ID A0A0N1PG13_PAPXU Unreviewed; 908 AA.
AC A0A0N1PG13;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 09-DEC-2015, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=Glutamate receptor, ionotropic kainate 2 {ECO:0000313|EMBL:KPJ04257.1};
DE Flags: Fragment;
GN ORFNames=RR46_01541 {ECO:0000313|EMBL:KPJ04257.1};
OS Papilio xuthus (Asian swallowtail butterfly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Papilionoidea;
OC Papilionidae; Papilioninae; Papilio.
OX NCBI_TaxID=66420 {ECO:0000313|EMBL:KPJ04257.1, ECO:0000313|Proteomes:UP000053268};
RN [1] {ECO:0000313|EMBL:KPJ04257.1, ECO:0000313|Proteomes:UP000053268}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Ya'a_city_454_Px {ECO:0000313|EMBL:KPJ04257.1};
RC TISSUE=Whole body {ECO:0000313|EMBL:KPJ04257.1};
RX PubMed=26354079; DOI=10.1038/ncomms9212;
RA Li X., Fan D., Zhang W., Liu G., Zhang L., Zhao L., Fang X., Chen L.,
RA Dong Y., Chen Y., Ding Y., Zhao R., Feng M., Zhu Y., Feng Y., Jiang X.,
RA Zhu D., Xiang H., Feng X., Li S., Wang J., Zhang G., Kronforst M.R.,
RA Wang W.;
RT "Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.";
RL Nat. Commun. 6:8212-8212(2015).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the glutamate-gated ion channel (TC 1.A.10.1)
CC family. {ECO:0000256|ARBA:ARBA00008685}.
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DR EMBL; KQ459037; KPJ04257.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0N1PG13; -.
DR STRING; 66420.A0A0N1PG13; -.
DR Proteomes; UP000053268; Unassembled WGS sequence.
DR GO; GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-KW.
DR GO; GO:0015276; F:ligand-gated monoatomic ion channel activity; IEA:InterPro.
DR GO; GO:0038023; F:signaling receptor activity; IEA:InterPro.
DR GO; GO:0007154; P:cell communication; IEA:UniProt.
DR CDD; cd06382; PBP1_iGluR_Kainate; 1.
DR CDD; cd13714; PBP2_iGluR_Kainate; 1.
DR Gene3D; 3.40.50.2300; -; 2.
DR Gene3D; 3.40.190.10; Periplasmic binding protein-like II; 3.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR019594; Glu/Gly-bd.
DR InterPro; IPR001508; Iono_Glu_rcpt_met.
DR InterPro; IPR015683; Ionotropic_Glu_rcpt.
DR InterPro; IPR001320; Iontro_rcpt_C.
DR InterPro; IPR028082; Peripla_BP_I.
DR PANTHER; PTHR18966:SF591; CLUMSY, ISOFORM B-RELATED; 1.
DR PANTHER; PTHR18966; IONOTROPIC GLUTAMATE RECEPTOR; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR Pfam; PF00060; Lig_chan; 1.
DR Pfam; PF10613; Lig_chan-Glu_bd; 1.
DR PRINTS; PR00177; NMDARECEPTOR.
DR SMART; SM00918; Lig_chan-Glu_bd; 1.
DR SMART; SM00079; PBPe; 1.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR SUPFAM; SSF53850; Periplasmic binding protein-like II; 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Ligand-gated ion channel {ECO:0000256|ARBA:ARBA00023286};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Postsynaptic cell membrane {ECO:0000256|ARBA:ARBA00023257};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000313|EMBL:KPJ04257.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000053268};
KW Synapse {ECO:0000256|ARBA:ARBA00023018};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 550..569
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 626..646
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 416..790
FT /note="Ionotropic glutamate receptor C-terminal"
FT /evidence="ECO:0000259|SMART:SM00079"
FT DOMAIN 426..494
FT /note="Ionotropic glutamate receptor L-glutamate and
FT glycine-binding"
FT /evidence="ECO:0000259|SMART:SM00918"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KPJ04257.1"
SQ SEQUENCE 908 AA; 101330 MW; BC201EAB72EB789F CRC64;
VKLCLIYFVV VPKIYAFRKF ESLKTTIPIG VILPPNTLAE VAFASALTRA SVESKRYHFT
MKALNVPEGD SFAASKAACE LLAGGVVAIF GPSDVNSAAV VDARCRAARV PHIQAVWRPS
PARGIKRPTP PGINLYPEAV SLSKAVASHI KDSNWNSYTL FYDDDQGLIR LQEILKHAEP
GHKWFVRRLV PGGDNRPLFK AVKTTGATRV VIDCPAERIL EYLRQANEVK FFEDYMSYVL
MSLDAHTLDL EELRYGLSNV TSMRIVDHSD SRTLSYLADW KTRSAPEVVI PKTTQEITVE
AALASDAATL ITDAFKTAPE GFTIEPQELE CNSESQWEVG EEFLDHLLMN PTFGITDKIV
LDNTTGERTY FNVEIMELSN SGFNSIAKWN SITGYKYARS AVEVSDLLAE KWQNKTFRVV
SRIGAPYLVE KTPKEGEELT GNDRYEGYSK DLIHEILAES LHLNYEIIIV PGNLYGSYNK
ETKTWDGLIG YLLERKADLA ICDLTITYER RSSVDFTTPF MTLGISILYS KPTPPPPELF
SFLKPFSVDV WIYMAAAYLM VSLLLHILAR LAPKDWENPH PCDKSPEELE NIWHIKNSCW
LTVGSIMTQG SDILPKGYST RWVCGMWWFF ALIMCSSYTA NLAAFLTNAA MDDSIKSAED
LASQTKIKYG TVLGGSTYSF FKRSNVSTFQ KMWGTMESTR PSVFVKNNDE GVDRVMKMKK
KYAFLMESTA IEYQLERNCD LMQIGSTLDS KGYGIAMPFD SSYRTAVDNA VLKLAESGKL
VELKNRWWKV PKEKACVAEE AGEEGASAEE LGVDNVGGVF VVLGIGCGMA AAMGGFEFLW
HVREVAIEQK MSQTDAFWAE LAFALSFWET EKPVVHSRPS SSASGSIASR ASSVLRSAVD
LFHLDVFK
//
