ID   A0A0N4TLN9_BRUPA        Unreviewed;      4539 AA.
AC   A0A0N4TLN9;
DT   09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT   08-JUN-2016, sequence version 2.
DT   22-FEB-2023, entry version 29.
DE   SubName: Full=UBR-type domain-containing protein {ECO:0000313|WBParaSite:BPAG_0000931501-mRNA-1};
GN   ORFNames=BPAG_LOCUS9277 {ECO:0000313|EMBL:VDN90463.1};
OS   Brugia pahangi (Filarial nematode worm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Brugia.
OX   NCBI_TaxID=6280 {ECO:0000313|Proteomes:UP000038020, ECO:0000313|WBParaSite:BPAG_0000931501-mRNA-1};
RN   [1] {ECO:0000313|WBParaSite:BPAG_0000931501-mRNA-1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (APR-2016) to UniProtKB.
RN   [2] {ECO:0000313|EMBL:VDN90463.1, ECO:0000313|Proteomes:UP000278627}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Pathogen Informatics;
RL   Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the UBR4 family.
CC       {ECO:0000256|ARBA:ARBA00009970}.
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DR   EMBL; UZAD01013151; VDN90463.1; -; Genomic_DNA.
DR   STRING; 6280.A0A0N4TLN9; -.
DR   WBParaSite; BPAG_0000931501-mRNA-1; BPAG_0000931501-mRNA-1; BPAG_0000931501.
DR   Proteomes; UP000038020; Unplaced.
DR   Proteomes; UP000278627; Unassembled WGS sequence.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   InterPro; IPR025704; E3_Ub_ligase_UBR4_C.
DR   InterPro; IPR045189; UBR4-like.
DR   InterPro; IPR003126; Znf_UBR.
DR   PANTHER; PTHR21725; E3 UBIQUITIN-PROTEIN LIGASE UBR4; 1.
DR   PANTHER; PTHR21725:SF1; E3 UBIQUITIN-PROTEIN LIGASE UBR4; 1.
DR   Pfam; PF13764; E3_UbLigase_R4; 1.
DR   Pfam; PF02207; zf-UBR; 1.
DR   SMART; SM00396; ZnF_UBR1; 1.
DR   PROSITE; PS51157; ZF_UBR; 1.
PE   3: Inferred from homology;
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Reference proteome {ECO:0000313|Proteomes:UP000278627};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833};
KW   Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT   DOMAIN          1284..1350
FT                   /note="UBR-type"
FT                   /evidence="ECO:0000259|PROSITE:PS51157"
FT   ZN_FING         1284..1350
FT                   /note="UBR-type"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00508"
FT   REGION          2396..2420
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        2404..2420
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   4539 AA;  511339 MW;  E8DE98F0636EBBC9 CRC64;
     MSWSLASNAN QKSGHINSLL KYVISNGSSM QPDETILSIH VIGTNLHKLP SNDLLLASEA
     YRVLINQFTK QLNEELVITI HLVDIIRCLL TGTALPTEYH SYLCSQQINQ KKHDTVEAAQ
     PCIQLNISTK EILAINGLSL FSSFSIEKLI SAFIPAKFLD PFRSAVAHPS FPAYSKIDHS
     DLSILENGIS NIDKLLCIDF GMATETVVEC ISCTSNALIL MIGSLACNCT IEEMHTDAAN
     ACCATVISVH RRVTEMAVGT LYARNHLTNS TEILVFCINE LLKNCKTEIV YVFANRFLSV
     LPTALSFLTF ISSALYEALW GVAKEALQHA LRLGDATSVK KQASTDSPDD PVAGVGDWLE
     NILRAVPVLM DQQEDAINLQ KATLFTISSS TLLSLCERSL SLLLFMGNTS NIWTSSSFNC
     FRDLCAASGG DHGYCGTEDI SALLILLLEH SLDKGYLEKN YNEQLVNSLL YFPKDNESEI
     ITSDPFCLKI IAVCVLGRQN VARIVSHVLR SIDAESRNGT PEPSTFWLLE CISELLDIED
     LKKSADYAMH MLYDVLKSGV KRPRVRYTLE AVHLLLVGGQ SRGEKDVVME KFRKCCCDFF
     DLKRAPRWND ALLTRSMFNF NHWDELHDLY INWLYDMQWD EEHLPAHIIL PPTVSFLSKI
     VSGTAILSAE RCHFIRIRPL LLNSIYAAYL DKFNDGITNI YVDYVLKVET LVTIGLPIID
     DCSLIDLVNL PLIYYDSLLL FYNQLRKYRC STEELIRITE FISGMYKNAI NVICERSKVT
     LSLGACAVSL SLAKSDVLNS TVPHARGELH SILNDDLLKL VRAWAGLMLP ELKFSCTPAM
     LDAISDTFKS PCSVVTKVQD IKKQVKITNT FKINGKDIRS HFQFALQMFA AFCSLCDNTT
     RFVLNQLLSR SCVRRQEETR LLLDWMIFIQ SSDLTGTATR ELNQSVLSKM NAVLVMSSHL
     ARIVSTLLDG ILAQQIATET NLLNGQSVFC SVLIHLISSQ SSVNLPWNTL PEDIFSSVLS
     HIAMDDSLTK RSVPFVNLLS TICCLKNSHL NSRFLSPLEI HQNLLVHWVN VSAVPLETFC
     MLQPLIEYLA GDRHRKPNFV DPAFRNLLGQ MINILFGENV HQRTADSSSI EVKRSDRWAY
     ASLCCRKMNN QNEKDNSSSD QRCEQFKEMN IFSKCLLTLL NIGGPKIHCH LIQQCAKLFC
     NLVDVIRKDG LELLKGSSNV SSSQVTTVLY AFFFLCNILD YIDSLCRTLC PPSVIRDDSD
     DLFTVFTPKH IIKKTTSSRS RALPLCTFAS TAKQFIQQHW YNCYTCGMVE GEGVCSVCAV
     NCHRGHDLSY SKFGSFFCDC GAKGCVALKS TSHPKPQRVS NQKYTTLPSN RLKSSKHRLS
     LFSHLLVMDE DKAEIENHLC QFMEVLTANR ENIVSLITAV KEGVRLRSNK IRETRLNDVG
     AKLTQGLTIS TDRVIMEPLT ACPKTLFDKR TETGKSVDNI IASLEIGGTI LLAAVQETSK
     IVLLGIRSLL SASMRDCDIP RVELDVAGFK IVALASMNDL LAVCGLNQCL ILRISKDGDV
     SEKQNVEFTN AFPSYVVPKL TIYVDNILAN LFCSPVTAAF FKMRWINCNN NNMIAVAALQ
     FIRIYDLNSA NVPSTFEFVL PMGDVTELAF GKRNDGLIII IVLSSAGHVY MEELEKARRA
     DGASYFMTTT LQLPTTSSAI SMHYSTEIRF LFVSMESNTY VLHFNGTEFE EAKSLPFDFP
     LMNWCECAGV FAALSHPSSA CVVFLYPYGN TLYTQTKTLT DPATTQCMLL GSDCVSQFLI
     QILADQNIQL FRSCWLMEPD FWVKDVERSV LETEVKPCTI MEDEIPESDM VTVFEQCRPI
     QKLEFCSKAL EQVYDTVELT KRITTSGMSA VCLKQKEFEV VVKNLDWNCV ICALRIEVTP
     DKCPTSVTVF GKKINLQTKT PRMFDVRLTR KQSINCNNEV TLNFICNNVP AQIWSIKVFG
     KTKKDFGFPT ASYRFNQIIT LPEQLVASFI STCYRLHSCT KQKRMDWLLS VALNFTAPDF
     EHVTVNHRAL ILLRHLSPTT SSFLEQKDAA LFSSLSNHRK AGTLQLSLFN AFATQLKVIT
     LHRVTSFHQL IKKHFGGILP FLNICVDFIF SNDFAADAIL EQFLISAFVY LAVNVENSAE
     ITQLILEILF SDNIVIAHRC KCLMSSIISN YCIASVQNHS NLFSFIGAIT PTTLTDKYTA
     SAEGLHMGVV IQDAIGFKPA IIDELENQIN KEKGIPVQLN PSSNLENFNR KMAWIGQLLL
     AFVSRLDICS CDGIRCLAPA QTILFLMGQH APDQLTDLID YLISGLDFSK VQTERTVKAE
     RDQVILRLIY VILVQCTSHN WPSMNSRKIV DDGIQSVTIP KSAELTTILD TAADVSAVPP
     AGSVEDEDDA EGGGESDLEQ MEDIELTGDI SSSSRDATPQ QDDTDMSAIN NVPQVASQEH
     EGVSVTPEPQ VSLAVKVAHT LESAGALNHC YILLQSLKTE WTKQMQSAEQ TIQKLSSVPP
     ELQPDLAPLF NARSLNVNPG NVFSIYTTLI VEMALRLPYQ LKKILGDELL LDNKWENLLC
     DYITQEPSTM RRLARKLLLL MCGSDTAKYR QVRDEHIIHD LLANLKKRLK SRSSLEYFEL
     SDIVSRINGI AVVSERRCVV WQRICLKELP WLMELACMMP DVACDAVLNL ILLAIRTSED
     SDDELLCCSL VNILLSKQKP CALFKRLITR FLLGENEERR WTLHAILRAT LQLASRPNQL
     LLINYLYKHT WPYAHEMGNR AAQLVDLLSC YLPRFLSKDE LITVYKEAVA TINSALYTLE
     KSRSSVIFEK LCEFIGSPDI SVLSKSPCLI CSDSDHPMEQ LKLSAIKLDS RFTTSAQMIK
     LMGHFEVSRI IIRLSEIKRT KMVKRFRFYY CNKILESAID LKNRPELWEK AADVKVNQGD
     TEIDVQLPIP VVTCNVVLEM AEFYDTNTAG AADAPEFVHC PRCSTSVTPN PGICSNCGEN
     VFQCVKCRAI NYDEKEPFLC NSCGFCKYAR LEAVLVGRSL PSVQAIEDDN DRKTTYALME
     TLLNDIESTR CHIGIIRAFL EKCSWDSEPN IRPNMILKHM TVQSFTSFMS SLNLKEDYTL
     ATLYRSAEKL HNKLCEQTRQ LAAFRAEILR YDIENGDETL SDKPRTSNFH SNSDRCVGCM
     SALIVHCVSL IQATCSDTNA MEEIIREDFV FSRLVSFVMI GKTNSEPTSS NMVKVKYRKL
     MASCLDKHNL KYHAVAFWYQ EVNGCTLGDA VARSVHSLIW NLSEMSKEAT QKMCELVENG
     ALPCYLLTKS IFENKFRFWE QKLRCLMRMA VIGNGSTEMD LHVLAVFLKI CSPCSTNLKN
     TFAVDSSGFS VDKVRNAGTF AVYLLPGYLL PTREEQSKTV LNASQNIGLE DNHKESEQEE
     VEQNLVLDDT VLHKIMEDMK MLDEEEPDFD KLLIPSERFP TIGWLKGRFI WAEYTRLLQN
     DGPERERSIL QYIRRCTESD PKRKFSLYQW LTRCMFSSVA AVRAATCRLL VMLCFEINNN
     GEAQIGSPVD IALVLQKVLL WMRKIRNVSA DNIDEYFCLM RTLLTTREIN NVLVSKPVEL
     HVDIVKRILL ASLDIRLHEV SRPSGDLSTG ILLHHLIQVL NCMMQRDQNG WNLLHESSPI
     MLPLLLRTVC ALKQVTIHRT FYVNESVKDL SMLLMRIALK RPILVLKEAT RRIGAHPQEL
     RIQAYLLSII NDIIYPLLKK EEDFLIQIEK DALQEDYLQG RMLGNPYRSS DAGMGPLMRD
     IKNKICRDCE LVALLDDDTG MELLVNQQIV ALDLPVNDVY EKLWRSDHHG QAMVIVYRMR
     GLLGDATEPF IKTLANTNVK EKVDDSQLRL ASALGSPIRA FATILPILDN IELTGGGIIL
     LRELHRLLTH CMKVEGNREQ LNEYGGIRRF LHVFEVAYRS GIKEKSIEET IALQYLELSR
     ILLVDVLATD RIEKSIGGAS FEQTSWLLEL SMGSDEELSA SLLEAVTSIA PNLCLGNAES
     MDALVETFRP CCHWDEIGLF SFCFSDKVLM KLSNISNKAS VIDNDRKIRD RVVQKVEILC
     KITSAIHDSA SGRILKKKMM DAGLITDACR YLAENHPPIF NVSVMGPEWK YFLSKPSLKY
     VLKLMAGMAR SHKPSQEAIA ENSLPILHRL EQISSAEHIG TLAENVMEEL KKNDQVAVQI
     EKVRQETKIK KRQLAMAMRQ KQLSKMGMEI GKKGQVKVSA RKLINEPHSL ESVSDISICC
     ICREAMDASA KIMMVYAFAS RLNLKENKVI NGRNYSFTTV SQMNLVHLDC HSVAVRMAGS
     RSEWASAALH NANTKCNVIM PIWSKQVKDS DMEHSFQRLS TDLEVAVDCD TINLDSLTLD
     IAELLDRFVK FRSFSALSHG GGRESNMQYM AILILLVQYL KKVSPSSEPA EAHSFTHEIS
     ISLVMDTAEQ WNDKRLDLLK SLQGSKKSWK DARHELLVWV AVDYYHNKIL QCRTGDRTQH
     MRENIIKILE NCSKFVSYFD SELSQCRSYG ELMKAVGKR
//