ID A0A0N1INJ2_PAPMA Unreviewed; 1702 AA.
AC A0A0N1INJ2;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 09-DEC-2015, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE SubName: Full=Kinesin-like protein KIF21A {ECO:0000313|EMBL:KPJ07356.1};
GN ORFNames=RR48_04150 {ECO:0000313|EMBL:KPJ07356.1};
OS Papilio machaon (Old World swallowtail butterfly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Papilionoidea;
OC Papilionidae; Papilioninae; Papilio.
OX NCBI_TaxID=76193 {ECO:0000313|EMBL:KPJ07356.1, ECO:0000313|Proteomes:UP000053240};
RN [1] {ECO:0000313|EMBL:KPJ07356.1, ECO:0000313|Proteomes:UP000053240}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Ya'a_city_454_Pm {ECO:0000313|EMBL:KPJ07356.1};
RC TISSUE=Whole body {ECO:0000313|EMBL:KPJ07356.1};
RX PubMed=26354079; DOI=10.1038/ncomms9212;
RA Li X., Fan D., Zhang W., Liu G., Zhang L., Zhao L., Fang X., Chen L.,
RA Dong Y., Chen Y., Ding Y., Zhao R., Feng M., Zhu Y., Feng Y., Jiang X.,
RA Zhu D., Xiang H., Feng X., Li S., Wang J., Zhang G., Kronforst M.R.,
RA Wang W.;
RT "Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.";
RL Nat. Commun. 6:8212-8212(2015).
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}.
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Kinesin family. {ECO:0000256|PROSITE-ProRule:PRU00283}.
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DR EMBL; KQ461187; KPJ07356.1; -; Genomic_DNA.
DR STRING; 76193.A0A0N1INJ2; -.
DR InParanoid; A0A0N1INJ2; -.
DR Proteomes; UP000053240; Unassembled WGS sequence.
DR GO; GO:0015630; C:microtubule cytoskeleton; IEA:UniProt.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR GO; GO:0003777; F:microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR CDD; cd01372; KISc_KIF4; 1.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR027640; Kinesin-like_fam.
DR InterPro; IPR019821; Kinesin_motor_CS.
DR InterPro; IPR001752; Kinesin_motor_dom.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR47969; CHROMOSOME-ASSOCIATED KINESIN KIF4A-RELATED; 1.
DR PANTHER; PTHR47969:SF15; ZGC:66125; 1.
DR Pfam; PF00225; Kinesin; 1.
DR Pfam; PF00400; WD40; 2.
DR PRINTS; PR00380; KINESINHEAVY.
DR SMART; SM00129; KISc; 1.
DR SMART; SM00320; WD40; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS00411; KINESIN_MOTOR_1; 1.
DR PROSITE; PS50067; KINESIN_MOTOR_2; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00283}; Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Motor protein {ECO:0000256|PROSITE-ProRule:PRU00283};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00283}; Reference proteome {ECO:0000313|Proteomes:UP000053240};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT DOMAIN 129..497
FT /note="Kinesin motor"
FT /evidence="ECO:0000259|PROSITE:PS50067"
FT REPEAT 1428..1467
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REGION 633..655
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 681..751
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1098..1122
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1139..1375
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1610..1632
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 512..585
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 757..787
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 821..939
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 985..1049
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 684..723
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 724..743
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1105..1119
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1162..1183
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1230..1244
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1312..1326
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 210..217
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00283"
SQ SEQUENCE 1702 AA; 185250 MW; 89B58BDFACB3D23E CRC64;
MNARRLGRRP GWDVGAARAH FLHPAVAMPP RTEQVAAESH RRCPPLLAAH PLPPFLVALV
YAFPSVYVNF DNASRFSDPS KLLAAFTELR TNQIKAPLSR PRRRGRGIDL YTQTDRRYAH
VDMASNESSV RVAVRIRPQT PGEVVEGCGV CARAGGAAGD GGVALGAERA FTFDYAFEPS
APQETVYETC VRKLVEAALD GYNATVLAYG QTGSGKTYTM GSGWEGEGDG DEARRGIIPR
AIRDLFAGAE QRAEAARAQG QLPPEFSVQA QFIELYNEDI VDLLDPAKDP FAKTQPLDNV
CRQGALRITE DGCGGVKVVG ASMRAVRGVR DALGALHAGA LARTTAATNM NSSSSRSHAV
FTLLLRQRRL ATDQDTVDKE ADADAPEQYE TLTAKFHFVD LAGSERLKRT GATGERAREG
ISINCGLLAL GNVISALGDK SRKVLHVPYR DSKLTRLLQD SLGGNSNTVM IACVSPSDRD
FMETLNTLKY ANRARNIKNR CVVNQDLTSR TIHQLRQEVA RLQVELAEYK QGKRVVSENG
EEGWSDVVQE NAILTSEVES LRRRVKAMQG TIEQLSARNS ELVAEKALGT WAPRDSSPDA
TDCSLTTLVQ GYVTEIEDLR AQLMEATALY EASRKREART RHDSQQDPAS ILDDAKRELY
KEKELLARSM GELEFQRKLA TQVSESGEAR EREGREVTAE GEGEENGQPI GERERAEGES
AGDSDPSDHD DEDRSDDERD EEIEAETAGQ RMLTMQLAAL SEDIDTKARL IEQLEASQRR
LAALRAHYEH RLDTLHHQIK ATGEERDKVL ATLAAQASPP SEKLKRVKEE YERRVSGMAR
ELRRLQAAQR EHARLQRAQA ATAHQIHSLR NDLLNLKRDK VKLVQRMRTE AKRHAQAEAV
RAKEVAQLRK ESRKNANLIR SLEAETRLKE QVLKRKQEEV SLLRRGHRDK LSSKAAGRVH
DGTRSRSRIS SREAWARIEC WVSRASAARA TLAELEATLE AQLRQRDRAA ADPAGPDSTA
LLAYLREAIA DTQHQIMQIE EENEETELSR VLEQVRSAEA GRYALQRLAA LALTHAHDAA
RTVRLLRDTR AQLAEMEEKN DRLTNALKSS NTNGDQNLNP WGVPPPALAA LLAHVSSGTS
TRSVSPSDSA LLERPPVSGA RESSTAPASP PDDNSNSPFH RNTARRGSVR LRDLGVIGRD
EDPMSQSMVE HTPPRPAPLS RVPSAPGSLR GLTPVNSMSS PMTSRRPPPE SPRPLRRQHS
LAKPASLRGS VRLRDLGVIG RDEDPMSQSM VEHTPPRPAP LSRVPSAPGS LRGLTPVNSV
SSPLTSRRPP PESPRPLRRQ HSLAKPASLE TSACAGAGPG ALATPPASPG AARRARDDDV
FLRLAGAAHD NSPQGVVREL PLKQRVSIGA GGGGGGGSGA WLQCTHVAEG HVGAALCLAA
THSLLYSGGV DRTVRGWDLT AGREAWRGGC GAAVAALAAP GLLLAAAGPA VRAFDTRLGT
PVATLWYSVM NAHKGWVTGV CGAGAGRVAS VGRDQTLRLW SPALRPAAHP APLPDAPHAL
APYRSTALCT AARNPSKWIF QGISGTARRI LMKFGTVMVA FVSGKCGKAG DSATSPPARA
APGGDLRTPD TTHRRGTYTY SIVGVARTRT QLWAWHVPVL NCGRGTYPYQ LWAWHVHVLE
CERGTYPYSN VGVARTRTQM WS
//
