ID A0A0N1III6_PAPMA Unreviewed; 904 AA.
AC A0A0N1III6;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 09-DEC-2015, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE SubName: Full=Atrial natriuretic peptide-converting enzyme {ECO:0000313|EMBL:KPJ16423.1};
GN ORFNames=RR48_05502 {ECO:0000313|EMBL:KPJ16423.1};
OS Papilio machaon (Old World swallowtail butterfly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Papilionoidea;
OC Papilionidae; Papilioninae; Papilio.
OX NCBI_TaxID=76193 {ECO:0000313|EMBL:KPJ16423.1, ECO:0000313|Proteomes:UP000053240};
RN [1] {ECO:0000313|EMBL:KPJ16423.1, ECO:0000313|Proteomes:UP000053240}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Ya'a_city_454_Pm {ECO:0000313|EMBL:KPJ16423.1};
RC TISSUE=Whole body {ECO:0000313|EMBL:KPJ16423.1};
RX PubMed=26354079; DOI=10.1038/ncomms9212;
RA Li X., Fan D., Zhang W., Liu G., Zhang L., Zhao L., Fang X., Chen L.,
RA Dong Y., Chen Y., Ding Y., Zhao R., Feng M., Zhu Y., Feng Y., Jiang X.,
RA Zhu D., Xiang H., Feng X., Li S., Wang J., Zhang G., Kronforst M.R.,
RA Wang W.;
RT "Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.";
RL Nat. Commun. 6:8212-8212(2015).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004401};
CC Single-pass type II membrane protein {ECO:0000256|ARBA:ARBA00004401}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00124}.
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DR EMBL; KQ460226; KPJ16423.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0N1III6; -.
DR STRING; 76193.A0A0N1III6; -.
DR InParanoid; A0A0N1III6; -.
DR Proteomes; UP000053240; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR CDD; cd07066; CRD_FZ; 1.
DR CDD; cd00112; LDLa; 2.
DR Gene3D; 1.10.2000.10; Frizzled cysteine-rich domain; 1.
DR Gene3D; 4.10.400.10; Low-density Lipoprotein Receptor; 2.
DR InterPro; IPR020067; Frizzled_dom.
DR InterPro; IPR036790; Frizzled_dom_sf.
DR InterPro; IPR036055; LDL_receptor-like_sf.
DR InterPro; IPR023415; LDLR_class-A_CS.
DR InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR PANTHER; PTHR24270; LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED; 1.
DR PANTHER; PTHR24270:SF67; PROLOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 1-LIKE PROTEIN; 1.
DR Pfam; PF01392; Fz; 1.
DR Pfam; PF00057; Ldl_recept_a; 2.
DR PRINTS; PR00261; LDLRECEPTOR.
DR SMART; SM00063; FRI; 1.
DR SMART; SM00192; LDLa; 2.
DR SUPFAM; SSF63501; Frizzled cysteine-rich domain; 1.
DR SUPFAM; SSF57424; LDL receptor-like module; 2.
DR PROSITE; PS50038; FZ; 1.
DR PROSITE; PS01209; LDLRA_1; 1.
DR PROSITE; PS50068; LDLRA_2; 2.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00124}; Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000053240};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 213..235
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 520..650
FT /note="FZ"
FT /evidence="ECO:0000259|PROSITE:PS50038"
FT REGION 17..40
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 254..289
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 707..847
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 800..816
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 819..845
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 568..606
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00090"
FT DISULFID 635..647
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 642..660
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 654..669
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 672..684
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 679..697
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
SQ SEQUENCE 904 AA; 100832 MW; 17745F08E050F677 CRC64;
MVNGNYVLYG DRPSSESEIV EDHVHTRAAE KKTKRKPNRT ANELQYSLNL AQLDNETDSV
KYEKKVKEPR LLRYVPTTDV EEHFVSEKFE TYDLKATDEP PRRYAFTKKP KNPADGSINY
AYSRSSSSCS SPNGNLPTIS EHGEQFSTYR IRSIRTPTDE EVSHAYETKL DKYFSRPREV
KTFVAKGSHP DSLYRVPVGS GVASSKVVRV LRILRWPVAL FSVCIALAIF VYFLMPDNLS
SEYSTVNATS WQEDTASAQS RIQPGKPNRK PPEQGQHGPQ KGNIRTKPQE IDFYDAENVK
TIDLKSLMET VTENSEKRTP VPPVFPTHIA PEVQYGNERA DKEKMRSPKL IDTVMNSDES
TLKPHITQSP ERPLAIYFDE GKVATSTETI TRAESNNDIL HYDEKELPKT TEETTSKPYS
PVYKDTSLYI RKEHSKSKQR PTEPDLTQAL HEYYRLTPIN HDNRFTSGHS KLFGISMEDA
QSMKSTTQST LYNTRVSPTL PTWRDNADST TKKYPLNTNL DVSQCRSTHL GLCRGVLPYD
LAGPAATLDG VDVTDLLPQM EYLVSSNCSE RTAHFLCSLL EPECSPTPYL HKMPCYSLCR
AVAEHCDGSI PRDLLGVFGC TRYPTGGCAA ARAPCGAREL PCGDGSCVPS HWACDGAADC
PAAEDEAHCT ACASNEFRCP SGGCVHTRWL CDGYADCPRG EDEAEQQCAA RREHDDEQVA
DADPEPGEEP AGSAPALAVR RPFQTSKGYA DDSVHRNGET ESSKEILMTS DSKNGLKRNF
TRRPSPARLS PYSRPIIHDT KTQSKGKLDP RVKTKTNQRK ASRTTLRTTT TSQHMAETAQ
PPRYQPLQQP GACARLALPQ RRTALRRRQG AWFIAKWAGC HRPVLVAGRK RSESFGDGDA
AAPG
//
