ID   A0A0N1PDK7_LEPSE        Unreviewed;      1082 AA.
AC   A0A0N1PDK7;
DT   09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT   09-DEC-2015, sequence version 1.
DT   27-MAR-2024, entry version 15.
DE   RecName: Full=Serine aminopeptidase S33 domain-containing protein {ECO:0000259|Pfam:PF12146};
GN   ORFNames=ABL78_3737 {ECO:0000313|EMBL:KPI87175.1};
OS   Leptomonas seymouri.
OC   Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC   Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leptomonas.
OX   NCBI_TaxID=5684 {ECO:0000313|EMBL:KPI87175.1, ECO:0000313|Proteomes:UP000038009};
RN   [1] {ECO:0000313|EMBL:KPI87175.1, ECO:0000313|Proteomes:UP000038009}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 30220 {ECO:0000313|EMBL:KPI87175.1,
RC   ECO:0000313|Proteomes:UP000038009};
RX   PubMed=26317207;
RA   Kraeva N., Butenko A., Hlavacova J., Kostygov A., Myskova J., Grybchuk D.,
RA   Lestinova T., Votypka J., Volf P., Opperdoes F., Flegontov P., Lukes J.,
RA   Yurchenko V.;
RT   "Leptomonas seymouri: Adaptations to the Dixenous Life Cycle Analyzed by
RT   Genome Sequencing, Transcriptome Profiling and Co-infection with Leishmania
RT   donovani.";
RL   PLoS Pathog. 11:E1005127-E1005127(2015).
CC   -!- SIMILARITY: Belongs to the AB hydrolase superfamily. AB hydrolase 4
CC       family. {ECO:0000256|ARBA:ARBA00010884}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KPI87175.1}.
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DR   EMBL; LJSK01000099; KPI87175.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0N1PDK7; -.
DR   EnsemblProtists; KPI87175; KPI87175; ABL78_3737.
DR   VEuPathDB; TriTrypDB:Lsey_0099_0080; -.
DR   OMA; HEHTSRV; -.
DR   OrthoDB; 1655372at2759; -.
DR   Proteomes; UP000038009; Unassembled WGS sequence.
DR   Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR022742; Hydrolase_4.
DR   PANTHER; PTHR10794; ABHYDROLASE DOMAIN-CONTAINING PROTEIN; 1.
DR   PANTHER; PTHR10794:SF63; ALPHA_BETA HYDROLASE 1, ISOFORM A; 1.
DR   Pfam; PF12146; Hydrolase_4; 1.
DR   SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
PE   3: Inferred from homology;
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           20..1082
FT                   /note="Serine aminopeptidase S33 domain-containing protein"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5005879712"
FT   DOMAIN          429..585
FT                   /note="Serine aminopeptidase S33"
FT                   /evidence="ECO:0000259|Pfam:PF12146"
FT   REGION          167..201
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          358..410
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          729..759
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          877..946
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        167..198
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        380..410
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        910..924
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1082 AA;  117178 MW;  0B35821EF7A532B0 CRC64;
     MKLYSVAFFI LHCILHVFCY WIPRSVGACV DLLLCRPCRT SEKRRHGYSY HPAREVRLIH
     NAEYTEAAVK VFGLMDVRAS TLEDRQYCFS TVSGANEKNE ARKARSAPLT PIPLRDAGCA
     STSAFAGEDV DPSASATAAR THHGNAASYS PLEPSFAFSA APSVDGTYNS QRHPRLSSSF
     SHPPREQITA TTPAATTSVP PAPAAKKALH IPTYKSPSKA FKKDIKRCSL KYSAPLYGPH
     LSTIMGAYRP THPVQYTREE MCAWDGCYLA MDWFYVAGEA PTTYDHEHTS RVRKAGERCD
     RAANEPFSGV QGEAAVPSSA AEEGCRVDNA HRDRASATHA SSGAACVDEM FSIAPATTEA
     EKGGVRGVAS GRQRATEDAP LETSRNSLPT YTTSDGTVGP NSNSGSSRPD IQKLAETPIL
     ATTHYNAVGV AFIVPGLTSS SQTNYVQHLV RALHKANLHV CVLNTRGLGD SPPITTPFLF
     NGAYTRDVRD CLHHFFAKEA LADRFGRPLP LIGIGLSIGG TIMAKYVGEE GAAGADPHLD
     ALICVCPPVD YVMTVEHMNR NGAQRALYQR DMCNSIRRYL LQHDPLQRMP KVDNDWVFVQ
     GNIHRFRRVL HFDEHVIAKS SGYRSVHHYH VDASALTWLP YAPIPALVMA SADDPVIGCT
     VMPHRWREIT CNNPRVVYVE SSTGGHLGFL SDPWSELMCN DNWMEIFVRD RVLAACDYWY
     AVQRRAKDLK PSSGGEGSRG SAASNVEAHP PPLSLPATVD SPVTNVAVTA SAPSAVTPET
     LSYPSWSMMR VVPEVCAQNR ATVGKGCYLE GSDSSASAAI YRARQHDRRG QEQPAALANG
     FDAATHGGVA VSSTDEGQMA YSDRGCSTYL VASTELPASR DHADGRDASS THEPIQDASA
     AAAHLAMREH RSSLSSSPQV ATEKDTANPP PCKSLAPATA GSASPQPIPC GLPHQGRPNN
     WCYFTSFRTQ PVPRSRLMQP YFAPPSGTTY DGERSEVNDT VFKSTASSGD ERGSTYVTWP
     DVNGACGGRR SACHDQNQRG EGGILAMGKD PRCRVTAGQY MYAPVVVNCD YAGDPRTWMG
     DG
//