ID   A0A0N4TKZ1_BRUPA        Unreviewed;       593 AA.
AC   A0A0N4TKZ1;
DT   09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT   09-DEC-2015, sequence version 1.
DT   27-MAR-2024, entry version 33.
DE   SubName: Full=Peptidase S72 domain-containing protein {ECO:0000313|WBParaSite:BPAG_0000903201-mRNA-1};
GN   ORFNames=BPAG_LOCUS8994 {ECO:0000313|EMBL:VDN90180.1};
OS   Brugia pahangi (Filarial nematode worm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Brugia.
OX   NCBI_TaxID=6280 {ECO:0000313|Proteomes:UP000038020, ECO:0000313|WBParaSite:BPAG_0000903201-mRNA-1};
RN   [1] {ECO:0000313|WBParaSite:BPAG_0000903201-mRNA-1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (FEB-2017) to UniProtKB.
RN   [2] {ECO:0000313|EMBL:VDN90180.1, ECO:0000313|Proteomes:UP000278627}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Pathogen Informatics;
RL   Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; UZAD01013144; VDN90180.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0N4TKZ1; -.
DR   STRING; 6280.A0A0N4TKZ1; -.
DR   WBParaSite; BPAG_0000903201-mRNA-1; BPAG_0000903201-mRNA-1; BPAG_0000903201.
DR   Proteomes; UP000038020; Unplaced.
DR   Proteomes; UP000278627; Unassembled WGS sequence.
DR   GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-KW.
DR   GO; GO:0016010; C:dystrophin-associated glycoprotein complex; IEA:InterPro.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   Gene3D; 3.30.70.1040; Dystroglycan, domain 2; 1.
DR   InterPro; IPR027468; Alpha-dystroglycan_domain_2.
DR   InterPro; IPR015919; Cadherin-like_sf.
DR   InterPro; IPR008465; DAG1_C.
DR   InterPro; IPR030398; SEA_DG_dom.
DR   PANTHER; PTHR21559:SF21; DYSTROGLYCAN 1; 1.
DR   PANTHER; PTHR21559; DYSTROGLYCAN-RELATED; 1.
DR   Pfam; PF05454; DAG1; 1.
DR   SUPFAM; SSF49313; Cadherin-like; 1.
DR   PROSITE; PS51699; SEA_DG; 1.
PE   4: Predicted;
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00023212};
KW   Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Reference proteome {ECO:0000313|Proteomes:UP000278627};
KW   Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           20..593
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5033720654"
FT   TRANSMEM        482..506
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          335..450
FT                   /note="Peptidase S72"
FT                   /evidence="ECO:0000259|PROSITE:PS51699"
FT   REGION          556..593
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   593 AA;  67395 MW;  3E4137438DB6A0C3 CRC64;
     MECFKSMLIL FICIISTVAQ IPEIVELVVG QPFYYAFQID SNVLDVQDAS GEELPTWLIW
     KRNERWILEG VPQPTDAGKT FLRITNGQTN YVMEISVKEE IVNPCGVERN ILWMEIAFDT
     SLSSLSIADQ LDLVNIVSKF FNINSSSLRI YSNKYKEEVG RSEVVESGMQ NKPKNDSVTI
     MWKVSCEEID EDAIDVLEKM LTFDESDALA MSRQKLFGWE LRKGTLLPRK QRNHIAGTNI
     LSQLSGFITN EPYSEATTSK TTARLSRSTK KDDRPPVRLH SLQTFTCRRG MMCEYTIPRE
     TFIDVEDGDT RSLTLSVYPI MTSAPFRVTV VPEPPTNHLF ILDVDHSSER LAKDPDILCA
     FAEKLANSLG DRFPKNLVIK KIEAIDSVRR QSRVMFSNSS LSYKYCQKKA IEAIKHIMLT
     RRRDRIRAEF VRAMDSRFHV RNVKLELRGS CIEEMPISRL PTNVSLSSTT VLPNYDTSSV
     QLWLPVALIA FLKFFLATLA LICCLIKRKK AKAVQSEYIS KGLPVVFPEE IPQADETATV
     STPMLVKEER PPLIISQHEN PLYKPPPPLS TASSPRPRNA FTNQRQPPPY VPP
//