ID A0A0N1P250_9EURO Unreviewed; 975 AA.
AC A0A0N1P250;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 09-DEC-2015, sequence version 1.
DT 22-FEB-2023, entry version 27.
DE SubName: Full=Rho-GTPase-activating protein 8 {ECO:0000313|EMBL:KPI45944.1};
GN ORFNames=AB675_796 {ECO:0000313|EMBL:KPI45944.1};
OS Phialophora attinorum.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Chaetothyriomycetidae; Chaetothyriales; Herpotrichiellaceae; Phialophora.
OX NCBI_TaxID=1664694 {ECO:0000313|EMBL:KPI45944.1, ECO:0000313|Proteomes:UP000038010};
RN [1] {ECO:0000313|EMBL:KPI45944.1, ECO:0000313|Proteomes:UP000038010}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 131958 {ECO:0000313|EMBL:KPI45944.1,
RC ECO:0000313|Proteomes:UP000038010};
RA Moreno L.F., Stielow B.J., de Hoog S., Vicente V.A., Weiss V.A.,
RA de Vries M., Cruz L.M., Souza E.M.;
RT "Draft genome of the ant-associated black yeast Phialophora attae CBS
RT 131958.";
RL Submitted (JUN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KPI45944.1}.
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DR EMBL; LFJN01000001; KPI45944.1; -; Genomic_DNA.
DR RefSeq; XP_018005907.1; XM_018148377.1.
DR AlphaFoldDB; A0A0N1P250; -.
DR STRING; 1664694.A0A0N1P250; -.
DR GeneID; 28740246; -.
DR OrthoDB; 1328399at2759; -.
DR Proteomes; UP000038010; Unassembled WGS sequence.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProt.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd04399; RhoGAP_fRGD2; 1.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 2.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR000591; DEP_dom.
DR InterPro; IPR031160; F_BAR.
DR InterPro; IPR001060; FCH_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR23065; PROLINE-SERINE-THREONINE PHOSPHATASE INTERACTING PROTEIN 1; 1.
DR PANTHER; PTHR23065:SF17; RHO-GTPASE-ACTIVATING PROTEIN RGD2; 1.
DR Pfam; PF00610; DEP; 1.
DR Pfam; PF00611; FCH; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00055; FCH; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50186; DEP; 1.
DR PROSITE; PS51741; F_BAR; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|PROSITE-ProRule:PRU01077, ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000038010}.
FT DOMAIN 17..447
FT /note="F-BAR"
FT /evidence="ECO:0000259|PROSITE:PS51741"
FT DOMAIN 244..313
FT /note="DEP"
FT /evidence="ECO:0000259|PROSITE:PS50186"
FT DOMAIN 481..701
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 178..201
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 711..808
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 826..975
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 360..387
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 732..757
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 793..808
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 843..873
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 899..923
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 945..966
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 975 AA; 106526 MW; 462B23E338C786FF CRC64;
MAASETTAPV AKKPKTVGFV DSFWSADYAG GLGILFQKLQ QGVIENTQVL TIATMRADAE
ELYSERLEDI APTIDRMTNG FARDDGASVK KAYEGVRGEM VEAAKNHHKI SNNIRELVVY
PFGRWCDAHA LRVQNSQDDL QSKIKAHDSQ ADLVKKLRSQ YFNKCRLVED QEEENKLAFK
EPEKTELGSP KQSPPPKIIL PDEDEELPVE LGDETFTPER MKEALTAMLN TIPISEFKVP
VLGTYQNVSA GTDIVDFLQK HLGASSVGYA EKMGQDLVDR GFLRLIGSVG STFANSSRMR
YQWKTKVFKI TGIPEKKKPL GRVSSGGSDT GSIDSPVANI TETLQAWNPL NNPYPNMTPS
ERLRREAKDA DEKYKAAIRR LDLLRCNLEE SMMDHLKFLE RCETDRLKAI KSVILDFSGA
ISNSIPSFQS QVDNMVLYQE TINPLSDLRY FLENYRVGAF VPRPTPYENY YGSVDDQIFG
VDLEARARAD RKRVPVLVTS ILTFLDNHYP DLEGDEARRS IWLVDVPLAA THHLRNQLNH
HNQTPENGSS SSSANKIPRE VLERYEIPIV ASVLKLYLLE LPDSLVSSQV YEIIKTIYAT
TSDATPNPIS SDSVDSAPRI KVLQSTLGQL RLNNIATLDA ITTHFTRLID LTSADDAYVG
ELAHVLAPCI LRPRTENTLT LEDRHAYRLV RDLFEHKEAI FGELKRQSST LSASNSIGGR
TRAASKYGAR AKAISEARRD RSPAPTNRHR RDKSTDGSIS AGRFPVVASP RPDQSTFAHR
DAGARVSLPN KRTSLEVPGS LDSSPVQNRN ADAHNKLAAI TQGQPSVAAG NAGGPASAAP
KVDTANGTPT ATTASGLTDS PSALNTPTSL KMNMSAFGGP GPHIPPPVSD DELSDHASSP
QQRKAALANN QAAFGQNAQV GGGSLKRSAA GSGKSAPLAR GRQGTRQGTA DSIGGQSAQQ
QGVSLSDKPF DDDFS
//
