ID   A0A0N4SYR8_BRUPA        Unreviewed;       422 AA.
AC   A0A0N4SYR8;
DT   09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT   09-DEC-2015, sequence version 1.
DT   08-NOV-2023, entry version 32.
DE   SubName: Full=MHD domain-containing protein {ECO:0000313|WBParaSite:BPAG_0000088801-mRNA-1};
GN   ORFNames=BPAG_LOCUS889 {ECO:0000313|EMBL:VDN82075.1};
OS   Brugia pahangi (Filarial nematode worm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Brugia.
OX   NCBI_TaxID=6280 {ECO:0000313|Proteomes:UP000038020, ECO:0000313|WBParaSite:BPAG_0000088801-mRNA-1};
RN   [1] {ECO:0000313|WBParaSite:BPAG_0000088801-mRNA-1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (FEB-2017) to UniProtKB.
RN   [2] {ECO:0000313|EMBL:VDN82075.1, ECO:0000313|Proteomes:UP000278627}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Pathogen Informatics;
RL   Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the adaptor complexes medium subunit family.
CC       {ECO:0000256|PIRNR:PIRNR005992}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; UZAD01000051; VDN82075.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0N4SYR8; -.
DR   STRING; 6280.A0A0N4SYR8; -.
DR   WBParaSite; BPAG_0000088801-mRNA-1; BPAG_0000088801-mRNA-1; BPAG_0000088801.
DR   Proteomes; UP000038020; Unplaced.
DR   Proteomes; UP000278627; Unassembled WGS sequence.
DR   GO; GO:0030131; C:clathrin adaptor complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0006886; P:intracellular protein transport; IEA:UniProtKB-UniRule.
DR   GO; GO:0016192; P:vesicle-mediated transport; IEA:InterPro.
DR   CDD; cd09258; AP-1_Mu1A_Cterm; 1.
DR   CDD; cd14835; AP1_Mu_N; 1.
DR   Gene3D; 3.30.450.60; -; 1.
DR   Gene3D; 2.60.40.1170; Mu homology domain, subdomain B; 2.
DR   InterPro; IPR036168; AP2_Mu_C_sf.
DR   InterPro; IPR022775; AP_mu_sigma_su.
DR   InterPro; IPR001392; Clathrin_mu.
DR   InterPro; IPR018240; Clathrin_mu_CS.
DR   InterPro; IPR011012; Longin-like_dom_sf.
DR   InterPro; IPR028565; MHD.
DR   PANTHER; PTHR10529; AP COMPLEX SUBUNIT MU; 1.
DR   PANTHER; PTHR10529:SF364; MHD DOMAIN-CONTAINING PROTEIN; 1.
DR   Pfam; PF00928; Adap_comp_sub; 1.
DR   Pfam; PF01217; Clat_adaptor_s; 1.
DR   PIRSF; PIRSF005992; Clathrin_mu; 2.
DR   PRINTS; PR00314; CLATHRINADPT.
DR   SUPFAM; SSF49447; Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor; 1.
DR   SUPFAM; SSF64356; SNARE-like; 1.
DR   PROSITE; PS00990; CLAT_ADAPTOR_M_1; 1.
DR   PROSITE; PS51072; MHD; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Protein transport {ECO:0000256|ARBA:ARBA00022927,
KW   ECO:0000256|PIRNR:PIRNR005992};
KW   Reference proteome {ECO:0000313|Proteomes:UP000278627};
KW   Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|PIRNR:PIRNR005992}.
FT   DOMAIN          167..420
FT                   /note="MHD"
FT                   /evidence="ECO:0000259|PROSITE:PS51072"
SQ   SEQUENCE   422 AA;  48892 MW;  69109B8180D335E2 CRC64;
     MSCSAIFILD LKGNVIMSRN YRGDVEMSVI DSFMPLLMEK EDEGLLAPVL QKHNISYVYV
     KHLNIFLVSI SKKNVNVAMM LAFLYKCIEV FSEYFKDFEE ESVRDNFVVF YELLDEMMDF
     GYPQTTESRI LQEYITQERY MLDIAPRPPM AVTNAVSWRS DGLKYRKNEV FLDVIESVNM
     LVNASGSVLR SEIVGTIKMR VLLSGMPELR LGLNDKVLFQ TYSRGRGKAV ELEDVKFHQC
     VRLSRFENDR TISFVPPDGE FELMNYRLTT TVKPLIWVES CMEKHAHSRV EYMVKAKSQF
     KRQSIANHVE IIIPVPSDAD SPKFKTSVGS VKYVPELSAF VWMIRSFPGG REYLMRAHFC
     LPSIIGEETE RKPPISVKFE IPYFTTSGLQ VRYLKIIEKS GYQALPWVRY VTQNGDYQLR
     MQ
//