ID A0A0N1PBL6_LEPSE Unreviewed; 388 AA.
AC A0A0N1PBL6;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 09-DEC-2015, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE SubName: Full=ATP-dependent phosphofructokinase {ECO:0000313|EMBL:KPI82480.1};
DE Flags: Fragment;
GN ORFNames=ABL78_8510 {ECO:0000313|EMBL:KPI82480.1};
OS Leptomonas seymouri.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leptomonas.
OX NCBI_TaxID=5684 {ECO:0000313|EMBL:KPI82480.1, ECO:0000313|Proteomes:UP000038009};
RN [1] {ECO:0000313|EMBL:KPI82480.1, ECO:0000313|Proteomes:UP000038009}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 30220 {ECO:0000313|EMBL:KPI82480.1,
RC ECO:0000313|Proteomes:UP000038009};
RX PubMed=26317207;
RA Kraeva N., Butenko A., Hlavacova J., Kostygov A., Myskova J., Grybchuk D.,
RA Lestinova T., Votypka J., Volf P., Opperdoes F., Flegontov P., Lukes J.,
RA Yurchenko V.;
RT "Leptomonas seymouri: Adaptations to the Dixenous Life Cycle Analyzed by
RT Genome Sequencing, Transcriptome Profiling and Co-infection with Leishmania
RT donovani.";
RL PLoS Pathog. 11:E1005127-E1005127(2015).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + beta-D-fructose 6-phosphate = ADP + beta-D-fructose 1,6-
CC bisphosphate + H(+); Xref=Rhea:RHEA:16109, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:32966, ChEBI:CHEBI:57634,
CC ChEBI:CHEBI:456216; EC=2.7.1.11;
CC Evidence={ECO:0000256|ARBA:ARBA00000432};
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KPI82480.1}.
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DR EMBL; LJSK01000914; KPI82480.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0N1PBL6; -.
DR EnsemblProtists; KPI82480; KPI82480; ABL78_8510.
DR VEuPathDB; TriTrypDB:Lsey_0916_0010; -.
DR UniPathway; UPA00109; UER00182.
DR Proteomes; UP000038009; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR GO; GO:0003872; F:6-phosphofructokinase activity; IEA:UniProtKB-EC.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006002; P:fructose 6-phosphate metabolic process; IEA:InterPro.
DR Gene3D; 3.40.50.450; -; 2.
DR InterPro; IPR022953; ATP_PFK.
DR InterPro; IPR000023; Phosphofructokinase_dom.
DR InterPro; IPR035966; PKF_sf.
DR InterPro; IPR012004; PyroP-dep_PFK_TP0108.
DR PANTHER; PTHR45770; ATP-DEPENDENT 6-PHOSPHOFRUCTOKINASE 1; 1.
DR PANTHER; PTHR45770:SF11; ATP-DEPENDENT 6-PHOSPHOFRUCTOKINASE 1; 1.
DR Pfam; PF00365; PFK; 1.
DR PIRSF; PIRSF000534; PPi_PFK_TP0108; 1.
DR PRINTS; PR00476; PHFRCTKINASE.
DR SUPFAM; SSF53784; Phosphofructokinase; 1.
PE 4: Predicted;
KW Glycolysis {ECO:0000256|ARBA:ARBA00023152};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:KPI82480.1};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 41..345
FT /note="Phosphofructokinase"
FT /evidence="ECO:0000259|Pfam:PF00365"
FT NON_TER 388
FT /evidence="ECO:0000313|EMBL:KPI82480.1"
SQ SEQUENCE 388 AA; 42283 MW; E2F2479B239D3385 CRC64;
MYDPRPQKGL DTEYPVSCNK LVCELAAARK QLHFNPSETT IGIVTCGGIC PGLNDVIRSI
TLAATMAYHV KRVVGFRYGY WGLSKEGSKT AIELTRNEVR QIHRFGGTIL GSSRGPQSSK
EMVDTLVRMK INILFTVGGD GTQRGALTIY EEAKRRGENI AVFGVPKTID NDLAFSHRTF
GFQTAVEQAV IAVRAAYAEA VSLNWGVGIV KLMGRESGFI AAETAVASAQ ANICLIPENP
LPKETVLRLI ERRFQQSRNC VIIVAEGFGQ DWESGSGGHD ASGNKKLVDI GMILKSEVEK
WLKANKEKYP SGTVKYIDPS YMVRACAPTS NDALFCASLA TLAVHEAMSG ATGCVIAMRY
NNYIVVPIKA ATSVRRVVSL RGALWRQV
//
