ID A0A0N4T446_BRUPA Unreviewed; 2846 AA.
AC A0A0N4T446;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 09-DEC-2015, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE SubName: Full=AMP-binding enzyme family protein {ECO:0000313|WBParaSite:BPAG_0000297601-mRNA-1};
GN ORFNames=BPAG_LOCUS2946 {ECO:0000313|EMBL:VDN84132.1};
OS Brugia pahangi (Filarial nematode worm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Brugia.
OX NCBI_TaxID=6280 {ECO:0000313|Proteomes:UP000038020, ECO:0000313|WBParaSite:BPAG_0000297601-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:BPAG_0000297601-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (FEB-2017) to UniProtKB.
RN [2] {ECO:0000313|EMBL:VDN84132.1, ECO:0000313|Proteomes:UP000278627}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Pathogen Informatics;
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the ATP-dependent AMP-binding enzyme family.
CC {ECO:0000256|ARBA:ARBA00006432}.
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DR EMBL; UZAD01000610; VDN84132.1; -; Genomic_DNA.
DR STRING; 6280.A0A0N4T446; -.
DR WBParaSite; BPAG_0000297601-mRNA-1; BPAG_0000297601-mRNA-1; BPAG_0000297601.
DR Proteomes; UP000038020; Unplaced.
DR Proteomes; UP000278627; Unassembled WGS sequence.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR Gene3D; 3.30.300.30; -; 2.
DR Gene3D; 1.10.1200.10; ACP-like; 3.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 4.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 2.
DR Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 3.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR001242; Condensatn.
DR InterPro; IPR009081; PP-bd_ACP.
DR PANTHER; PTHR45527:SF1; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR45527; NONRIBOSOMAL PEPTIDE SYNTHETASE; 1.
DR Pfam; PF00501; AMP-binding; 2.
DR Pfam; PF13193; AMP-binding_C; 1.
DR Pfam; PF00668; Condensation; 4.
DR Pfam; PF00550; PP-binding; 3.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 2.
DR SUPFAM; SSF47336; ACP-like; 3.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 7.
DR PROSITE; PS00455; AMP_BINDING; 1.
DR PROSITE; PS50075; CARRIER; 3.
PE 3: Inferred from homology;
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000278627}.
FT DOMAIN 902..977
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 1522..1597
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 2623..2698
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
SQ SEQUENCE 2846 AA; 326749 MW; 358E36ABBCD4102B CRC64;
MRIFVTEQED NKDNKKIKES ISNEICQEKD QRMLGKKQTM NTDIKNSNLI VIQIHHIMID
GSSIKLLTDE LRIFYYEEKS LRSIPYQYGH FVLMEDQQRQ NRKLYKAFWK HLLFDVTLQK
LPVDETGLQA GKYSGRCLQF KIDSKIQKSL QNLAIWCSVT QFSVLLTNFQ LLQYKRYGFK
DCCIGIITAQ RETSELCTII GCLLNVVPLI NTINPNDRIH DFITKSYKHL NESIQKQLQF
DDLIAALRLE RDLPNSPLFQ VLFISDDSGD ISYNDDANES NFAQYDQVWH FQYYNESMTL
KIEYNSSRFY KNTIETMVQQ YFRLLHKMSQ NLHMLIKSIK MVSSMEEFMD YKLRIENRCD
FPQKCTVLNI IDEQNKMNFY GNTIIQRGVP FSNVFLQQKS NQLSRFLTQR WLQFLGEDMR
NDSFVLLILD RSVFLLLSIF SLWKCGIGVA PLNLETSLEQ LNEILAKLSY PAIIYECKEN
NVANQCISKN FYGTMLQNSE KQNSVFGHDI NEIITVISGY SDQELRKKLT QHNLAYMTFT
SGSTGTPKGI CTEFYGLNNL VLNYAEFLSI KSSSIIYQVV NPSFDIFFAD ILEAQTSGAS
LYLASQRIPD LEEMSKVTHA YIMPAYLSVV EPEQFKKLEN LEKINFGGDY IQYKVLQDAI
RIGLHFHNQY GMTEHSIYST CKLMKVCDKT SSVGKPLKNI FFSIYDGDKN LCGQHITGIC
CSSGAGISRG YHDNENLNQI SFLNNNDLTR LELLLNHDKR YFYSGDLAQI KSNVGQLLFH
GRSDFQVKIR GMQVDIPTIE AVLGQNHLVK ECIVCLRRIE GEEFLIAYII SCNDIITEEE
KGQLMIKSLN EYMLGKLSAF MIPSHYVFVQ QFPLNINGKI NRKLLPLPEK LLNSKIPLKT
DCIFEPWEKQ VMGIFAALLP GKAIQIDDSF FEAGGDSLKA LIAIQNIKRE TGMDLQLRDI
FKLASFRAIL ERLKVTHSIG NHKEVENLTM LESAKFRPNV LQINGRSGKL TDDQLVNNVK
ISDNVDNNRS LNKKMSSKYN GDKKSRFWLN GSIPVSLQQE RLLFLYSFGK EYRESYKLQF
LIIFYGFVDL KVLNTALNYI MRKHRLLRTI FLQKVAKVIQ EVTSLSECYI EVCKNVLGYD
ITGSEISSEL PSIYDTPLLA VTVSDNLELM LILDHLIVDG RSIAILTNDL VEFYNILING
GSVSFDFTEG TSYAEFCLQQ RRELEKFRVA LKGADCLTLI DRAVAKDEVE VQEKWLLKLR
DFPPLSLEGD LSNEEFDRRN NVIRLKIPLY LSAIKHFCVA ERCTLFAYLL GVFSLTVRSL
CDQQKHRFAV VTSALNRTSD TINCVGLFVN TVIIPIDTAF DCVSELIHSL QQNITEALQF
QHIPFDYIIR KLNGTRSSSG TESYQVSFVV QNASATKLPR IDGVETIVEE INAKYAKFDQ
AWYCTEFEDY IEVSVEYKIE KYSDLEIKYA MELFVQIASQ LLSNRSMKVK GILKSCELIR
VEKPLIENNN SKNVNATEGT IKKSLMLEEV LLGIWKEVLE CSEISVFDNF FAIGGHSLLI
PNICYKIEQQ VNYQCPPQAI FKYQTVRELA QHINNKQDLK ILTTSNEKLK IRVCPLQESL
AKMYYNAATE TSISSLPTTT TTATTITSDL IKAYQTGFSI ALKCINFSKL RHSLNLILMR
HFALRATFYC QNNDFFQQIH SGTEIYITPR KTNIEGASLI VPNPFHAIPI LCWLIDGIKQ
ELPDDSYCEF HFKISHIICD GKSLSIIARE LSNNYFEDRH ISVKDDSFIQ FSKRLKQRFQ
ERYTEMQKFW SQNLNNTEGA NIHYEKITAT VSSNNRCKFF YKKFKSLNIL IKRVAKKCCC
SPFVVQLAAF SKVLSGIATQ DSKMIISCPI DMRDSRAQQC VGMCINVLPV IINFRLRNYQ
DLIQDIAKSF ANAYINADIS NDEIEKLCEK YGVSNFADIM IVNNYKQYSS HCYQILNDNS
EFTKCTLTLF LTQYHEDIEA KIECKQDFFY DESMKIMLNQ WAKTIRKMEK VIVTNDEIES
KEKRRYPHEI FFSKEHFSVK NMDIRSKERL ASSGCDNDEN VLQKSDYPAF SYQHLLREAF
VANRQWTAMT VLTESKESIN YRTLTGLIYR TAKIIREKVA QITGGILRSD TVIPVIAHNS
IKTLATCLAI TMTGAAYLPI DSTGPAKRIS NILEQIGAKF YVTVDQLINN DDEFQISFNF
SFQNALEINL NNMRFDKEPL ELPPHLQNTP NDLAYTIFTS GTTGKPKGVT IGQHGLLNMA
IACTRDFWMK PGDCVYQFTN FAFDNSVLEI TMALINGSAL LLREDYFTPH TFLNEVKHGN
ITHALLFPSL VNTFKDEEIG ELRHLRYWIV GAESASKRIL ECALKSGVNV IQNYGPTETT
AYALTKRMKL LDRPNNIGRG ITNVVVTVRN FCGEIVQEMG VGELCIKGVG ITRGYVISSD
RIRENAEKEI ESKKFGEVDS CCSISPGNNF GTKDMVRMQP NNEILFLGRY DKQVKIRGYR
VELGEIEAIL CQYPQVKSAK VILKLIGQQR QLAAFVILSD LFENRFHPAA IRHFMQQHLP
YYMIPIQYHF LQQYPLTKNS KVDVEALAML QNPENDQCLR HAEPENSMES TLLGFFRKVL
QNDNISVNDD FFAVGGNSFS ATRLTELIEA NVAHCIGISN VFRHRTVRRL SQHILHFHKK
PSNEIYGIQK FSGINKSDFN LGNIPLSFQQ QQFQFLNETK ERQYYELIFV QKFDASLSLQ
HLKLAFLRLI LRQPSFRTIF PERNFDVHQE ILSGTEVYFY SSAVQSSSFP KGLVSYDENT
TAEKIKILQD VEVNLKSEPP VLCAIE
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