ID A0A0N1PBB8_LEPSE Unreviewed; 4663 AA.
AC A0A0N1PBB8;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 09-DEC-2015, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE SubName: Full=Putative dynein heavy chain {ECO:0000313|EMBL:KPI86104.1};
GN ORFNames=ABL78_4831 {ECO:0000313|EMBL:KPI86104.1};
OS Leptomonas seymouri.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leptomonas.
OX NCBI_TaxID=5684 {ECO:0000313|EMBL:KPI86104.1, ECO:0000313|Proteomes:UP000038009};
RN [1] {ECO:0000313|EMBL:KPI86104.1, ECO:0000313|Proteomes:UP000038009}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 30220 {ECO:0000313|EMBL:KPI86104.1,
RC ECO:0000313|Proteomes:UP000038009};
RX PubMed=26317207;
RA Kraeva N., Butenko A., Hlavacova J., Kostygov A., Myskova J., Grybchuk D.,
RA Lestinova T., Votypka J., Volf P., Opperdoes F., Flegontov P., Lukes J.,
RA Yurchenko V.;
RT "Leptomonas seymouri: Adaptations to the Dixenous Life Cycle Analyzed by
RT Genome Sequencing, Transcriptome Profiling and Co-infection with Leishmania
RT donovani.";
RL PLoS Pathog. 11:E1005127-E1005127(2015).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KPI86104.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; LJSK01000148; KPI86104.1; -; Genomic_DNA.
DR EnsemblProtists; KPI86104; KPI86104; ABL78_4831.
DR VEuPathDB; TriTrypDB:Lsey_0148_0060; -.
DR OMA; ICEHMAY; -.
DR OrthoDB; 166463at2759; -.
DR Proteomes; UP000038009; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR Gene3D; 1.10.287.2620; -; 1.
DR Gene3D; 1.10.472.130; -; 1.
DR Gene3D; 1.10.8.1220; -; 1.
DR Gene3D; 1.10.8.710; -; 1.
DR Gene3D; 1.20.1270.280; -; 1.
DR Gene3D; 1.20.58.1120; -; 1.
DR Gene3D; 1.20.920.20; -; 1.
DR Gene3D; 1.20.920.30; -; 1.
DR Gene3D; 3.10.490.20; -; 1.
DR Gene3D; 6.10.140.1060; -; 1.
DR Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 5.
DR Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR035706; AAA_9.
DR InterPro; IPR041658; AAA_lid_11.
DR InterPro; IPR042219; AAA_lid_11_sf.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR041589; DNAH3_AAA_lid_1.
DR InterPro; IPR042222; Dynein_2_N.
DR InterPro; IPR043157; Dynein_AAA1S.
DR InterPro; IPR041466; Dynein_AAA5_ext.
DR InterPro; IPR041228; Dynein_C.
DR InterPro; IPR043160; Dynein_C_barrel.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR InterPro; IPR013602; Dynein_heavy_linker.
DR InterPro; IPR013594; Dynein_heavy_tail.
DR InterPro; IPR042228; Dynein_linker_3.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR10676:SF36; DYNEIN HEAVY CHAIN AT 93AB, ISOFORM C; 1.
DR PANTHER; PTHR10676; DYNEIN HEAVY CHAIN FAMILY PROTEIN; 1.
DR Pfam; PF12774; AAA_6; 1.
DR Pfam; PF12775; AAA_7; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF12781; AAA_9; 1.
DR Pfam; PF17857; AAA_lid_1; 1.
DR Pfam; PF18198; AAA_lid_11; 1.
DR Pfam; PF08385; DHC_N1; 1.
DR Pfam; PF08393; DHC_N2; 1.
DR Pfam; PF17852; Dynein_AAA_lid; 1.
DR Pfam; PF18199; Dynein_C; 1.
DR Pfam; PF03028; Dynein_heavy; 1.
DR Pfam; PF12777; MT; 1.
DR SMART; SM00382; AAA; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Dynein {ECO:0000256|ARBA:ARBA00023017};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741}.
FT DOMAIN 1915..2014
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2542..2695
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT REGION 4084..4141
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 3150..3177
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3365..3406
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 4111..4125
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 4663 AA; 530296 MW; B2B916497B0FDD09 CRC64;
MGKNDKDEAP TDKRVLWMEQ RIMNAIKLKP VESKKLIENE ENRAQLSEFL DTADARHLYV
YQAPNGAFVT RIEAPEELKK KGVFFSKLKR EKITDDNHMK EAVIFGDVSP DTLGSLSVMT
RNVYAPILKA DKRNTSSVPD VAVSELMSDT NGLLSQLLVT LGLSQGKTFL PMPPIQFPPR
IDDFAMDKET LYLLEGTVVS WTAQIKAAIA SSPEELEELI PPTGRYPCPL DEIRFWKEKS
ENLAGLEEQL YSVKSLKVLV LLKRAGSSYY APFSQLMGEL KDAAYESRDN YQFLKPLIPE
FEKMCLSGDH LPFPELATSG LFKRLFHFLY LLWTQSGFYN NPARLVFLIR EMGNDLMEMA
ADHISVAEFA EGFEKKEAIE RLSTALAICG EFKASYFQYK SHVSSVARPW KFQNAALFSR
LDAFLERCHD VLDVIETALL FDKMENMRIG GTKGQSLTVE AEEIKHTFDA AVARFFSVEY
NLLDVTNLRF EADYDELKMV IRDLEERLGS ILVTTIDDSS AIAEVFKAVD TFDGFTERTP
MQQEWLKKQS GVLNDFHQDL LTSQETYYSG EAAGAYPNMP PVASTIVRCK ALLDRINESH
NRVMDLAPTV LQSERGVEAL QLYEKLKERL QNTITEKFQK WTMEVSGIRT DKLRLPVLTT
DSNDHIAVNF DASLVKTLRE VYYVELLNSY DASGVGHFEI PPDAEAIFAK RDVYRDQALK
LEYICTTFNN LSSSLRPDDE RPLIEDELQK FEAYVSHGLK EIRWENEEAT DAFIEEALKQ
VTAIDTAVST LHSNVQQLKD SMKRYRDEDE LFPLDSAKGA KTMSELELRK TLSEYAESRA
AGLRERNGEI QSLTENSFAA LQTLKETSGA AGVSASDPVW HRYLSYVSSV VQDCLAEAAV
AFLTNLRNQL DSVWLADNDG IPLVDVKLCL SKVTVENPVC KSHFEPALTS VEEDGKSVWQ
ILSDTIEGVI SSSALIDPIY GTVPYTEELR HNEGVHNLVE EIRHLFQQNV AACEEYLHVY
DEFKSLWETD RKKVFAQFID MERRRDSRVS MSMDDGATVH TGANTQDPAE YFGVSLQEFD
RAITEYTRIR TRLSSIEDRH REGAVLVDVK PLRVALRDLS RRWKEIYSDY LLDKIKADLN
HLYTFMKEAD KGLEVEVLDG DIDALKSVMR WIRDCRKRNT EVMGEDESGE TSGMFPPIKA
AISMLKTHAS TSPDAEAELA KIEKLEELRK PAPEQWVALN KKALNARAQN SIVQDREAEK
VKEDVASFEH ELAAEVEAFH KNPLFTYAIQ PGEVYETIDT VYLHFMNVER KAKELQNLQD
LFDLAMSHFK SIRECRQELA LLRQIWDLNF HVTSQFRDWM RSTFKDADVA HFEDEAKKMA
KQLQQQPMKV KGWGVFKGVD ETVRNMRTSL PLCDSLSSPA MRQRHWEELV RTTNQPGTIN
PGAADFTLEK LFALGLHNYA EEVANIVEKA EKELRIETNL RKIVEAWDKL RFTYERDTHL
DCYLLGPVDD VVEQLENDNN ALSSMLSDRF VEYFYEKVLA WQKDLGLVDA CTTKWIDIQR
QWQNLFPIFV LSEDIKVQLP EEAKKFSEAD RVFRLLMSKA HPYTSPVEVI CSNKLSDDIG
RSETLEETLN YIQDILNQCE KALADYLEMK RKLFPRFFFV SDTDLIDILS KGSDPRAVME
HMSKIMDSVD TFIFDENPHP CAGEKDVWQM VSIQGEKVTL AESFNCDGAV EVWLDELVQS
VQQSMKVHIR EANAGYIEKP RNEWIYQYPC QAVIVASRIW FTTEVHQAFT QIEEGNDMGM
KDLLKSQKLQ LDSLIKEVLL DRRSTERKML VHLITIDVHN RDIVQSMVDD RIDSVESFSW
QSQLRYYWDE VKGSEIRIAD ADFINGYEYI GLCGCLVITK LTDRCYITLT QALRLNQGGA
PAGPAGTGKT ETTKDLARNM GVACYVFNCS DQMNYITLGQ IFKGLAMSGS WGCFDEFNRI
SIEVLSVVAT QVGSILNALK ENKSRFRFMD EEISIKRSVG TWITMNPGYA GRTELPENIK
SLFRPCAMCV PDLKNICEIM LAAEGFGDAK DLALKFVTLY RLNKELLSPQ DHYDWGLRAV
KSVLYIAGAL KRGDPDLPER NVLMRALRDT NMAKLSKDDV YVFMGLIRSL FPNLDVPKKD
KPELVAACKA VCKEQGNLPG ENDIFILKCV QYEELLHVRH SVFILGAAGS GKTECWRCLQ
GALTKLHQDE WKAKAVSSCL NPKAISSNEL YGYFTPQKEW RDGILSTIFR DYAVESKKKK
NMKWIVLDGI IDAEWIESMN TVMDDNKMLT LVSNERIPLT DSMRMIFEVS HLRNASPATV
SRAGVIFINE SDLGWGPFKD KWIATRERRE GIILDNLFDK YVPAVFDFWK RMVRPIVALM
DINIVQTVCF LLDGIFKTMD PEELAKHSNA SDVYEKYFAF AVIWAFGGPL PSSDGRIDMR
LNFSNQWKKE FPNMKISETG SIFDFYIEKT KDEAGTLVFD WKPWTELVQP YTPEPEVQLS
TVSVQTADTV RMSYLMSLFI DNARGVVLVG TAGTGKTNLI MSKLRSLDSE KVLFRVVSFN
ARTSSSGLQA VMEQSLEKRS GRTYGPPNRK KLVFFLDDMN MPAPDKYGTQ EAIALLQQHV
GYGFWYDRVK IVQKEVVDVR YVGAMNPKSG TFTVLDRLLR HFAVFSTNMP ERADLVSIYG
QILRAHTKPF TRDIRETLTT LLTNATIELH ASVAKLFFPT AIKFHYQWNM REMFNIFQGL
CKSNPKLHNT SLQFVRLWVH ECNRTFRDRM GDEADMKRFD ALLQEVIGRA GFTDVSVKEA
LEEPLLWAPF HTTPNGEENV YHATSYDEAG VFLRRKLEEY NENYAAMNLV LFNQAIEHVC
RISRITSNPR GNAFLVGVGG SGKQSLARLA SYINGHDIFQ IFVTSTYDIN DFRTDMQELY
RKCGLRGYPF AFIITDTQIV SMDMLVYLND MLSSGNVPEL FNQDEREGIV GSITNEVKAA
GIGDYTNPDV CWEYFIHKVR SNLHILLCFS PVGKNFAKWC RQFPALANTT VIDWFLSWPE
QALRSVAQRF LSEIDLGGEA MTESIADFMA YCQIRVTESC EEYYTQEKRY AYTTPKSFLE
LIAFYKDLLA RKRKENSDQT ERLVSGIGKI QEAGAQVQAL QEVLQRESVE VEEAREKTVA
LMETVGREKS IVEEQSAIAA KEEAKTNKIV DEVTSFERQC QEDLAKAQPL VQEALAALDT
LDKASIAELK NLGKPPEDVQ MVAICVLVLT SNPRSIPSMK QRSWNECKKM MNQVDRFLAE
LRGFDVNNIP QPCIDQIQVY INNPSFDPEI IRNKSFAAAG LCKWAIGMNR YHCVRCEVRP
KEERLAEAQQ RLASSRAALK KIQDKVADLK SKLDTLVSQY DEAVAESNAI EAKARKTQLK
MNLAQRLVSG LSDESVRWGD TIEKLKEAAK LLIGDVLLSA SFVSYIGPFS KAFREQIVEQ
DWIPYIRKLG IPMTEGIDAT MDVLTSEAAV ASWNNEGLPS DRVSTENGAI LNNCMRWPLL
IDPQLQGIKW IRTREEKNGL RVVQTSQKGW QRTLQTCIEE GLPCLIESLG EFVEPVLDGV
LSRQTFRKGG REYIKLGATE VLYNPKFRLI LQTKLGNPRY GPEVNAQTTL INFMVTEAGL
EDQLLAVVVS QERPDLEKKR GMLIRQMNTM TIELQECENG LLFELTNATG DILENVTLIE
NLETTKKKAK EINASYAQAV VTQNDIAQNR LRYTEVAVRG SLLFFQIDQL WKIDHMYQYS
LEAFMVVFNK ALASAPHPEN KKDVTKRVTN VIQSITENVF AYVSRGLFER HKLIFSSLLT
FSILSRRGEI DAKQLDFLLR GKKKTGVERP ETVVGWCTQP NWDAVQALAE IDGATPEFNV
LPSDMAENNR WFQYCELEKP EVEKMPGEWK NLTDFQRLLV LRCLRPDRLT AALEMYVSNS
IGRFFVSDQA VEISVSYQNS STTTPLFFIL SPGVDPVKAV EELGRKLGYT YDKENFYNVS
LGQGQEVVAD RALDKCFAEG GWALLSNIHL VERWLRSLER RLDTYAETYT RVAQLRKEIA
ERKAGERAAA AGESAEHPPE GNDEGGAEGD DAAEDSKMLH SPEDGEGGET DEDASVEEGG
GAGAADAIVV TDDEIPFEGV KGHPDFRVFL SAEPSTVIPI GILQRSVKLT SEPPTGIRQN
IVRAMNNFSD EPWERSAKPT EYRCIMFSMC FFHAVVVERK KFGPLGWNRA YPFNAGDLTT
CMEVAANYIE DRPKVPWEDL RYVFGEIMYG GHITDDWDRV LCMAYLKSYI IPDCCDGLQL
APGVQVPAPA SYQEYMQWLT VSDDFPAESP LLYGLHPNAE INYRTTQAEV LFRTINELQP
KKHSGGDMLS PQEIVQQKID EIRERLPEPH NLLDLAERLE EDRSPQQHVF YQESERMNLL
IETLSTSLEE LDLGLKGALS MSSSMQELFD QIFLDKMPEK WARVSFMSQR MLGSWVDNFL
ARNEQLLNWN AELQTPKVTN IALFFNPMSF LTAIMQTTSI INSFDLDQMS LVVDVLKKSV
DQIESNARDG CYVTGLSMEG ARWDASGGCI EDSRLKELYP KMPIMQVRSL PLSKIDYRDQ
YECPVYKTQE RGPGFVVGFH LKTKQPPRKW VIAGVGLLLD VVE
//
