ID   A0A0N4SXT2_BRUPA        Unreviewed;       763 AA.
AC   A0A0N4SXT2;
DT   09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT   09-DEC-2015, sequence version 1.
DT   27-MAR-2024, entry version 35.
DE   SubName: Full=Arf-GAP domain-containing protein {ECO:0000313|WBParaSite:BPAG_0000050201-mRNA-1};
GN   ORFNames=BPAG_LOCUS503 {ECO:0000313|EMBL:VDN81689.1};
OS   Brugia pahangi (Filarial nematode worm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Brugia.
OX   NCBI_TaxID=6280 {ECO:0000313|Proteomes:UP000038020, ECO:0000313|WBParaSite:BPAG_0000050201-mRNA-1};
RN   [1] {ECO:0000313|WBParaSite:BPAG_0000050201-mRNA-1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (FEB-2017) to UniProtKB.
RN   [2] {ECO:0000313|EMBL:VDN81689.1, ECO:0000313|Proteomes:UP000278627}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Pathogen Informatics;
RL   Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; UZAD01000023; VDN81689.1; -; Genomic_DNA.
DR   STRING; 6280.A0A0N4SXT2; -.
DR   WBParaSite; BPAG_0000050201-mRNA-1; BPAG_0000050201-mRNA-1; BPAG_0000050201.
DR   Proteomes; UP000038020; Unplaced.
DR   Proteomes; UP000278627; Unassembled WGS sequence.
DR   GO; GO:0005096; F:GTPase activator activity; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0007420; P:brain development; IEA:InterPro.
DR   GO; GO:0032012; P:regulation of ARF protein signal transduction; IEA:InterPro.
DR   CDD; cd08833; ArfGap_GIT; 1.
DR   Gene3D; 1.20.5.170; -; 1.
DR   Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR   Gene3D; 1.10.220.150; Arf GTPase activating protein; 1.
DR   Gene3D; 1.20.120.330; Nucleotidyltransferases domain 2; 1.
DR   InterPro; IPR002110; Ankyrin_rpt.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   InterPro; IPR037278; ARFGAP/RecO.
DR   InterPro; IPR001164; ArfGAP_dom.
DR   InterPro; IPR038508; ArfGAP_dom_sf.
DR   InterPro; IPR047161; GIT-like.
DR   InterPro; IPR032352; GIT1/2_CC.
DR   InterPro; IPR022018; GIT1_C.
DR   InterPro; IPR013724; GIT_SHD.
DR   PANTHER; PTHR46097:SF3; ARF GTPASE-ACTIVATING PROTEIN GIT; 1.
DR   PANTHER; PTHR46097; G PROTEIN-COUPLED RECEPTOR KINASE INTERACTING ARFGAP; 1.
DR   Pfam; PF00023; Ank; 1.
DR   Pfam; PF01412; ArfGap; 1.
DR   Pfam; PF12205; GIT1_C; 1.
DR   Pfam; PF16559; GIT_CC; 1.
DR   Pfam; PF08518; GIT_SHD; 1.
DR   PRINTS; PR00405; REVINTRACTNG.
DR   SMART; SM00105; ArfGap; 1.
DR   SMART; SM00555; GIT; 2.
DR   SUPFAM; SSF48403; Ankyrin repeat; 1.
DR   SUPFAM; SSF57863; ArfGap/RecO-like zinc finger; 1.
DR   PROSITE; PS50115; ARFGAP; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Reference proteome {ECO:0000313|Proteomes:UP000278627};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833};
KW   Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00288}.
FT   DOMAIN          1..134
FT                   /note="Arf-GAP"
FT                   /evidence="ECO:0000259|PROSITE:PS50115"
FT   REGION          427..452
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          516..544
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          461..516
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        434..448
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   763 AA;  85219 MW;  8D9A1F5A5466422D CRC64;
     MIADMSSQYV TSSVAGRPFQ CADCSAADPQ WASLNRGVLI CSECCYIHRN LGRHISHVRS
     IKKGAWNSSQ LELMYVLYSN GSNNIWEHSL LDPQSTNKIR RKPTPHDPVL PIKENFIKAK
     YAQMAFALRP AKDDNCISQD DLNRQLWSCV RTSHVETTMR LLALGADPNY TDPEKHNTPL
     HVSAKENQAL QVELLWIYGA DPAQLNAIDL TPSQVAKLEN HIELAARLEQ LQFEVTNRLT
     MFLCGRRPDH SKQQYFLIPE LAGQYTENMQ MKSARRRLRS LPSYYFERFV QDVYDEVDRR
     ETVAAWNAVT QGIQPFSLGN DHCVAVFLPP NPELSATRNQ LRQKLAKCDV RGFATLIIDI
     LSEAKRRYYG LPLKNDTDDS AENLLKKTSD SMDRLNISSM GTSEYFTSFS EQDYRDYDEV
     ADSLQNGKWR TSGSTRKSSE RKSDDSGDLL QETGPVMIDD FLELKEKLAN TEGTLAAVQQ
     ANTQILRMLT HLQSNIDRLN ADNADVHDQL KKVKTTCSQA VGRRRSSQSP ALSPGTSVST
     SVLGSKNIAP TYHASTEKSV TASQNPDMHG AFGRASRRHG SGLTSSMNTT GKTIAQHRSF
     SLRQGTVQQT EYSSGVEGLD PHFGISCCEK TDLLNAVDER TEEERMRSSY RSIGAFTDNL
     IAETEQLTHA IKLLLTDAQY GQLQARAPDH AYSVAILISR ILTIIPEEQR TPAVETCLQR
     MSDSTVILSA KCNAPTFSVN DTCAAAFAVA NSAKQLLVNV HQF
//