ID A0A0N4SWZ4_BRUPA Unreviewed; 481 AA.
AC A0A0N4SWZ4;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 09-DEC-2015, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE RecName: Full=RBR-type E3 ubiquitin transferase {ECO:0000256|ARBA:ARBA00012251};
DE EC=2.3.2.31 {ECO:0000256|ARBA:ARBA00012251};
GN ORFNames=BPAG_LOCUS174 {ECO:0000313|EMBL:VDN81360.1};
OS Brugia pahangi (Filarial nematode worm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Brugia.
OX NCBI_TaxID=6280 {ECO:0000313|Proteomes:UP000038020, ECO:0000313|WBParaSite:BPAG_0000017301-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:BPAG_0000017301-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (FEB-2017) to UniProtKB.
RN [2] {ECO:0000313|EMBL:VDN81360.1, ECO:0000313|Proteomes:UP000278627}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Pathogen Informatics;
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine +
CC [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-
CC cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.;
CC EC=2.3.2.31; Evidence={ECO:0000256|ARBA:ARBA00001798};
CC -!- SIMILARITY: Belongs to the RBR family. Ariadne subfamily.
CC {ECO:0000256|ARBA:ARBA00005884}.
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DR EMBL; UZAD01000007; VDN81360.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0N4SWZ4; -.
DR STRING; 6280.A0A0N4SWZ4; -.
DR WBParaSite; BPAG_0000017301-mRNA-1; BPAG_0000017301-mRNA-1; BPAG_0000017301.
DR Proteomes; UP000038020; Unplaced.
DR Proteomes; UP000278627; Unassembled WGS sequence.
DR GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd20344; BRcat_RBR_TRIAD1; 1.
DR CDD; cd20360; Rcat_RBR_TRIAD1; 1.
DR Gene3D; 1.20.120.1750; -; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR045840; Ariadne.
DR InterPro; IPR048962; ARIH1-like_UBL.
DR InterPro; IPR047555; BRcat_RBR_TRIAD1.
DR InterPro; IPR045093; Cullin.
DR InterPro; IPR002867; IBR_dom.
DR InterPro; IPR047556; Rcat_RBR_TRIAD1.
DR InterPro; IPR044066; TRIAD_supradom.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR22771; CULLIN AND GALACTOSE-BINDING DOMAIN-CONTAINING; 1.
DR PANTHER; PTHR22771:SF3; CULLIN-7; 1.
DR Pfam; PF21235; ARI1_UBAl; 1.
DR Pfam; PF19422; Ariadne; 1.
DR Pfam; PF01485; IBR; 2.
DR SMART; SM00647; IBR; 2.
DR SUPFAM; SSF57850; RING/U-box; 3.
DR PROSITE; PS51873; TRIAD; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000278627};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}.
FT DOMAIN 118..333
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS51873"
FT DOMAIN 122..158
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
SQ SEQUENCE 481 AA; 56198 MW; 3FE132E5753F8104 CRC64;
MECGDAPADS PSFSDDEADY DYDDFYCNGE NCGMEIFERE DPEYIEYACL KVPEVERLLK
ETVDHVVSTL NVSSSLAKIL LHFYKWDDST LIQLYRVDPC KVLVDCFVCA GSSKQQPDTM
SCVVCTRLQD ECTKMYALDC GHSFCSACWM EYIETQLCNG LSITIGCMAS GCTLLCLEDF
VLRILSERTE IRHKYERLIF KDCVESHPQL RFCPGIDCHV VIKAQCQKAK KVTCTSCRIS
FCFVYSFQCG CDYHAPTSCE TIRKWLTKCA DDSETANYIS AHTKDCPNCH SCIEKNGGCN
HMQCAKCKYH FCWMCFGDWK NHGSEYYECS RYKENPSIAQ EANHVKARRA LEKYLHYYER
YENHHKSLKM EENLRNCIMK KIDEKVNGYE GTWIDWQYLH RAATLLTKCR YTLQYTYPYA
YYMENGPRKQ LFEYQQAQLE KEIEELSWKV ERAESTERGD LETQMHVAEC KRRTLLQDFF
D
//
