ID A0A0N1IJR8_LEPSE Unreviewed; 3685 AA.
AC A0A0N1IJR8;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 09-DEC-2015, sequence version 1.
DT 27-MAR-2024, entry version 17.
DE RecName: Full=Vacuolar sorting protein 39/Transforming growth factor beta receptor-associated domain-containing protein {ECO:0000259|Pfam:PF10367};
GN ORFNames=ABL78_5548 {ECO:0000313|EMBL:KPI85400.1};
OS Leptomonas seymouri.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leptomonas.
OX NCBI_TaxID=5684 {ECO:0000313|EMBL:KPI85400.1, ECO:0000313|Proteomes:UP000038009};
RN [1] {ECO:0000313|EMBL:KPI85400.1, ECO:0000313|Proteomes:UP000038009}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 30220 {ECO:0000313|EMBL:KPI85400.1,
RC ECO:0000313|Proteomes:UP000038009};
RX PubMed=26317207;
RA Kraeva N., Butenko A., Hlavacova J., Kostygov A., Myskova J., Grybchuk D.,
RA Lestinova T., Votypka J., Volf P., Opperdoes F., Flegontov P., Lukes J.,
RA Yurchenko V.;
RT "Leptomonas seymouri: Adaptations to the Dixenous Life Cycle Analyzed by
RT Genome Sequencing, Transcriptome Profiling and Co-infection with Leishmania
RT donovani.";
RL PLoS Pathog. 11:E1005127-E1005127(2015).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KPI85400.1}.
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DR EMBL; LJSK01000190; KPI85400.1; -; Genomic_DNA.
DR EnsemblProtists; KPI85400; KPI85400; ABL78_5548.
DR VEuPathDB; TriTrypDB:Lsey_0190_0080; -.
DR OMA; CATHRRW; -.
DR OrthoDB; 128716at2759; -.
DR Proteomes; UP000038009; Unassembled WGS sequence.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR InterPro; IPR019453; VPS39/TGF_beta_rcpt-assoc_2.
DR PANTHER; PTHR23323; VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN; 1.
DR PANTHER; PTHR23323:SF26; VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 18 HOMOLOG; 1.
DR Pfam; PF10367; Vps39_2; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 3450..3554
FT /note="Vacuolar sorting protein 39/Transforming growth
FT factor beta receptor-associated"
FT /evidence="ECO:0000259|Pfam:PF10367"
FT REGION 26..45
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 116..184
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 389..440
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 675..727
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 752..781
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1189..1236
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1415..1443
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1627..1662
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1876..1970
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1991..2018
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2791..2896
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2966..3000
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3015..3034
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3126..3153
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3562..3638
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 116..164
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 425..440
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 683..697
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 706..723
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1200..1215
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1916..1970
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2843..2860
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2978..2994
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3685 AA; 388184 MW; BF7DEFB043DBA3AB CRC64;
MYVSGEGLQW YDPALLFPLC PLGGDAGGDD GDSEGDPHTS AGPPSVFQAR GSFSGGGRDV
NMAQVSPAAL NRHVRHRARE LLLDRLSGDT LTSDREACAS VAALVKSLYK GEPVQLTAGT
TTNDSSPKSQ QSHSTSNTNH PTKPTPRGAS SFAANLSGAT LQGDGQRRQR RHHGAHSPMS
MLGAGDARDE LDELFASDAE SAKDYFDDVE EDGAEDEDDD AFSLGGWPGL RSRGRRGEDS
AAAAKHAREL RAYFLSLPAQ LGVQEEPVLC PVDLQADPLA HVVAAAEVFV VVTATVPQTL
YVFDQLNGLP ISSSVLGGMS YTANGSGAAA GSTSYDASAA ARVVACTIDA SDTVQQLWMD
PSGHYCVLAF ASGKCVYFYI PRRPSANPAP GFGGATITAH GATSKGPKEC EKEGDDEGDD
SPSDTHDDGP EIKRRRRQER QKEWREAARR WLRFSLRRHS SSKGDGADDV DGADTLHDRD
AAYRPRGFSL TYVFPQSSSS GRAAATGADD AAPAWGPVPN ALHTATSTLQ ATGSPHSSFA
PSCVGWCRHI TTSGGVAMTT TTSVSAASCP RSILKTRERL PDSHAASPQL ALDTNAATPA
PASSLPPSGA AVEALLGAYR GGKLLACLLT PTGAVDSRVV FTFPKPIALA SIDSITAICA
PALSLYGNYA EGHSDGAYRE ASRDSGRSNS AGRDAGGVSP SSSRHVRWGD DGSSQSNPGR
GDGSGSRYSH GKTFVFPTYT HTPHFLHADE ERHSEANAPM PSAPVAPPAA SVASSTAAGN
HQTQSLQRLH WVVLVSVRNR LYVFATPSTT VDFEELEEIR AVLRTADATD GASSVAGGPS
PSLTRRVLEA ATHRLTGRVE DAFLPYAVDR WSDVGPHGQG SEEHQASLTT APAFSTLARP
PLASHTVGNT SNMEPSATAA PSVDRLRNYI TIEPSAFSKY TCAAYSSGAS QVHTSLPGVT
TAMTTKGAGG PEVSTSIYGV GVGEGKSANA LGRGRDRAAC AVNEACAASP AAPFLLESVT
HGVLHLVLPP PRNSENSSVA APADRWISSS ATAPANGGGD GGDLVTPAAL PPVFYWQYGD
VVVQGVILCG AGGLEVGAKV RELVHRGMQV FASATAATTT DRASPHAYGW SAAHGGCARR
GEAPSAAFSV NTPPTSGLEA GLTAVIDNAL RDTQDLNCFA MQCRATAAES RGGGSRPGSH
ASPRPTSSSS AATAEGMAGQ PGAGATTSRG RKLDASSATQ PVVLPIGLLS VVNANSCLQS
LRGLLDNASV THGGGSELKQ GTSGKTRELT YTRRTLRTTT SLAPNPVWAA HTTGPFPAST
SRNLHGGFVG LGSKEEEAAA VLQASVSAAL QNPLLQFPWT TRLQLRNAER GSAGSGMGVA
DGSRCRRHRH DRHECTDRQP PTPFTHFAAP ATALEDSSDR GAALSAGPTR DRRSSVVSPR
PSAGLGPSFD IPLLSDALAR GDVSADAVRQ LCAVAHAYVR RSPVLFGEPI ERLLRASAAA
TRRPSASVAE SHVRHPHGTA GPLAQCSSLA SLVRGSNAAG DLLSRQRWLS PPYALQRCAS
THSHAGVSAA ATADGRGLPS GTLNCSSSSA QLMQRAYAAM VPVGASERGA REHSGNLSLS
FTNAAVGERK ARGPPSTACS PRLPHADPAA LASPPSGADD VNLNPDGEVL VSMAASYSHI
TFTTTQGVYM LAHAAVLPVV EAALLWRREL VYHAVTTRAS TTTAAGGHTP ASPALPLPRA
LLFTTIADPA AADVFFLASR ARMVRLQAPS LYSSAAGRRQ FVMQLLAKAA ATQQTNVHEP
TPAHLRHPDA LHRSRDAGLS NSSVEADDAG AATGRSVAAA IVEAMKGALP ANETVVVPSS
LSYEVRLKGW LGGAAERKTA DAVRSANHGD WQGNRGDGDN IDGGDGLPHG GRGRQGSTHV
PTSHGDGESV SWRSPHPSRS SSSRRDRFSA STTGTLTSGA RSESQSVDSS LLSLDDVAPQ
GDLEPPAAMM TADVSEQRSR SNNEDRPPRA SSKAAANQLR APMSGAQHFL RHANMRALLL
LTTPSNGFEV PLPPPLHGPE YAQRHQRSPA ATAAAVPVVG AGVERPAHLL EVAAGDPAPA
QHALPQLHMS NSGALRQSSF ARPINGPVAP ASPPIHRSSL RPAFPHPGEG QTAGTFTRFA
SLPALATDAA ARAGASSLLP PYPSQASPAS PGSVASGLAD ASEVKHAATH AHVAPAVTAA
ASGTASRAED HDLVSFLAQN PLLHFLLQRC GTANGGEGGA HAEVGSTSAF RLRKRCASQT
THIVDRTRAV NIPGFGLLPG SAGLPPLTQV TSRAVASLLL QRPTGTSYYC ADHLYELALA
AAACSAHDAS PASRRLAGTR EDVSLLYLVR HAYGGFLLSQ RRFLEAAVQF GKAPDGPTPF
TAVFVELVRG FRESSSLAPL ALFLQLRLRA LEASALGLGG HAMEVSVLAT WLLSLLLEQC
SVARAKRQRH KACRDFSSHG RGSTGLRADV LKGCDGERGT RSRSEAKQEA AGACQSGTAG
LKVRDAAAPS SLDFTRVAWI RRRYHLDHPT ALLEDALLRY GRFVDEAVLS TSVARLASVK
EAILVSELEG SPEKTVLHLV LRENNYFAAL LRLQALLVDP TSQCAQTHHL LQSLICREDP
ADTASGAATS LRSMGGGGVS SLADPGAVPL RTVFYGNTPV ASLPGGAEDA AASLPLPLPA
LRDPAALPRT IASLFERFST LFLRCYPCRF LQDGLLALLY QRQDVPLPSR RLLPALLTYS
LGSNESVLEA TGSPSMVLEL LSVARRAQRQ QRRPTACIAD PEVDSEESGE GRTDARGETK
AVPQSASCKQ GRCAALQQEV GSEHEGSKND ESRRGEAGSS KETEVLPASV PMIHSPASGH
AVDSPLLPSS SLDISPQDTR IYDENIESPK DYAGPLFGQP LRQRQEQQQQ RRQPLVARDH
LMECNRIALS GSSSDKGDRD RAMVLPEERP PSAPRPHTLQ DNPSAGTAAF SSPRWKGQTP
GRLVEDVVRE AAVGCTGDRE AGGGESGMSL PLMHPRHRCS SAESASVALL PVPASPSAVN
REGCNSICSR DDSSSSSNHR EAAHLPFNDL HEASLSTAAV AAAYSAPETA ETDSREGLCM
EEVEEDAELF SDTESDDSGP LMELSGVGAG GDSSFSTAAD ERLSARMRRA QQRRYAAALQ
LRHALNPALT AAVVATAAVN ARDVRASKEN AKCRESGGSG DLQPVPQHAV LEYLEELVVY
RGTQANCFDD ADISVSVTYA NVLARDGGEG ALPKLAEQVA LQHVYKMDAW GLSSSPLSAA
SASEFLLAAS TSSYCLLHLL RLCATHRRWA GCAWMYYALG YYREAVELSL KYVVGEEGVR
LAVRLLQLLQ ERDCRHDEAV RRRQLFSGAL HSAMPAAATV HGSDTGCDYT QRQDVRRSRR
ELWMLVARHL IHGGGDTKHG AQTALQLSLR NGGDNFNVTD VLPELPDTLF MAELKEELLS
SVRGLSFKMR GLRANTNALG RDTRILQREL QVMSNQRLTM QVDERCVLCG QPALARPFTV
YPRCRHLLHV SCGHQARQAI LRREGPRTAQ PREASRASSL LSPRHMRMPS VRAASVRNQT
DDGASNANRP LHPLQERTTA GEGSLSGPSR THDHLGRSCI DEPRVGSMEC LQCARRYLRT
MLDTPLHVAL VGDDVQQSAH RVALR
//