ID A0A0N4T7H6_BRUPA Unreviewed; 373 AA.
AC A0A0N4T7H6;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 09-DEC-2015, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=MMS19 nucleotide excision repair protein {ECO:0000256|RuleBase:RU367072};
GN ORFNames=BPAG_LOCUS4127 {ECO:0000313|EMBL:VDN85313.1};
OS Brugia pahangi (Filarial nematode worm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Brugia.
OX NCBI_TaxID=6280 {ECO:0000313|Proteomes:UP000038020, ECO:0000313|WBParaSite:BPAG_0000416301-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:BPAG_0000416301-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (FEB-2017) to UniProtKB.
RN [2] {ECO:0000313|EMBL:VDN85313.1, ECO:0000313|Proteomes:UP000278627}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Pathogen Informatics;
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Key component of the cytosolic iron-sulfur protein assembly
CC (CIA) complex, a multiprotein complex that mediates the incorporation
CC of iron-sulfur cluster into apoproteins specifically involved in DNA
CC metabolism and genomic integrity. In the CIA complex, MMS19 acts as an
CC adapter between early-acting CIA components and a subset of cellular
CC target iron-sulfur proteins. {ECO:0000256|RuleBase:RU367072}.
CC -!- SUBUNIT: Component of the CIA complex. {ECO:0000256|RuleBase:RU367072}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, spindle
CC {ECO:0000256|RuleBase:RU367072}. Nucleus
CC {ECO:0000256|RuleBase:RU367072}.
CC -!- SIMILARITY: Belongs to the MET18/MMS19 family.
CC {ECO:0000256|RuleBase:RU367072}.
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DR EMBL; UZAD01001760; VDN85313.1; -; Genomic_DNA.
DR STRING; 6280.A0A0N4T7H6; -.
DR WBParaSite; BPAG_0000416301-mRNA-1; BPAG_0000416301-mRNA-1; BPAG_0000416301.
DR Proteomes; UP000038020; Unplaced.
DR Proteomes; UP000278627; Unassembled WGS sequence.
DR GO; GO:0097361; C:CIA complex; IEA:UniProtKB-UniRule.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-UniRule.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005819; C:spindle; IEA:UniProtKB-SubCell.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-UniRule.
DR GO; GO:0016226; P:iron-sulfur cluster assembly; IEA:UniProtKB-UniRule.
DR GO; GO:0097428; P:protein maturation by iron-sulfur cluster transfer; IEA:UniProtKB-UniRule.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR039920; MET18/MMS19.
DR InterPro; IPR029240; MMS19_N.
DR PANTHER; PTHR12891; DNA REPAIR/TRANSCRIPTION PROTEIN MET18/MMS19; 1.
DR PANTHER; PTHR12891:SF0; MMS19 NUCLEOTIDE EXCISION REPAIR PROTEIN HOMOLOG; 1.
DR Pfam; PF14500; MMS19_N; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|RuleBase:RU367072};
KW Cytoskeleton {ECO:0000256|RuleBase:RU367072};
KW DNA damage {ECO:0000256|RuleBase:RU367072};
KW DNA repair {ECO:0000256|RuleBase:RU367072};
KW Nucleus {ECO:0000256|RuleBase:RU367072};
KW Reference proteome {ECO:0000313|Proteomes:UP000278627}.
FT DOMAIN 37..308
FT /note="MMS19 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF14500"
SQ SEQUENCE 373 AA; 43650 MW; D19EDB4F705D74D5 CRC64;
MNGDKETIAE VDDDLCFVNQ WVDKLSHGKS FTLRVFVESF QSEMKSNNRE KRENGLKRIC
LVISKLPQNY PWELPHVELL MNFFLMNYSI FDTPNFFILT VLKKLLMNNL HVKSSSIDSL
VDTLFRQGQV QTCAQRERFV FYQILDLLLN KYSKELSTNT YFISYFMSSV SGERDPRCLI
LVFRLFCTFF KHFNSGDFQR NLLDLYASDL FDIIACYYPI EFNHNSRERT EITRELLVSG
CESCLLADEE FAPFVFELII EKLLDSEYST DTKLEICSFL AKACAFFPCY QLIDHIGQLC
AGIRSVLFNF PNDTRDDYIP ESITAAVSSI IKAFDRSNIK DKRQHIESIC HEFIESKTFK
FSLNVFFFKK IND
//
