ID A0A0N4TK29_BRUPA Unreviewed; 921 AA.
AC A0A0N4TK29;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 09-DEC-2015, sequence version 1.
DT 24-JAN-2024, entry version 36.
DE SubName: Full=ANK_REP_REGION domain-containing protein {ECO:0000313|WBParaSite:BPAG_0000867701-mRNA-1};
GN ORFNames=BPAG_LOCUS8639 {ECO:0000313|EMBL:VDN89825.1};
OS Brugia pahangi (Filarial nematode worm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Brugia.
OX NCBI_TaxID=6280 {ECO:0000313|Proteomes:UP000038020, ECO:0000313|WBParaSite:BPAG_0000867701-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:BPAG_0000867701-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (FEB-2017) to UniProtKB.
RN [2] {ECO:0000313|EMBL:VDN89825.1, ECO:0000313|Proteomes:UP000278627}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Pathogen Informatics;
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; UZAD01013138; VDN89825.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0N4TK29; -.
DR STRING; 6280.A0A0N4TK29; -.
DR WBParaSite; BPAG_0000867701-mRNA-1; BPAG_0000867701-mRNA-1; BPAG_0000867701.
DR Proteomes; UP000038020; Unplaced.
DR Proteomes; UP000278627; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005216; F:monoatomic ion channel activity; IEA:InterPro.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR024862; TRPV.
DR NCBIfam; TIGR00870; trp; 1.
DR PANTHER; PTHR10582:SF2; INACTIVE; 1.
DR PANTHER; PTHR10582; TRANSIENT RECEPTOR POTENTIAL ION CHANNEL PROTEIN; 1.
DR Pfam; PF00023; Ank; 1.
DR Pfam; PF12796; Ank_2; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR SMART; SM00248; ANK; 5.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 2.
DR PROSITE; PS50088; ANK_REPEAT; 2.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000278627};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 412..432
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 452..471
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 492..513
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 519..539
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 560..581
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 643..664
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REPEAT 192..224
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 248..280
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 418..674
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT REGION 791..810
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 921 AA; 105616 MW; F960953540E5649A CRC64;
MGQLKSKILH QTGGEDIDNL KEDPDDQWSN LYRERKKNHL YKWVGMRSGG ELLAAFEKEG
EDGVLKFANE KLISMMYDDG ASPQMIRFTD YAKWKKTTAR FFFFFCNWTV LLCKRLLNVQ
LGKTESNSVG QFGSKFREHL GQWRLNKRGV EGETIIHLLL NREEPMCSEI ARILITRYPG
LANDIYLGDE MFGQSALHLA IVHDDYETVH LLLQNSAEVN ARACGTFFLP ENQKTSRKST
DYQGYAYYGE YPLAFAACFG NKDIYDLLIQ YGADPNLQDM FGNTILHMCV INYSNSMYSY
AVRHWAKPAD PNIVNAAGLT PLTLATKLGR KDIFEEMLEL MKVEFWRFSD MTCSAYPLTA
LDTIRPDGST NYDSALMTVI NGSTSEHLDM IGSEVIQRLL ADKWKAFASR KLFERLGLLI
LHLIFLCFVV YMRPSEPERL MYKLIATEWN DWVRLCFEIL TIASCVFFVF FQQFSELRTQ
GFYGYIRNLK TAPAKIVFLG ANICILICVP FRISGNVQVE EALLVFSLPG SWIFFLFFAR
SAKLTGPFVQ MIYSMIAGDM IRFAIISAIF LVSFSQVFYF LGKDMHVKQE LNPLNPDYCE
VKGYDIFTYS SFLETFITLF RASMGGYDYE EFSCANYEVL TKILFVLYMF IMPIMLINIL
IAMMGNTYTT VIAQAEKAWR QQYAQIVMVL ERSVKKEKLA ACQLEYSIRL NEANDAGMEI
RGLMVIKQTK KTRARQRKQA ITNWKTIGRK VIHTVERLGV GYAQELLHSY NCLIDEPAGA
VILRRDTVFP PPTRSMTRSR AHETSTNTQN EEKIEHLNNI SIEKEIIVNN CSNQTSLQCQ
SPRDFSDTTM ILEKLPMRKT ARGHQLVPSL DIPNMPAAGT PPRAISPRIR KDMFRRKDSF
CASSSSASSS TQVRKFIFKF M
//
