ID A0A0N4TKM2_BRUPA Unreviewed; 461 AA.
AC A0A0N4TKM2;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 2.
DT 27-MAR-2024, entry version 33.
DE SubName: Full=Phorbol-ester/DAG-type domain-containing protein {ECO:0000313|WBParaSite:BPAG_0000889701-mRNA-1};
GN ORFNames=BPAG_LOCUS8859 {ECO:0000313|EMBL:VDN90045.1};
OS Brugia pahangi (Filarial nematode worm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Brugia.
OX NCBI_TaxID=6280 {ECO:0000313|Proteomes:UP000038020, ECO:0000313|WBParaSite:BPAG_0000889701-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:BPAG_0000889701-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (APR-2016) to UniProtKB.
RN [2] {ECO:0000313|EMBL:VDN90045.1, ECO:0000313|Proteomes:UP000278627}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Pathogen Informatics;
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}.
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DR EMBL; UZAD01013142; VDN90045.1; -; Genomic_DNA.
DR STRING; 6280.A0A0N4TKM2; -.
DR WBParaSite; BPAG_0000889701-mRNA-1; BPAG_0000889701-mRNA-1; BPAG_0000889701.
DR Proteomes; UP000038020; Unplaced.
DR Proteomes; UP000278627; Unassembled WGS sequence.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd21885; SARAH_RASSF1-like; 1.
DR Gene3D; 1.20.5.110; -; 1.
DR Gene3D; 3.30.60.20; -; 1.
DR InterPro; IPR046349; C1-like_sf.
DR InterPro; IPR002219; PE/DAG-bd.
DR InterPro; IPR000159; RA_dom.
DR InterPro; IPR033614; RASSF1-6.
DR InterPro; IPR011524; SARAH_dom.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR22738:SF10; RAS ASSOCIATION DOMAIN-CONTAINING PROTEIN 1 HOMOLOG; 1.
DR PANTHER; PTHR22738; RASSF; 1.
DR Pfam; PF00130; C1_1; 1.
DR Pfam; PF16517; Nore1-SARAH; 1.
DR Pfam; PF00788; RA; 1.
DR SMART; SM00109; C1; 1.
DR SMART; SM00314; RA; 1.
DR SUPFAM; SSF57889; Cysteine-rich domain; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS50200; RA; 1.
DR PROSITE; PS50951; SARAH; 1.
DR PROSITE; PS00479; ZF_DAG_PE_1; 1.
DR PROSITE; PS50081; ZF_DAG_PE_2; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00023212};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Reference proteome {ECO:0000313|Proteomes:UP000278627};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 145..195
FT /note="Phorbol-ester/DAG-type"
FT /evidence="ECO:0000259|PROSITE:PS50081"
FT DOMAIN 282..390
FT /note="Ras-associating"
FT /evidence="ECO:0000259|PROSITE:PS50200"
FT DOMAIN 392..439
FT /note="SARAH"
FT /evidence="ECO:0000259|PROSITE:PS50951"
FT REGION 1..24
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 461 AA; 52809 MW; 9CD542F5330734A8 CRC64;
MSKTLDYGGN SNNESDGKNV RSCQSATQQP RWFSGLRARI SQLNMPEWLS QLGVKNFNYV
APTEEVLPGN KAEKKTDYKN DQPVRILDDV SKKLQICIHP EIDVNGSDTI GSWLWEEADY
DDTLALQHFG PLKNLITGCS HPGKGHDFLS LSVTHPTWCD KCGDFMWGFL TRAVKCGNCN
YTCHSKCKSL VTLDCKTADS TLSSCQELAV TSCSNLKMFS ENDNILEEQK DETSGFVQIH
MNFMRPINVV AGDSLSFLDV TNESGEFFSM TLFCNAVLRS VTTSSLRTIT TFFLPRNTVK
NVNISSKMTT RHPIIFFFRE MIITLLRKFR VADNPRKFAL YERVSQSLEN PTIQNYSLTR
ISDDSFPLKI VRSWEEKGEK RQLVLQENDT GDILWDMFEV PELENFLKIL EDEEKQYCFR
IRQKYDAYRW YLDENLRNRG FTVDGDEFSS VKANSCISTD V
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