106721723; -.
DR   KEGG; pmac:106721723; -.
DR   KO; K05330; -.
DR   Proteomes; UP000053240; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005242; F:inward rectifier potassium channel activity; IEA:InterPro.
DR   GO; GO:0034765; P:regulation of ion transmembrane transport; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.40.1400; -; 1.
DR   InterPro; IPR014756; Ig_E-set.
DR   InterPro; IPR041647; IRK_C.
DR   InterPro; IPR016449; K_chnl_inward-rec_Kir.
DR   InterPro; IPR013518; K_chnl_inward-rec_Kir_cyto.
DR   InterPro; IPR040445; Kir_TM.
DR   PANTHER; PTHR11767; PTHR11767; 1.
DR   Pfam; PF01007; IRK; 1.
DR   Pfam; PF17655; IRK_C; 1.
DR   PRINTS; PR01320; KIRCHANNEL.
DR   SUPFAM; SSF81296; SSF81296; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000053240};
KW   Ion channel {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434609, ECO:0000313|EMBL:KPJ18010.1};
KW   Ion transport {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434639};
KW   Membrane {ECO:0000256|SAAS:SAAS00434581, ECO:0000256|SAM:Phobius};
KW   Potassium {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434575};
KW   Potassium transport {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434641};
KW   Reference proteome {ECO:0000313|Proteomes:UP000053240};
KW   Transmembrane {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434543, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00036756,
KW   ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00036755};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00048561}.
FT   TRANSMEM    230    253       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    303    326       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      194    332       IRK. {ECO:0000259|Pfam:PF01007}.
FT   DOMAIN      340    505       IRK_C. {ECO:0000259|Pfam:PF17655}.
FT   REGION      112    138       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   REGION      163    189       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   COMPBIAS    169    189       Basic. {ECO:0000256|SAM:MobiDB-lite}.
SQ   SEQUENCE   577 AA;  65359 MW;  5E830E606B7DB468 CRC64;
     MEFDNERRGS RTRALERSLS YSAAIGNGSG RSSIEIPAMA NTEVYTNEEM KKHYRISQTY
     VEGKEITFPN VVTNVDSNPL QQNINSKISD MSQYSSEDET TDNGLTMTID VETESQSPKS
     SETRHISDAS TQPMVSSNVT NETYDRIDFI ESIYNDPEDL VGGHGYSTPY SKRRKKGKKR
     RRQHGRPIRS RRVVHKSGEE NVPVRTNIPA KSIKYMRDIV NTVINSKWRF IILLMIVAHF
     VFWFVFAAIW YAVASSYRDD IGDGKEHCVI GTSSFAGLLM MSVETQMTIG YGVRYPSEEC
     PEAIIVMVFE IVAGTALSGG LSSLLFTKLV RPNRHLSSVG FSKKATVCLR DGELCLQFRV
     WDLLNLHLIG STITAYMLKP IRTLEGEIVH NYIHPLRLKQ ARAFLLWPVT VAHVIDSRSP
     LYDLSAQDMM DYRFEIVVCL TGSSKNMGTV TQSRTSYLSK EIIWGYRFKN VLKYSKKEES
     YVIDVDNLNT VEQVETPLCS ASRLKLFEDD IKSSNNLLTP TNMSLSPTNM SLSQESSTVS
     KVEESVPSSP IFTRTGTQRS FGWNFRRFYP EENKNGV
//
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