ID   A0A0N4T156_BRUPA        Unreviewed;       611 AA.
AC   A0A0N4T156;
DT   09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT   09-DEC-2015, sequence version 1.
DT   27-MAR-2024, entry version 27.
DE   SubName: Full=Ion channel {ECO:0000313|WBParaSite:BPAG_0000188001-mRNA-1};
GN   ORFNames=BPAG_LOCUS1861 {ECO:0000313|EMBL:VDN83047.1};
OS   Brugia pahangi (Filarial nematode worm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Brugia.
OX   NCBI_TaxID=6280 {ECO:0000313|Proteomes:UP000038020, ECO:0000313|WBParaSite:BPAG_0000188001-mRNA-1};
RN   [1] {ECO:0000313|WBParaSite:BPAG_0000188001-mRNA-1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (FEB-2017) to UniProtKB.
RN   [2] {ECO:0000313|EMBL:VDN83047.1, ECO:0000313|Proteomes:UP000278627}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Pathogen Informatics;
RL   Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the two pore domain potassium channel (TC
CC       1.A.1.8) family. {ECO:0000256|ARBA:ARBA00006666,
CC       ECO:0000256|RuleBase:RU003857}.
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DR   EMBL; UZAD01000189; VDN83047.1; -; Genomic_DNA.
DR   STRING; 6280.A0A0N4T156; -.
DR   WBParaSite; BPAG_0000188001-mRNA-1; BPAG_0000188001-mRNA-1; BPAG_0000188001.
DR   Proteomes; UP000038020; Unplaced.
DR   Proteomes; UP000278627; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005267; F:potassium channel activity; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.287.70; -; 1.
DR   InterPro; IPR003280; 2pore_dom_K_chnl.
DR   InterPro; IPR003092; 2pore_dom_K_chnl_TASK.
DR   InterPro; IPR013099; K_chnl_dom.
DR   PANTHER; PTHR11003; POTASSIUM CHANNEL, SUBFAMILY K; 1.
DR   PANTHER; PTHR11003:SF240; TWIK FAMILY OF POTASSIUM CHANNELS; 1.
DR   Pfam; PF07885; Ion_trans_2; 2.
DR   PRINTS; PR01333; 2POREKCHANEL.
DR   PRINTS; PR01095; TASKCHANNEL.
DR   SUPFAM; SSF81324; Voltage-gated potassium channels; 2.
PE   3: Inferred from homology;
KW   Ion channel {ECO:0000256|RuleBase:RU003857};
KW   Ion transport {ECO:0000256|RuleBase:RU003857};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Potassium {ECO:0000256|ARBA:ARBA00022958};
KW   Potassium channel {ECO:0000256|ARBA:ARBA00022826};
KW   Potassium transport {ECO:0000256|ARBA:ARBA00022538};
KW   Reference proteome {ECO:0000313|Proteomes:UP000278627};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU003857};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU003857}.
FT   TRANSMEM        54..74
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        259..280
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        287..306
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        312..334
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          148..212
FT                   /note="Potassium channel"
FT                   /evidence="ECO:0000259|Pfam:PF07885"
FT   DOMAIN          265..338
FT                   /note="Potassium channel"
FT                   /evidence="ECO:0000259|Pfam:PF07885"
SQ   SEQUENCE   611 AA;  70739 MW;  46DF6C2FBB2E5A01 CRC64;
     MDLLTKLLHF TLLANTAANV IRQEAEVNIR RVRHVPRWMQ LLRKVYHEYG LKHILLIIVL
     IIYQFIGAAI FYLCEASHDE SLQTFWKENI KRNRTRLIDV IVSSMLNNTE YLFFLTSNQT
     RQIKRRLGQE LTLYEKGLGI KYTDQKIRWD FWNAMLYAQF NDMSCFQTIC TTIGYGHLYP
     STTAGRIFTM LYAIIDIPLV LSILDDLGKL LTRCLKTPWY LTKCGCRRLS RYCTKQTMTE
     IWELDAEDKR DLEIFDLPIP IAISVVITWI FICSATFCLW EKDWDYFVAF YFFFISLSTT
     GLGDITPTQP KYLLMLFIYI IIGLSLVSMC INLIQSEMAR TYEAGQLDNL SLNSADFSSE
     SINQRICNKN CISSSNGSNI IDGSARSLSD NSLWRISVNN RKKFNKSSQT MLSFLSPCGN
     SNMYKYDYNI GIKFLPRNLS IDDVMKLMDT EEEDILVLTG LIRADSNVSD NSDDSSQLCE
     ASKMKFIHSR LFYYYPRISS LLPNSPSTSL IQQNTFPNLN GASMTLSMHD IETNDEMEDQ
     ILFERAATML NSSAAYFRSR PNLVPQRHNI TEDDKKEEEK DDEEICTVHT KFTEGPQICR
     IDLGFRYIYA I
//